Reference

1-(4-Methylsulfonylphenyl)-2-acetamido-3-fluoro-1-propanol derivatives for infection control in fish

1-(4-Methylsulfonylphenyl)-2-acetamido-3-fluoro-1-propanol derivatives for infection control in fish. (Takeda Chemical Industries, Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59112913 A2 29 Jun 1984 Showa, 7 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-16; A61K031-22. APPLICATION: JP 82-223523 20 Dec 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 18 Antibiotic feeds contain I (X = Cl, or F; R = H or glycyl) to control bacterial infections in fish. Thus, D-threo-1-(4-methylsulfonylphenyl)-2-dichloroacetamido-3-fluoro-1-pr opanol [73231-34-2] 1 and lactose 19 parts were mixed, and 800 g of this mixt. was mixed with 10 kg feed contg. vitamins, pulverized fish, soybean, and liver, and thickening agent (guar gum, 5% by wt.). This was mixed with 300 kg sardines, minced and administered to yellowtails (total wt. about 1 ton) for the control of bacterial infections. Antimicrobial activities of I derivs. were shown in yellowtails and eels.

Pharmacokinetics of florfenicol in veal calves

Pharmacokinetics of florfenicol in veal calves. Varma, K. J.; Adams, P. E.; Powers, T. E.; Powers, J. D.; Lamendola, J. F. (Dep. Vet. Physiol. Pharmacol., Coll. Vet. Med., Columbus, OH 43210-1092, USA). J. Vet. Pharmacol. Ther., 9(4), 412-25 (English) 1986. CODEN: JVPTD9. ISSN: 0140-7783. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 17 The pharmacokinetic disposition of SCH 25298 (florfenicol) [73231-34-2] was described in veal calves after administration of a single 22-mg/kg dose, i.v., orally after a 12-h fast and orally 5 min post feeding. Both serum concns. and urinary excretion were studied. After i.v. administration, the median elimination half-life was 171.9 min, whereas the half-life of the distribution phase was 5.9 min. The median body clearance (Cl) and apparent vol. of distribution (Vz) were 2.85 mL/kg/min and 0.7, L/kg, resp. Following oral administration the median bioavailability (f) was 0.88 for calves dosed after a 12-h fast and 0.65 for calves dosed 5 min post feeding. Calves given the oral doses had a complex absorption pattern with delayed absorption. Slightly more than 50% of the administered dose both orally and i.v. was recovered as unchanged florfenicol in the urine by 30 h.