Procarbazine hydrochloride (366-70-1),Procarbazine hydrochloride (366-70-1) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Procarbazine hydrochloride
CAS No.:
366-70-1
Molecular Structure:
Formula:
C₁₂H₁₉N₃O^.HCl
Molecular Weight:
257.80
Synonyms:
Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride (9CI);p-Toluamide, N-isopropyl-a-(2-methylhydrazino)-, monohydrochloride (8CI);1-Methyl-2-[p-(isopropylcarbamoyl)benzyl]hydrazine hydrochloride;2-[p-(Isopropylcarbamoyl)benzyl]-1-methylhydrazine hydrochloride;IBZ;Ibenzmethyzin hydrochloride;Ibenzmethyzine hydrochloride;MBH;MIHhydrochloride;Matulane;N-Isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride;N-Isopropyl-a-(2-methylhydrazino)-p-toluamide hydrochloride;NCI-C 01810;NSC 77213;Nathulane;Natulan;Natulan hydrochloride;Natulanar;PCB hydrochloride;Ro 4 6467/1;Ro 4-6467;Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1);
EINECS:
206-678-6
Melting Point:
223 °C
Boiling Point:
384.6 °C at 760 mmHg
Flash Point:
148.9 °C
Solubility:
>=10 g/100 mL at 21.5 °C
Appearance:
white to pale yellow crystalline powder

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Chemistry

The Molecular formula of Procarbazine hydrochloride (CAS NO.366-70-1): C₁₂H₂₀ClN₃O
The Molecular Weight of Procarbazine hydrochloride (CAS NO.366-70-1): 257.76
The Molecular Structure of Procarbazine hydrochloride (CAS NO.366-70-1):

Melting point: 223^°C
Boiling point: 384.6 ^°C at 760 mmHg
Flash point: 148.9 ^°C
Solubility in water: >=10 g/100 mL at 21.5 ^°C
Air & Water Reactions: In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen.
Enthalpy of Vaporization: 63.33 kJ/mol
Vapour Pressure: 4.05E-06 mmHg at 25^°C
Appearance: white to pale yellow crystalline powder with a slight odor. Acid to litmus.
IUPAC Name: 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide hydrochloride

Toxicity Data With Reference

1.	dnd-rat-ipr 25 mg/kg	ENMUDM Environmental Mutagenesis. 7 (1985),563.
2.	hma-mus/esc 100 mg/kg	MUREAV Mutation Research. 164 (1986),19.
3.	ivn-rat TDLo:125 mg/kg (22D preg):ETA,REP	ARZNAD Arzneimittel-Forschung. Drug Research. 22 (1972),905.
4.	orl-rat LD50:570 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 6 (1972),355.
5.	scu-rat LD50:490 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),720.
6.	ivn-rat LD50:350 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1467.
7.	orl-rat LD50:785 mg/kg	EVSRBT Environmental Science Research. 24 (1981),977.
8.	orl-mus LD50:560 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 4 (1973),467.
9.	ipr-mus LD50:699 mg/kg	ARTODN Archives of Toxicology. 41 (1979),287.
10.	scu-mus LD50:710 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 4 (1973),467.

Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 327.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 311.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 311.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (ipr); Clear Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-19 ,1979. ; (ipr); Clear Evidence: mouse, rat RRCRBU Recent Results in Cancer Research. 52 (1975),1. . EPA Genetic Toxicology Program.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and HCl. Used as a chemotherapeutic agent.

Specification

Procarbazine hydrochloride (CAS NO.366-70-1) can also be called as N-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride ; Procarbazine hcl ; Procarbazine hydrochloride ; Chlorhydratede1-methyl2p(isopropylcarbamoyl)benzyl-hydrazine ; 1-(P-isopropylcarbamoylbenzyl)-2-methylhydrazinehydrochloride ; 1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazinehydrochloride ; 1-Methyl-2-p-(isopropylcarbamyol)benzohydrazinehydrochloride ; 2-(P-(isopropylcarbamoyl)benzyl)-1-methylhydrazinehydrochloride .