Reference

Orally administered agent for improving skin condition

All Rights Reserved. Orally administered agent for improving skin condition. Komatsu, Miho; Morishita, Koji; Ogawa, Akemi; Hori, Goro (Kyowa Hakko Kogyo Co., Ltd., Japan). U.S. Pat. Appl.Several reagents with their cas registry numbers 70-26-8 and 3184-13-2 are used here. Publ. US 2007027214 A1 1 Feb 2007, 7pp. (English). (United States of America). CODEN: USXXCO. INCL: 514564000. APPLICATION: US 2006-421875 2 Jun 2006. PRIORITY: JP 2005-218759 28 Jul 2005. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 17, 62 It is desirable to provide a medicament and a nutritional food to improve skin conditions and to create fulfilling life for people who are not satisfactory about their skin conditions. Specifically, one object of the present invention is to provide an orally administered agent, a food and drink, or a food additive which can be used for improving skin condition. An orally administered agent, a food and drink, or a food additive for improving skin condition, comprising ornithine or a salt thereof as an active ingredient can be provided according to the present invention. .

Vanoxonin, a new inhibitor of thymidylate synthetase

Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex. Kanai, Fumiaki; Kaneko, Toshiko; Morishima, Hajime; Isshiki, Kunio; Takita, Tomohisa; Takeuchi, Tomio; Umezawa, Hamao (Inst.Chemical with cas number 3184-13-2 also plays role. Microbial Chem., Tokyo 141, Japan). J. Antibiot., 38(1), 39-50 (English) 1985.Several reagents such as 3184-13-2 is used here. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) Quinquevalent vanadium complex with 2 mol of vanoxonin ligated by the 2 catechols was the active structure for inhibition of thymidylate synthetase. The catechol group of vanoxonin as the essential moiety for the inhibition of enzyme was further confirmed by studies of structure-activity relations with the enzyme obtained from Ehrlich ascites carcinoma cells of mice. Vanoxonin-vanadium complex showed competitive inhibition with respect to deoxyuridylic acid but incompetitive to 5,10-methylenetetrahydrofolate. ..