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| CAS No.: | 5308-25-8 |
|---|---|
| Name: | 1-Ethylpiperazine |
| Molecular Structure: | |
|
|
|
| Formula: | C6H14 N2 |
| Molecular Weight: | 114.191 |
| Synonyms: | N-Ethylpiperazin;N-Ethylpiperazine;NSC 60707; |
| EINECS: | 226-166-6 |
| Density: | 0.895 g/cm3 |
| Melting Point: | -60 °C |
| Boiling Point: | 156 °C at 760 mmHg |
| Flash Point: | 53 °C |
| Solubility: | soluble in water |
| Appearance: | clear colorless to yellow liquid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| Transport Information: | UN 1993 3/PG 3 |
| PSA: | 15.27000 |
| LogP: | 0.17820 |
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- 5308-25-8
4-ethylpiperazine
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid at 20℃; for 0.0833333h; | 94% |
| Conditions | Yield |
|---|---|
| A 20% B 55% |
- 21863-75-2
4-ethyl-1-formylpiperazine
- 5308-25-8
4-ethylpiperazine
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
| Conditions | Yield |
|---|---|
| With ethanol |
- 98951-41-8
4-ethyl-piperazine-1-carboxylic acid ethyl ester
- 5308-25-8
4-ethylpiperazine
| Conditions | Yield |
|---|---|
| With hydrogen bromide; acetic acid | |
| With hydrogenchloride |
- 24426-42-4
EtN(CH2CN)2
- 5308-25-8
4-ethylpiperazine
| Conditions | Yield |
|---|---|
| With nickel; platinum; benzene at 44℃; Hydrogenation; |
| Conditions | Yield |
|---|---|
| at 265℃; | |
| at 265℃; |
| Conditions | Yield |
|---|---|
| at 250℃; |
- 5308-25-8
4-ethylpiperazine
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal Hydrogenation; |
| Conditions | Yield |
|---|---|
| at 130℃; |
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Chemistry
IUPAC Name:1-ethylpiperazine
Molecular Formula:C6H14N2
Molecular Weight:114.188760 g/mol
Appearance:clear, colorless liquid
Melting Point:-60 °C
Boiling Point:157 °C(lit.)
Flash Point:110 °F
density:0.899 g/mL at 25 °C(lit.)
refractive index:n20/D 1.469(lit.)
storage temp.:flammables area
Water Solubility:soluble
Sensitive:Air
BRN:102971
EINECS:226-166-6
Synonyms of N-ethyl Piperazine(5308-25-8):
1-ethyl-piperazin;Piperazine, 1-ethyl-;ETHYLPIPERAZINE-N;LABOTEST-BB LTBB000704;1-ETHYLPIPERAZINE;AKOS BBS-00003610;N-ETHYLPIPERAZINE;NEPRZ;1-Ethylpiperazine
Categories of N-ethyl Piperazine(5308-25-8):
Piperidines,Piperidones,Piperazines;Piperaizine;Piperazines;Building Blocks;Heterocyclic Building Blocks
Uses
N-ethyl Piperazine(5308-25-8) is used as an intermediate for veterinary medicine mainly used in the production of ciproflmoxacin ethyl.
N-ethyl Piperazine(5308-25-8) is also used as a raw material for the production of dyes and plant protection agents.
Toxicity Data With Reference
Toxicity Information of N-ethyl Piperazine(5308-25-8):
1.rat LC50 inhalation > 9219mg/m3/4H (9219mg/m3)
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION International Journal of Toxicology. Vol. 16
2.rat LD50 oral 2158mg/kg (2158mg/kg)
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES
International Journal of Toxicology. Vol. 16
Safety Profile
Safety Information of N-ethyl Piperazine(5308-25-8):
Hazard Codes:Xi 
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
RIDADR:UN 1993 3/PG 3
WGK Germany:1
RTECS:TM0815500
F:10-34
HazardClass:3
PackingGroup:III
HS Code:29335995
Specification
First Aid Measures of N-ethyl Piperazine(5308-25-8):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin:Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).