Reference

Effect produced by the pattern of applying antineoplastic drugs on their efficacy in treating sarcoma 37

Effect produced by the pattern of applying antineoplastic drugs on their efficacy in treating sarcoma 37. Karaivanova, M. (Dep. Exp. Ther., Cent. Oncol., Sofia, Bulg.). Farmakol. Toksikol. (Moscow), 41(1), 90-2 (Russian) 1978. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The inhibitory effects of sarcolysin [1465-26-5], cyclophosphamide [50-18-0], and alexan [147-94-4] on sarcoma 37 growth in mice depended on their application schedules. Sarcolysin inhibited tumor growth 93.1% when given at 6 mg/kg/day for 5 days beginning on the 4th day after tumor inoculation; at 3 mg/kg/day for 10 days beginning on the 4th day after inoculation tumor growth was inhibited by only 63.2%. Cyclophosphamide given once at 200 mg/kg 5 days after tumor inoculation or at 100 mg/kg at 5 and 8 days after tumor inoculation inhibited tumor growth 81.2% and no animals died. Alexan inhibited tumor growth 75-79% when given at 70 mg/kg/day for 5 days or at 35 mg/kg/day for 10 days beginning 5 days after tumor inoculation.

Protection of the gastrointestinal tract of mice from the toxic effect of cytosine arabinoside

Protection of the gastrointestinal tract of mice from the toxic effect of cytosine arabinoside. Bukhman, V. M.; Vyshinskaya, G. Ya.; Belyanchikova, N. I.; Svet-Moldavskii, G. Ya. (Cent. Oncol. Res., Moscow, USSR). Vopr. Onkol., 23(7), 44-8 (Russian) 1977. CODEN: VOONAW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 2-Deoxycytidine-HCl (I) [3992-42-5] administered orally to mice during i.p. cytosine arabinoside (II) [147-94-4] therapy (i.p. 3 times daily for 5 days) decreased the lethal action of II and protected the mice against all the toxic effects of II (wt. loss, diarrhea, leukopenia, bone marrow damage). I injected in a form adsorbed on activated carbon decreased the intestinal effect of II but did not prevent damage to the hemopoietic system.