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Conditions | Yield |
---|---|
With pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid In acetonitrile Inert atmosphere; | 100% |
In water at 180℃; under 3750.38 Torr; for 4h; Catalytic behavior; | 100% |
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 9-azabicyclo<3.3.1>nonane-N-oxyl In acetonitrile at 22℃; for 2h; Reagent/catalyst; | 98% |
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; nitromethane; oxygen; 1,10-ethyleneisoalloxazinium chloride at 40℃; for 24h; | A 6 %Spectr. B 90% |
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 9-azabicyclo<3.3.1>nonane-N-oxyl In acetonitrile at 22℃; for 2h; Reagent/catalyst; | A 38% B 87% |
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate In acetonitrile at 22℃; for 2h; Reagent/catalyst; | A 45% B 45% |
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate In acetonitrile at 22℃; for 12h; Temperature; Reagent/catalyst; | A 44% B 34% |
With 0.5C32H30N4O4Pd2(4+)*2CF3O3S(1-); oxygen In acetonitrile at 60℃; under 760.051 Torr; for 26h; Reagent/catalyst; Temperature; |
2-(2-methoxyethoxy)acetic acid
p-dioxanone
Conditions | Yield |
---|---|
With hydrogen bromide In water at 0℃; pH=3; Reflux; | 60% |
With hydrogen bromide at 150℃; |
Conditions | Yield |
---|---|
With chromium(VI) oxide; Salpetersaeuretrimethylsilylester In acetonitrile for 24h; Ambient temperature; | 52% |
With TS-1 (titanium silicate); dihydrogen peroxide | 5% |
With hydrogenchloride; sodium hypochlorite |
Conditions | Yield |
---|---|
at 190℃; |
trans-2,3-dichloro-1,4-dioxane
p-dioxanone
Conditions | Yield |
---|---|
With formic acid at 200℃; |
(2-chloroethoxy)-acetic acid
p-dioxanone
Conditions | Yield |
---|---|
With sodium hydroxide unter vermindertem Druck; |
A
formaldehyd
B
ethylene glycol monoformate
C
ethylene glycol diformate
D
4-cyanonitrosobenzene
E
1,4-dioxane-2-ol
F
p-dioxanone
Conditions | Yield |
---|---|
With dinitrogen monoxide In water Mechanism; Product distribution; Rate constant; Ambient temperature; Irradiation; other ethers; |
diethylene glycol
A
2-methyl-1,3-dioxolane
B
1,4-dioxane
C
1,4-dioxene
D
p-dioxanone
Conditions | Yield |
---|---|
With zeolite NaY; copper at 280℃; further catalysts and conditions; Yield given; | |
With zeolite NaY; copper at 280℃; Product distribution; effect of support on selectivity of dioxene formation; further catalysts and conditions; |
p-dioxanone
Conditions | Yield |
---|---|
Bei der Destillation; |
The p-Dioxan-2-one, with the CAS registry number 3041-16-5, is also known as Acetic acid, (2-hydroxyethoxy)-, gamma-lactone (6CI,7CI). This chemical's molecular formula is C4H6O3 and molecular weight is 102.08864. Its IUPAC name is called 1,4-dioxan-2-one.
Physical properties of p-Dioxan-2-one: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 3.628; (4)ACD/KOC (pH 7.4): 3.628; (5)#H bond acceptors: 3; (6)Index of Refraction: 1.426; (7)Molar Refractivity: 21.788 cm3; (8)Molar Volume: 85.039 cm3; (9)Surface Tension: 34.701 dyne/cm; (10)Density: 1.201 g/cm3; (11)Flash Point: 85.464 °C; (12)Enthalpy of Vaporization: 45.937 kJ/mol; (13)Boiling Point: 222.895 °C at 760 mmHg; (14)Vapour Pressure: 0.099 mmHg at 25°C.
Preparation of p-Dioxan-2-one: this chemical can be prepared by [1,4]dioxane. This reaction will need reagents NaOCl and aq. HCl.
Uses of p-Dioxan-2-one: it can be used to produce 2-(2-hydroxy-ethoxy)-N-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-acetamide. The yield is about 84%.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1COC(=O)CO1
(2)InChI: InChI=1S/C4H6O3/c5-4-3-6-1-2-7-4/h1-3H2
(3)InChIKey: VPVXHAANQNHFSF-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD | intraperitoneal | > 500mg/kg (500mg/kg) | "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 213, 1954. | |
rat | LD50 | intraperitoneal | 790mg/kg (790mg/kg) | Cancer Research. Vol. 38, Pg. 1621, 1978. |