Reference

Inactivation of the infectivity of

Inactivation of the infectivity of .Some chemicals with cas registry numbers like 84-80-0 and 481-85-6 are also used.vphi.X174 DNA with some quinone derivatives. Komano, Tohru; Morita, Junji (Dep. Agric. Chem., Kyoto Univ., Kyoto, Japan). Nucleic Acids Res., Spec. Publ., 2(Symp. Nucleic Acids Chem., 4th, 1976), 131-3 (English) 1976. CODEN: NARPD6. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 6 Menadione (I) [58-27-5] inactivated the infectivity of .vphi.X174 DNA, however reduced I [481-85-6] more effectively inactivated .vphi.X174 DNA. Reduced phylloquinone [572-96-3] and ubiquinone-6 [1065-31-2] also inactivated .vphi.X174 DNA, but phylloquinone [84-80-0] did not affect .vphi.X174 DNA at <2 .times. 10-4M. Inactivation of .vphi.X174 DNA by reduced I was caused partially by DNA strand breakage. But DNA strand breakage by I was not obsd. .

Studies on thymidine-triphosphate synthesis in malignant tumors

Studies on thymidine-triphosphate synthesis in malignant tumors. II. Effect of hyperthermia, vitamin K and cytotoxic agents. Kummer, D.; Kraml, F. (Chir. Klin., Univ. 127-07-1 and 59-05-2 are cas registry numbers. These chemicals are also mentioned in this article. Tuebingen, Tuebingen, Ger.). Z. Krebsforsch. Klin. Onkol., 88(2), 145-56 (German) 1977. CODEN: ZKKOBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Hyperthermia(41.degree.) inhibited DNA synthesis and ribonucleotide reductase [9040-57-7] activity in Ehrlich ascites carcinoma cells, and decreased the cell dTTP [365-08-2] activity. Menadione (I) [58-27-5] (10-5-10-4M) inhibited DNA synthesis and decreased the cell dTTP and dATP [1927-31-7] levels; these effects were reversed by addn. of glucose [50-99-7]. The effects of hyperthermia and I were additive. I did not affect ribonucleotide reductase and thymidine kinase. Among several cytotoxic drugs tested, cytosine arabinoside [147-94-4], deoxycytidine [951-77-9], hydroxyurea [127-07-1], Trenimon [68-76-8], daunomycin [20830-81-3], and adriamycin [23214-92-8] all inhibited ribonucleotide reductase, the last 2 only in cell-free systems. These drugs variously increased or decreased cellular dATP and dTTP levels. The results are discussed in relation to the mechanisms of action of these agents. .