CAS No.108-43-0,3-Chlorophenol Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	108-43-0
Name:	3-Chlorophenol
Article Data:	192

Formula:	C₆H₅ClO
Molecular Weight:	128.558
Synonyms:	Phenol,m-chloro- (7CI,8CI);3-Hydroxychlorobenzene;NSC 59700;m-Chlorophenic acid;m-Chlorophenol;
EINECS:	203-582-6
Density:	1.218 g/cm³
Melting Point:	31-34 °C(lit.)
Boiling Point:	214 °C at 760 mmHg
Flash Point:	76.9 °C
Solubility:	27.7 g/L (20 °C) in water
Appearance:	White to light yellow crystal
Hazard Symbols:	Xn,N
Risk Codes:	20/21/22-51/53
Safety:	28-61-28A
Transport Information:	UN 2020 6.1/PG 3
PSA:	20.23000
LogP:	2.04560

Synthetic route

: 123195-73-3
1-tert-butoxy-3-chlorobenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With sodium iodide; cerium(III) chloride In acetonitrile at 40℃; for 3.5h;	100%

: 24318-02-3
1-(benzyloxy)-3-chlorobenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.0833333h; Microwave irradiation; Inert atmosphere;	99%
With triethylsilane; triethylamine; palladium diacetate In dichloromethane at 23℃; for 12h; Hydrogenolysis;

: 576-24-9
2,3-dichlorophenol

A: 108-43-0
3-monochlorophenol

B: 108-95-2
phenol

Conditions

Conditions	Yield
With 9,10-dihydroanthracene; water at 356.85℃; for 3h; Kinetics;	A 99% B 0.3%

: 108-37-2
1-bromo-3-chlorobenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos In 1,4-dioxane; water at 100℃; for 1h;	99%
Multi-step reaction with 2 steps 1: copper dichloride; potassium carbonate / 20 h / 130 °C / Inert atmosphere; Schlenk technique 2: potassium hydroxide / dimethyl sulfoxide / 3 h / 100 °C / Schlenk technique View Scheme
Multi-step reaction with 2 steps 1: fac-tris(2-phenylpyridinato-N,C2')iridium(III); tributyl-amine; water / acetonitrile / 36 h / 25 °C / Schlenk technique; Inert atmosphere; Sealed tube; Irradiation 2: air / 16 h / 25 °C / Inert atmosphere View Scheme
With copper(l) iodide; C20H20N4O4; caesium carbonate; Benzaldoxime In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere; Glovebox;

: 63503-60-6
3-chlorophenylboronic acid

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With water In tetrahydrofuran at 100℃; for 12h;	99%
With copper(I) oxide; potassium hydroxide In water at 20℃; for 24h; Green chemistry;	98%
With copper(II) ferrite; water; sodium hydroxide at 40℃; for 24h; Green chemistry;	96%

: 2655-83-6
1-chloro-3-ethoxybenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.666667h; Microwave irradiation; Inert atmosphere;	99%

: 6161-83-7
2-(3-chlorophenoxy)ethanol

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;	99%

: 625-99-0
3-iodochlorobenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;	98%
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 24h; Schlenk technique; Inert atmosphere; chemoselective reaction;	95%
With copper(I) oxide; 2-(N,N-dimethylamino)ethanol; water; potassium hydroxide In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;	91%

: 63503-60-6
3-chlorophenylboronic acid

: 7722-84-1
dihydrogen peroxide

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;	97%

: 1005-41-0
1-chloro-3-vinyloxybenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;	92%
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	92%

Raw Materials

108-42-9

2655-83-6

541-73-1

3046-27-3

372-20-3

123195-73-3

587-04-2

590-29-4

Downstream Products

18113-14-9

580-51-8

171569-42-9

519-73-3

150-19-6

35370-95-7

43141-69-1

5106-98-9

Total:90 Page 1 of 3 1 2 3 Next>>

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Chemistry

IUPAC:3-chlorophenol
CAS:108-43-0
The Molecular formula of 3-Chlorophenol(108-43-0):C₆H₅ClO
The Molecular Weight of 3-Chlorophenol(108-43-0):128.56
Synonyms:3-chloro-1-hydroxybenzene;3-chloro-pheno;3-Hydroxychlorobenzene;m-chlorophenicacid;m-chloro-pheno;meta-Chlorophenol;Phenol, m-chloro-;Phenol
EINECS:203-582-6
Density:1.218 g/cm³
Melting Point:33-35^oC
Boiling Point:214^oC
Flash Point:97^oC
Refractive index:n20/D 1.563(lit.)
Water Solubility:27.7 g/L (20^oC)
Storage temp.:2-8^oC
Stability:Stable.Combustible.Incompatible with acid chlorides,oxidizing agents,acid anhydrides.Discolours in air.
Vapour Pressure:0.109 mmHg at 25^oC
Appearance:white crystalline solid with an unpleasant smell
Product Categories:Organics;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Chlorine Compounds;Phenols;Alpha sort;C;CAlphabetic;CH;Pesticides&Metabolites;Organic Building Blocks;Oxygen Compounds
Mol File:108-43-0.mol

Uses

3-Chlorophenol(108-43-0) is widely used in the pharmaceutical, dyes and organic synthesis industry.It is also used as a disinfectant.It is an important intermediate in the synthesis of pesticides such as triadimefon,propaphos,phosazetim.

Toxicity Data With Reference

1.	mmo-sat 10 µg/plate	TECSDY Toxicological and Environmental Chemistry. 14 (1987),143.
2.	orl-rat LD50:570 mg/kg	FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 2 (1943),76.
3.	ipr-rat LD50:355 mg/kg	BJPCAL British Journal of Pharmacology and Chemotherapy. 13 (1958),20.
4.	scu-rat LD50:1390 mg/kg	FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 2 (1943),76.
5.	orl-mus LD50:521 mg/kg	TOLED5 Toxicology Letters. 29 (1985),39.

Consensus Reports

Reported in EPA TSCA Inventory. Chlorophenol compounds are on the Community Right-To-Know List.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Flammable or combustible liquid. When heated to decomposition it emits toxic fumes of Cl⁻. See also CHLOROPHENOLS.

Safty informations about 3-Chlorophenol(108-43-0):
Hazard Codes:Xn,N
Risk Statements:20/21/22-51/53
20/21/22(Harmful by inhalation, in contact with skin and if swallowed)
51/53(Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment)
Safety Statements:28-61
28( After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer))
61(Avoid release to the environment. Refer to special instructions safety data sheet)
RIDADR:UN 2020 6.1/PG 3
WGK Germany:2
RTECS:SK2450000
F:9
HazardClass:6.1
HS Code:29081000

Specification

Handling and Storage:
Storage:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Handling:Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.