Detail of > 366-70-1
- MSDS Download
- CAS Number:
- 366-70-1
- Name:
Procarbazine hydrochloride
- Formula:
- C12H19N3O.HCl
- Molecular Structure:
- Synonyms:
- Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride (9CI);p-Toluamide, N-isopropyl-a-(2-methylhydrazino)-, monohydrochloride (8CI);1-Methyl-2-[p-(isopropylcarbamoyl)benzyl]hydrazine hydrochloride;2-[p-(Isopropylcarbamoyl)benzyl]-1-methylhydrazine hydrochloride;IBZ;Ibenzmethyzin hydrochloride;Ibenzmethyzine hydrochloride;MBH;MIHhydrochloride;Matulane;N-Isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride;N-Isopropyl-a-(2-methylhydrazino)-p-toluamide hydrochloride;NCI-C 01810;NSC 77213;Nathulane;Natulan;Natulan hydrochloride;Natulanar;PCB hydrochloride;Ro 4 6467/1;Ro 4-6467;Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1);
- Molecular Weight:
- 257.80
- EINECS:
- 206-678-6
- Melting Point:
- 223 °C
- Boiling Point:
- 384.6 °C at 760 mmHg
- Flash Point:
- 148.9 °C
- Solubility:
- >=10 g/100 mL at 21.5 °C
- Appearance:
- white to pale yellow crystalline powder
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Reference
- Tumoral drugs as possible blastogenic agents
- Tumoral drugs as possible blastogenic agents. The problem of anti-blastic medication. Llombart, Antonio (Dep. Exp. Cancerol., Fac. Med.Some commonly used reagents like 51-21-8 and 52-24-4 are used in this experiment., Valencia, Spain). Oesterr. Z. Onkol., 3(3), 72-6 (English) 1976. CODEN: OZOKAN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Carcinogenic activity of drugs was studied by injecting into pregnant rats at the 20-21st day of gestation with doses twice that used in human therapeutics, and the drugs and the percentage of tumor formation were Oncotiotepa [52-24-4] 0, daunoblastine [23541-50-6] 3.3, vinblastine (I) [865-21-4] 9, bleomycine [11056-06-7] 12.8, 5-fluorouracil [51-21-8] 12.87, Lyovac [51109-87-6] 16.6, Genoxal [50-18-0] 17.14, and Natulan [366-70-1] 37.42%. The benign form of tumor predominated in all the tumors produced. The tumors were formed in the kidney, liver, mammary gland, nervous system, and skin. .
- Procarbazine hydrochloride
- Procarbazine hydrochloride. Rucki, Richard J. (Hoffmann-LaRoche, Inc., Nutley, N. J., USA). Anal. Profiles Drug Subst., 5, 403-27 (English) 1976. CODEN: APDSB7. DOCUMENT TYPE: Journal; General Review CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 25, 64 A review with 46 refs. of procarbazine-HCl (I) [366-70-1], including its phys. properties, synthesis, stability, metabolites, toxicity, and methods of anal.
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