Reference

Effect of phenothiazine, allopurinol, and glucaron on nitrofuran binding in rats

Effect of phenothiazine, allopurinol, and glucaron on nitrofuran binding in rats. Morton, K. C.; Wang, C. Y. (Dep. Chem. Carcinog., Michigan Cancer Found., Detroit, MI 48201, USA). Drug Metab. Dispos., 12(5), 672-3 (English) 1984. CODEN: DMDSAI. ISSN: 0090-9556. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 The effect of phenothiazine [92-84-2], allopurinol [315-30-0], and glucaron [642-83-1] (all administered in the diet) on the in vivo binding of 35S-labeled N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (I) [24554-26-5] (administered by intubation) to macromols. of susceptible and nonsusceptible organs for I carcinogenesis was studied in rats. The percentage of total radioactive dose excreted in the 18-h urine was elevated in phenothiazine-treated rats (36.6 vs. 31.8), but excretion was not significantly different from control in rats treated with allopurinol or glucaron. Macromol. binding of I was detected in both target (urinary bladder) and nontarget (liver and kidney) organs for I carcinogenesis. None of the 3 drugs tested increased the levels of I bound to urinary bladder protein or RNA. However the reaction of I with DNA in the kidney was greatly enhanced by all 3 compds. Thus, although all 3 test compds. did affect I reaction with nucleic acid in nontarget organs, there is at present no evidence that these drugs enhance I bladder carcinogenesis by increasing the extent of alteration of bladder epithelial macromols.

Oxidation of phenothiazine and its N-methyl derivatives by iodoxylbenzene-vanadyl acetylacetonate

Oxidation of phenothiazine and its N-methyl derivatives by iodoxylbenzene-vanadyl acetylacetonate. Pautet, F.; Barret, R.; Daudon, M. (Lab. Chim. Org., Fac. Pharm. Lyon, Lyon F-69373, Fr.Several reagents such as 3153-26-2 is used here.). Pharmazie, 40(3), 202-3 (French) 1985. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 10H-Phenothiazine is oxidized in refluxing C6H6 by PhIO2 with VO(acac)2 catalyst to give the 5-oxide (I; R = H), phenothiazinone II and a bimol. phenothiazinone III. Under similar conditions 10-methyl-10H-phenothiazine gives I (R = H, Me) and II. These oxidns. are models for certain biochem. degrdns. of therapeutic phenothiazines. .