CAS No.3184-13-2,L(+)-Ornithine hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	3184-13-2
Name:	L(+)-Ornithine hydrochloride
Article Data:	6

Formula:	C₅H₁₃ClN₂O₂
Molecular Weight:	168.623
Synonyms:	L-Ornithine,monohydrochloride (9CI);Ornithine, monohydrochloride, L- (8CI);L-Ornithine hydrochloride;Ornithine hydrochloride;Ornithine monohydrochloride;L-Ornithine HCL;H-Orn-OH·HCl;L-Ornithine,hydrochloride (1:1);
EINECS:	221-678-6
Density:	1.57 g/cm³
Melting Point:	245 °C
Boiling Point:	308.7oC at 760 mmHg
Flash Point:	140.5oC
Solubility:	H₂O: 100 mg/mL
Appearance:	white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	24/25-37/39-26
PSA:	89.34000
LogP:	1.33980

Synthetic route

: 1119-34-2
L-arginine hydrochloride

A: 3184-13-2
L-ornithine hydrochloride

B: 57-13-6
urea

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; phosphoric acid; water at 25 - 37.1℃; Thermodynamic data; ΔH; arginase (EC 3.5.3.1); var. pH and ionic strength;

: 26302-89-6
L-ornithine tert-butyl ester

: 3184-13-2
L-ornithine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Heating;	2.7 mmol

: 271601-28-6
1,1-dimethylethyl 4-cyano-(2S)-[(diphenylmethylene)amino]butanoate

: 3184-13-2
L-ornithine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 96 percent / aq. citric acid / tetrahydrofuran / 3 h 2: H2 / platinum oxide / acetic acid / 16 h 3: 2.7 mmol / aq. HCl / Heating View Scheme

: 824956-17-4
tert-butyl 2-amino-4-cyanobutanoate

: 3184-13-2
L-ornithine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / platinum oxide / acetic acid / 16 h 2: 2.7 mmol / aq. HCl / Heating View Scheme

: 64-17-5
ethanol

: 3184-13-2
L-ornithine hydrochloride

: 94231-37-5
L-ornithine, ethyl ester, hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃; Reflux;	100%

: 103-82-2
phenylacetic acid

: 3184-13-2
L-ornithine hydrochloride

: 952154-79-9
L-ornithine phenylacetate

Conditions

Conditions	Yield
Stage #1: L-ornithine hydrochloride With calcium hydroxide In water for 0.5h; Stage #2: phenylacetic acid In water Product distribution / selectivity;	100%
Stage #1: L-ornithine hydrochloride With acetic acid In water at 25 - 40℃; for 72h; Stage #2: phenylacetic acid In water; isopropyl alcohol

: 24424-99-5
di-tert-butyl dicarbonate

: 3184-13-2
L-ornithine hydrochloride

: 1154761-18-8
N,N-di-boc-ornithine

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water for 12h;	99%

: 3184-13-2
L-ornithine hydrochloride

: 42538-31-8
(3S)-3-aminopiperidin-2-one hydrochloride

Conditions

Conditions	Yield
Stage #1: L-ornithine hydrochloride With chloro-trimethyl-silane In methanol at 20℃; under 760.051 Torr; for 12h; Stage #2: With sodium ethanolate In methanol; ethanol at 0 - 20℃; under 760.051 Torr; for 0.583333h; enantioselective reaction;	97%
Multi-step reaction with 2 steps 1: SOCl2 / -15 - 20 °C 2: 2.25 mg / Et3N / acetonitrile / 4 h / 20 °C View Scheme
Multi-step reaction with 2 steps 2: 1.) sodium methylate, 2.) hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: thionyl chloride / 3 h / 0 - 55 °C / Large scale 2: sodium carbonate / water / 12 h / 5 - 20 °C / Large scale View Scheme

: 3184-13-2
L-ornithine hydrochloride

: L-ornithine methyl ester hydrochloride

Conditions

Conditions	Yield
In methanol	97%
In methanol	97%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 3184-13-2
L-ornithine hydrochloride

: 147071-84-9
(S)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminopentanoic acid

Conditions

Conditions	Yield
Stage #1: L-ornithine hydrochloride With copper diacetate; sodium carbonate for 0.75h; Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In 1,4-dioxane; water for 0.75h; Further stages.;	96%

Raw Materials

Downstream Products

841-67-8

372-75-8

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

1. Introduction of L(+)-Ornithine hydrochloride

L(+)-Ornithine hydrochloride (3184-13-2), with the IUPAC name of 2,5-diaminopentanoic acid hydrochloride, is one kind of white crystalline powder. And it belongs to the product categories which include Amino Acid Derivatives; Ornithine [Org]; Amino Acids and Derivatives; alpha-Amino Acids; Amino Acids; Biochemistry; non-Proteinorganic Amino Acids; L-Amino Acids; Amino Hydrochloride. Besides, it is , which should be stored in closed, cool and dry place.

2. Chemical properties of L(+)-Ornithine hydrochloride

The other characteristics of L(+)-Ornithine hydrochloride can be summarized as: (1)EINECS: 221-678-6; (2)ACD/LogP: -0.96; (3)# of Rule of 5 Violations: 1; (4)ACD/LogD (pH 5.5): -4.46; (5)ACD/LogD (pH 7.4): -4.36; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 4; (11)#H bond donors: 5; (12)#Freely Rotating Bonds: 6; (13)Polar Surface Area: 32.78 Å²; (14)Density: 1.57 g/cm³; (15)Flash Point: 140.5 °C; (16)Melting point: 245 °C; (17)alpha: 24 °(c=4, 6N HCl); (18)Solubility: H₂O: 100 mg/mL; (19)Enthalpy of Vaporization: 60.42 kJ/mol; (20)Boiling Point: 308.7 °C at 760 mmHg; (21)Vapour Pressure: 0.00015 mmHg at 25 °C.

3. Preparation of L-Ornithine hydrochloride

L(+)-Ornithine hydrochloride can be prepared by the reaction of phthalimido-(3-phthalimido-propyl)-malonic acid diethyl ester with phthalic acid.

This reaction needs cc.HCl, HOAc and H₂O at temperature of 100 °C. The yield is 62 %.

4. Uses of L-Ornithine hydrochloride

L-Ornithine hydrochloride is used as antidote and liver function accelerating agent to treat cirrhosis. It is also used to recover disease and to invigorate health effectively. Additionally, it can be used to produce 3-amino-piperidin-2-one.

This reaction needs Al₂O₃ and toluene by heating for 3 hours. The yield is 79 %.

5. Safety information of L(+)-Ornithine hydrochloride

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-37/39-26
WGK Germany 3
RTECS RM2985000
F 3-10
HS Code 29224995

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable gloves and eye/face protection to avoid contact with skin and eyes.

6. Structure Descriptors of L(+)-Ornithine hydrochloride

People can use the following data to convert to the molecule structure.
(1)SMILES: Cl.O=C(O)C(N)CCCN
(2)InChI: InChI=1/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H
(3)InChIKey: GGTYBZJRPHEQDG-UHFFFAOYAF

7. Toxicity of L(+)-Ornithine hydrochloride

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	10gm/kg (10000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmaceutical Sciences. Vol. 62, Pg. 49, 1973.

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