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| CAS No.: | 92-87-5 |
|---|---|
| Name: | Benzidine |
| Article Data: | 256 |
| Molecular Structure: | |
|
|
|
| Formula: | C12H12N2 |
| Molecular Weight: | 184.241 |
| Synonyms: | Benzidine(8CI);4,4'-Bianiline;4,4'-Biphenyldiamine;4,4'-Diamino-1,1'-biphenyl;4,4'-Diaminobiphenyl;4,4'-Diaminodiphenyl;4,4'-Diphenylenediamine;4-(4-Aminophenyl)aniline;4'-Amino-[1,1'-biphenyl]-4-ylamine;C.I. Azoic DiazoComponent 112;Fast Corinth Base B;NSC 146476;p,p'-Bianiline;p,p'-Diaminobiphenyl;p-Diaminodiphenyl; |
| EINECS: | 202-199-1 |
| Density: | 1.156 g/cm3 |
| Melting Point: | 127-128 °C |
| Boiling Point: | 358.7 °C at 760 mmHg |
| Flash Point: | 203.5 °C |
| Solubility: | Sparingly soluble in water. <0.1 g/100 mL at 22 °C |
| Appearance: | off-white solid |
| Hazard Symbols: |
 T, N, F, Xn
|
| Risk Codes: | 45-22-50/53-52/53-39/23/24/25-23/24/25-11-36/37/38-20/21/22 |
| Safety: | 53-45-60-61-36/37-16-7-36-26 |
| Transport Information: | UN 1885 6.1/PG 2 |
| PSA: | 52.04000 |
| LogP: | 3.68040 |
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- 929897-32-51-hexyl-4-methylpridine hexafluorophosphate
- 936239-96-24-methyl-1-octylpyridinium tetrafluoroborate(1-)
| Conditions | Yield |
|---|---|
| With C24H12Cu2F9N4O7; tetrabutylammomium bromide; ammonia; caesium carbonate In water; ethylene glycol at 110 - 140℃; for 16h; | 100% |
| With bis(tri-ortho-tolylphosphine)palladium(0); (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere; | 79% |
| Conditions | Yield |
|---|---|
| With magnesium In water at 100℃; for 2h; Sealed tube; | 96% |
| With tetrabutylammomium bromide; palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide Buchwald-Hartwig Coupling; | 75% |
| With tetrabutylammonium tetrafluoroborate In acetonitrile at 20℃; for 8h; Electrochemical reaction; | 38% |
| Conditions | Yield |
|---|---|
| With hydrazine In methanol at 50℃; | 95% |
| With sodium tetrahydroborate In ethanol at 24.84℃; for 2h; | 95% |
| With hydrazine hydrate In ethanol at 70℃; for 4h; chemoselective reaction; | 93% |
| Conditions | Yield |
|---|---|
| With carbon dioxide; aluminium; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 65℃; under 116262 Torr; for 16h; Ullmann reaction; | 95% |
| With 4-(3'-butyl-1'-imidazolio)-1-butanesulfonic acid hydrogen sulfate; aluminium In carbon dioxide at 45℃; under 116262 Torr; for 16h; Ullmann reaction; Supercritical conditions; | 94% |
| With sulphonic acid functionalized porphyrin meso-substituted triazolium anchored ionic liquid at 20℃; for 16h; Catalytic behavior; Time; Ullmann Condensation; Irradiation; | 91% |
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; potassium acetate; bis(pinacol)diborane In ethanol at 60℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere; | 94.3% |
| With potassium carbonate In N,N-dimethyl-formamide for 0.75h; | 90% |
| With magnesium In water at 100℃; for 3.5h; Sealed tube; | 85% |
| Conditions | Yield |
|---|---|
| With copper(l) iodide; tetra(n-butyl)ammonium hydroxide; ammonia In water at 25℃; for 24h; Inert atmosphere; Sealed tube; chemoselective reaction; | 91% |
- 1221066-38-1
N4,N4'-bis(diphenylmethylene)biphenyl-4,4'-diamine
- 92-87-5
p,p'-diaminobiphenyl
| Conditions | Yield |
|---|---|
| With hydrogenchloride In tetrahydrofuran; water at 20℃; for 2h; | 82% |
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In ethanol at 70℃; for 4h; chemoselective reaction; | A 82% B 7% |
- 89415-43-0
(4-aminophenyl)boronic acid
- 92-87-5
p,p'-diaminobiphenyl
| Conditions | Yield |
|---|---|
| With dipotassium peroxodisulfate; potassium carbonate In water; acetone for 3h; | 80% |
| Conditions | Yield |
|---|---|
| In ethanol; water | A 30% B 70% |
| With hydrogenchloride; lithium chloride In ethanol at 0℃; for 0.5h; Product distribution; kinetic isotope effects; reaction of var. labeled hydrazobenzenes, var. time; | A 91.5 mg B 15.8% |
| With hydrogenchloride; lithium chloride In ethanol at 0℃; for 0.5h; | A 91.5 mg B 15.8% |
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- 9046-10-0Poly[oxy(methyl-1,2-ethanediyl)], α-(2-aminomethylethyl)-ω-(2-aminomethylethoxy)-
- 3077-12-1Ethanol,2,2'-[(4-methylphenyl)imino]bis-
- 6325-91-32H-Benzimidazole-2-thione,1,3-dihydro-5-nitro-
- 54528-00-6Cyclopenta[c]pyrrol-2(1H)-amine,hexahydro-
