Detail of > 21187-98-4
- CAS Number:
- 21187-98-4
- Name:
Gliclazide
- Formula:
- C15H21N3O3S
- Molecular Structure:
- Synonyms:
- Urea,1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)- (8CI);Cyclopenta[c]pyrrole, benzenesulfonamide deriv.;1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea;Diabezidum;Diabyl;Diamicron;Diaprel;Glimicron;Glinormax;Glyzide;N-(4-Methylbenzenesulfonyl)-N'-[3-azabicyclo(3,3,0)oct-3-yl]urea;S1702;S 852;SE 1702;Benzenesulfonamide,N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-;
- Molecular Weight:
- 323.41
- EINECS:
- 244-260-5
- Density:
- 1.35 g/cm3
- Melting Point:
- 163-169 °C(lit.)
- Solubility:
- soluble in methylene chloride
- Appearance:
- white cyrstalline solid
- Hazard Symbols:
Xn,
Xi- Risk Codes:
- 21-36/38-46-62-63
- Safety:
- 25-26-36/37-53Details
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Reference
- Preventive effects of gliclazide on cholesterol-induced atheromatous lesions in the rabbit
- Preventive effects of gliclazide on cholesterol-induced atheromatous lesions in the rabbit. Marquie, Georges (Inst. Biol., Univ. Sci. Technol. Alger, Algers, Algeria). C. R. Hebd. Seances Acad. Sci., Ser. D, 285(2), 197-200 (French) 1977. CODEN: CHDDAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In rabbits on a high cholesterol diet, gliclazide [21187-98-4] (10 mg/kg/day) prevented the formation of arterial plaques. Blood sugar levels and plasma lipid ratios were not affected, except for a decrease in cholesterol levels. Also, aortic lipid levels were markely decreased.
- Effect of gliclazide on irradiation-induced experimental atheromatosis
- Effect of gliclazide on irradiation-induced experimental atheromatosis. Smit Sibinga, C. T.; Wieringa, R. A. (Dep. Intern. Med., Univ. Groningen, Groningen, Neth.). Microcirc., [Proc. World Congr.], 1st, Meeting Date 1975, Volume 1, 224-6. Edited by: Grayson, John; Zingg, Walter. Plenum: New York, N. Y. (English) 1976. CODEN: 35LGAF. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) Gliclazide (I) [21187-98-4] (15 or 25 mg/kg/day for 4 weeks, orally) prevented signs of irradn.-induced atheromatosis in the carotid artery of rabbits having high serum cholesterol.
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