Reference

Effect of agonists and antagonists of cholinergic M and N receptors on the GABA level and GAD activity in the rat cerebellum

Effect of agonists and antagonists of cholinergic M and N receptors on the GABA level and GAD activity in the rat cerebellum. Sieklucka-Dziuba, Maria; Kleinrok, Zdzislaw (Inst. Patol. Klin., Akad. Med., Lublin, Pol.). Ann. Univ. Mariae Curie-Sklodowska, Sect. D, Volume Date 1982, 37, 293-300 (Polish) 1984. CODEN: AUMKAS. ISSN: 0066-2240. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The effects of cholinergic agents atropine sulfate [55-48-1], pilocarpine [92-13-7], physostigmine salicylate [57-64-7], lobeline [90-69-7], mecamylamine [60-40-2], d-tubocurarine chloride [57-94-3], phentolamine [50-60-2], nicotine [54-11-5], and propranolol [525-66-6] on GABA [56-12-2] levels and glutamate decarboxylase [9024-58-2] activity in the rat cerebellum were investigated. Stimulation of M-cholinergic receptors decreased, while stimulation of N-cholinergic receptors increased GABA levels. The decarboxylase activity was not much affected by the cholinergic agent, indicating that there is no correlation between glutamate decarboxylase activity and the action of the cholinergic agents on GABA levels.

Stability of meperidine hydrochloride, promethazine hydrochloride, and atropine sulfate in plastic syringes

Stability of meperidine hydrochloride, promethazine hydrochloride, and atropine sulfate in plastic syringes. Rhodes, Richard S.; Rhodes, Pamela J.; McCurdy, H. Horton (Sch. Pharm., Univ. Colorado, Denver, CO 80262, USA). Am. J. Hosp. Pharm., 42(1), 112-15 (English) 1985. CODEN: AJHPA9. ISSN: 0002-9289. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The stability of a combination of meperidine-HCl (I) [50-13-5] 50 mg, promethazine-HCl (II-HCl) [58-33-3] 25 mg, atropine sulfate III) [55-48-1] 0.4 mg in plastic syringes at room temp. was studied. The samples were tested for each drug after 0.5, 1, 3, 6, and 24 h in the syringes. Freshly prepd. mixts. of the drugs in glass containers were used as controls, and 3 trials using sep. test mixts. were performed. A gas chromatog. procedure was used; atropine was sepd. from the mixt. and assayed alone for greater accuracy. Drug concns. in the plastic syringes were not significantly different from controls at any of the test times. A mixt. of I, II, and III in dosages commonly administered as a preoperative medication was stable for 24 h in plastic syringes.