- 10038-98-9Germanium tetrachloride
- 42933-44-82-Benzofurancarboxylicacid, 5-amino-
- 74483-51-5Benzene,1,2-dichloro-4-methyl-5-(trifluoromethyl)-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
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- 68-19-9Cyanocobalamin
- Total:17 Page 1 of 1 1
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Consensus Reports
Standards and Recommendations
ACGIH TLV: Confirmed Human Carcinogen
DFG MAK: Human Carcinogen
DOT Classification: 6.1; Label: Poison
Analytical Methods
Specification
The Benzidine with CAS registry number of 92-87-5 is also known as [1,1'-Biphenyl]-4,4'-diamine. The IUPAC name is 4-(4-Aminophenyl)aniline. It belongs to product categories of Intermediates of Dyes and Pigments; Azo dye; Amines; Aromatics; Method 8270More...Close...;8000 Series Solidwaste Methods; Analytical Standards; AromaticsChemical Class; AromaticsMethod Specific; BenzidinesEPA; Chemical Class; A-BMethod Specific; Aryl Amines MAK III, Category 1Alphabetic; Alpha Sort; B; BA - BHEnvironmental Standards; Benzidines; Oeko-Tex Standard 100; Volatiles/ Semivolatiles. Its EINECS registry number is 202-199-1. In addition, the formula is C12H12N2 and the molecular weight is 184.24.
Physical properties about Benzidine are: (1)ACD/LogP: 1.56; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.5; (4)ACD/LogD (pH 7.4): 1.56; (5)ACD/BCF (pH 5.5): 7.83; (6)ACD/BCF (pH 7.4): 9.06; (7)ACD/KOC (pH 5.5): 145.68; (8)ACD/KOC (pH 7.4): 168.41; (9)#H bond acceptors: 2; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 6.48Å2; (13)Index of Refraction: 1.667; (14)Molar Refractivity: 59.31 cm3; (15)Molar Volume: 159.2 cm3; (16)Polarizability: 23.51×10-24cm3; (17)Surface Tension: 54.2 dyne/cm; (18)Density: 1.156 g/cm3; (19)Flash Point: 203.5 °C; (20)Enthalpy of Vaporization: 60.43 kJ/mol; (21)Boiling Point: 358.7 °C at 760 mmHg; (22)Vapour Pressure: 2.5E-05 mmHg at 25 °C.
Preparation of Benzidine: it is prepared in a two step process from nitrobenzene. First, the nitrobenzene is converted to 1,2-diphenylhydrazine, usually using iron powder as the reducing agent. Treatment of this hydrazine with mineral acids induces a rearrangement reaction to 4,4'-benzidine. Smaller amounts of other isomers are also formed. The benzidine rearrangement, which proceeds intramolecularly, is a classic mechanistic puzzle in organic chemistry.
Uses of Benzidine: it has been significantly withdrawn from use in most industries because it is so carcinogenic. In the past, benzidine was used to test for blood. An enzyme in blood causes the oxidation of benzidine to a distinctively blue-coloured derivative. The test for cyanide relies on similar reactivity. Such applications have largely been replaced by methods using phenolphthalein/hydrogen peroxide and luminol.
When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. This chemical is very toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment. Besides, it's danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. This chemical even may cause cancer. During using it, wear suitable protective clothing, gloves and eye/face protection. Keep away from sources of ignition and keep container tightly closed. This material and its container must be disposed of as hazardous waste. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. What's more, if you feel unwell seek or accident happens medical advice immediately.
You can still convert the following datas into molecular structure:
1. SMILES: c2c(c1ccc(N)cc1)ccc(N)c2
2. InChI: InChI=1/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2
3. InChIKey: HFACYLZERDEVSX-UHFFFAOYAX
4. Std. InChI: InChI=1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2
5. Std. InChIKey: HFACYLZERDEVSX-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | oral | 200mg/kg (200mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 58, Pg. 167, 1907. | |
| mouse | LD50 | intraperitoneal | 110mg/kg (110mg/kg) | Progress in Mutation Research. Vol. 1, Pg. 682, 1981. | |
| mouse | LD50 | oral | 214mg/kg (214mg/kg) | National Technical Information Service. Vol. PB214-270, | |
| rabbit | LDLo | oral | 200mg/kg (200mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 58, Pg. 167, 1907. | |
| rat | LD50 | oral | 309mg/kg (309mg/kg) | National Technical Information Service. Vol. PB214-270, |