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CAS No.: | 127-56-0 |
---|---|
Name: | Sulfacetamide sodium |
Molecular Structure: | |
Formula: | C8H9N2NaO3S |
Molecular Weight: | 236.227 |
Synonyms: | Sulfacetamide sodium;N-Acetylsulfanilamide Sodium Salt Hydrate;N-Acetyl-4-aminobenzenesulfonamide Sodium Salt Hydrate;SulfacetaMide SodiuM Salt Hydrate;sodium,acetyl-(4-aminophenyl)sulfonylazanide; |
EINECS: | 204-848-4 |
Melting Point: | 257 °C |
Boiling Point: | 450.8 °C at 760 mmHg |
Flash Point: | 226.4 °C |
Solubility: | Soluble in water |
Appearance: | White crystalline powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
Transport Information: | UN 3249 |
PSA: | 88.85000 |
LogP: | 1.93230 |
cetylpyridinium chloride
sodium 4-aminobenzenesulfonylacetamide
hexadecylpyridinium sulfacetamide
Conditions | Yield |
---|---|
In water for 0.5h; Heating / reflux; | 99.22% |
4-(4-fluorophenyl)-4-oxo-2-hydroxy-2-butenoic acid methyl ester
sodium 4-aminobenzenesulfonylacetamide
2-hydroxy-4-oxo-4-(4-fluorophenyl)-2-butenoic acid N-(4-(acetylaminosulfonyl)phenyl)amide
Conditions | Yield |
---|---|
With acetic acid Reflux; | 95% |
chloroformic acid ethyl ester
sodium 4-aminobenzenesulfonylacetamide
C11H14N2O5S
Conditions | Yield |
---|---|
Ambient temperature; | 91.5% |
sodium 4-aminobenzenesulfonylacetamide
chloroacetic acid ethyl ester
N-Sulfanilyl-N-carbethoxymethylacetamine
Conditions | Yield |
---|---|
In ethanol for 4h; Ambient temperature; | 89.7% |
sodium 4-aminobenzenesulfonylacetamide
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 2h; | 88% |
sodium 4-aminobenzenesulfonylacetamide
N,N-didecyl-N,N-dimethylammonium bromide
didecyldimethylammonium sulfacetamide
Conditions | Yield |
---|---|
In water for 0.5h; | 87.74% |
sodium 4-aminobenzenesulfonylacetamide
methyl chloroacetate
[Acetyl-(4-amino-benzenesulfonyl)-amino]-acetic acid methyl ester
Conditions | Yield |
---|---|
Ambient temperature; | 87.5% |
Conditions | Yield |
---|---|
Ambient temperature; | 85.8% |
sodium 4-aminobenzenesulfonylacetamide
4,6-dichloro-5-methoxypyrimidine
4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 88 - 90℃; for 3h; | 85.3% |
C11H8Cl2O4
sodium 4-aminobenzenesulfonylacetamide
2-hydroxy-4-(2,4-dichlorophenyl)-4-oxo-2-butenoic acid N-(4-acetylaminosulfonylphenyl)amide
Conditions | Yield |
---|---|
With acetic acid Reflux; | 83% |
Reported in EPA TSCA Inventory.
The Sulfacetamide sodium anhydrous, with the CAS registry number 127-56-0,is also known as Sodium sulfacetamide; N-Sulfanilylacetamide monosodium salt; N-(4-Aminophenylsulfonyl)acetamide sodium salt. It belongs to the product categories of Antibiotics for Research and Experimental Use;Biochemistry.Its EINECS number is 204-848-4. This chemical's molecular formula is C8H9N2NaO3S and molecular weight is 236.22. What's more,Its systematic name is Sulfacetamide sodium.It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. The Sulfacetamide sodium is irritating to eyes, respiratory system and skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.When you use it,you should wear suitable protective clothing.
Physical properties about Sulfacetamide sodium anhydrous are:
(1)ACD/LogP: -0.964; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.18; (4)ACD/LogD (pH 7.4): -2.51; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 4.29; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Flash Point: 226.4 °C; (13)Enthalpy of Vaporization: 74.79 kJ/mol ; (14)Boiling Point: 450.8 °C at 760 mmHg; (15)Vapour Pressure: 6.51E-09 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].O=S(=O)([N-]C(=O)C)c1ccc(N)cc1;
(2)Std. InChI:InChI=1S/C8H10N2O3S.Na/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;/h2-5H,9H2,1H3,(H,10,11);/q;+1/p-1;
(3)Std. InChIKey:PQMSFAORUFMASU-UHFFFAOYSA-M.
The toxicity data of Sulfacetamide sodium anhydrous as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | subcutaneous | 6gm/kg (6000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 286, 1959. | |
mouse | LDLo | intravenous | 800mg/kg (800mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 127, 1943. |