Reference

A concentrated mixture of amino acids and dipeptides for total parenteral nutrition

A concentrated mixture of amino acids and dipeptides for total parenteral nutrition. Vazquez, J. A.; Paleos, G. A.; Lochs, H.; Langer, K.; Brandl, M.; Adibi, S. A. (Sch. Med., Univ. Pittsburgh, Pittsburgh, PA, USA). Infusionsther. Klin. Ernaehr. - Forsch. Prax., 13(4), 193-7 (English) 1986. CODEN: IKEFAP. ISSN: 0378-0791. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) The utility of a 20% mixt. of amino acids and dipeptides as the N source for total parenteral nutrition was studied in baboons. The mixt., besides contg. all 8 essential amino acids and a no. of nonessential amino acids (glutamate [56-86-0], aspartate [56-84-8], arginine [74-79-3], histidine [71-00-1], serine [56-45-1], ornithine [70-26-8], and alanine [56-41-7]), contained 6 dipeptides (Gly-Ile [19461-38-2], Gly-Leu [869-19-2], Gly-Val [1963-21-9], Gly-Tyr [658-79-7], Gly-Gln [13115-71-4], and Ala-Gln [39537-23-0]) and acetylcysteine. A week of total parenteral nutrition was preceded by 1 wk of oral feeding. The caloric intake and compn. during the 2 periods was identical except for the N source, which was intact protein during the oral period, and the mixt. of amino acids and dipeptides during the parenteral period. There was no significant difference between gain in body wt. or N balance during the 2 periods. There were selective increases in plasma and muscle concns. of amino acids during the parenteral period, which appeared to reflect the amino acid enrichment of the N source. The efficient utilization of dipeptides was evidenced by their low concns. in plasma and urine. The urinary excretion of dipeptides was about 1% of the amt. infused. This efficiency of dipeptide utilization persisted even when the infusion rate of the amino acid and dipeptide mixt. was increased 7-fold. There was no alteration in liver, kidney, and immune function during the parenteral period. The mixt. of amino acids and dipeptides was effective as the N source for parenteral nutrition.

Complete parenteral feeding with and without a synthetic dipeptide (L-alanyl-L-glutamine) in rats with experimental catabolism

Complete parenteral feeding with and without a synthetic dipeptide (L-alanyl-L-glutamine) in rats with experimental catabolism. Albers, S.; Abele, R.; Amberger, I.; Mangold, J.; Pfaender, P.; Fuerst, P. (Inst. Biol. Chem. Ernahrungswiss., Univ. Hohenheim, Stuttgart, Fed. Rep. Ger.). Aktuel. Ernaehrungsmed., 9(4), 147-9 (German) 1984. CODEN: AEKPDQ. ISSN: 0341-0501. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Utilization of synthetic L-alanyl-L-glutamine (I) [39537-23-0] dipeptide in parenteral nutrition of rats catabolized by trauma (median laparotomy) and in intact rats was studied using radioisotope studies. In the intact rats, >50% of the label (14CO2) was accumulated in the muscles followed (in descending order) by the liver, blood plasma, and kidneys; excretion of the dipeptide label with the urine was <1%. Traumatized rats without parenteral I showed marked decrease in the accumulation of the label by the muscles (8.86 vs. 15-76 mmol/g dry matter), liver (11.84 vs. 16.86 mmol/g dry matter), and blood plasma (379.9 vs. 50.3 mmol/L) compared to that in the intact controls. Parenteral feeding of I to exptl. catabolized rats increased incorporation of the label into the muscle, liver, and blood plasma to 14.82 and 13.75 mmol/g dry matter and 425 mmol/L, resp.