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Cas Database |
| Name |
2-Acetyl-5-bromopyridine |
EINECS | 696-558-3 |
| CAS No. | 214701-49-2 | Density | 1.534 g/cm3 |
| PSA | 29.96000 | LogP | 2.04670 |
| Solubility | N/A | Melting Point |
112 °C |
| Formula | C7H6BrNO | Boiling Point | 257.2 °C at 760 mmHg |
| Molecular Weight | 200.035 | Flash Point | 109.4 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1-(5-Bromopyridin-2-yl)ethanone; |
Article Data | 21 |
2-Acetyl-5-bromopyridine Synthetic route
| Conditions | Yield |
|---|---|
| With n-butyllithium In hexane; toluene at -40 - 20℃; for 2h; Inert atmosphere; | 100% |
| Stage #1: 2,5-dibromopyridine With n-butyllithium In hexane; toluene at -40℃; for 0.666667h; Stage #2: N,N-dimethyl acetamide In hexane; toluene at 20℃; for 1h; Further stages.; | 83% |
| Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene Inert atmosphere; Stage #2: N,N-dimethyl acetamide In toluene Inert atmosphere; | 83% |
- 127-19-5
N,N-dimethyl acetamide
- 223463-13-6
2-iodo-5-bromopyridine
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| Stage #1: 2-iodo-5-bromopyridine With n-butyllithium In hexane; toluene at -40℃; for 1h; Stage #2: N,N-dimethyl acetamide In hexane; toluene at -40 - 20℃; for 1h; | 91% |
- 1211592-38-9
5-bromo-N-methyoxy-N-methylpyridine-2-carboxamide
- 676-58-4
methylmagnesium chloride
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 0 - 20℃; for 1h; | 90% |
- 111770-80-0
3-bromo-6-(trimethylsilylethynyl)pyridine
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| With sulfuric acid; mercury(II) diacetate In water; acetone for 1h; Heating; | 80% |
- 75-16-1
methylmagnesium bromide
- 97483-77-7
2-Cyano-5-bromopyridine
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - -10℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran at -35℃; for 0.166667h; Further stages.; | 65% |
| Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - -10℃; for 3h; Stage #2: With hydrogenchloride; water In tetrahydrofuran at -40 - -35℃; for 0.166667h; | 65% |
| Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - -10℃; for 3h; Stage #2: With hydrogenchloride; water In tetrahydrofuran at -40 - -35℃; for 0.166667h; Stage #3: In tetrahydrofuran; water pH=7; potassium phosphate buffer; | 65% |
- 624-28-2
2,5-dibromopyridine
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 65 percent / NaCN / dimethylformamide / 3 h / Heating 2: tetrahydrofuran / 2 h / -20 °C View Scheme |
- 676-58-4
methylmagnesium chloride
- 97483-77-7
2-Cyano-5-bromopyridine
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| Stage #1: methylmagnesium chloride; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20℃; for 2h; Stage #2: With water; ammonium chloride In tetrahydrofuran | |
| Stage #1: methylmagnesium chloride; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20℃; for 2h; Stage #2: With water; ammonium chloride In tetrahydrofuran |
- 30766-11-1
5-bromoisonicotinic acid
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 18 - 25 °C 2: tetrahydrofuran / 1 h / -78 °C View Scheme | |
| Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C 2: tetrahydrofuran / 1 h / 0 - 20 °C View Scheme |
- 845305-87-5
5-bromo-2-(N-methylaminocarbonyl)pyridine
- 917-54-4
methyllithium
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| In tetrahydrofuran at -78℃; for 1h; |
- 223463-13-6
2-iodo-5-bromopyridine
- 214701-49-2
1-(5-bromopyridin-2-yl)ethanone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice 1.2: 0.5 h / 20 °C / Cooling with ice 2.1: manganese(IV) oxide / dichloromethane / 40 °C View Scheme |
2-Acetyl-5-bromopyridine Chemical Properties
Empirical Formula: C7H6BrNO
Molecular Weight: 200.0326
Nominal Mass: 199 Da
Average Mass: 200.0326 Da
Monoisotopic Mass: 198.963269 Da
Index of Refraction: 1.558
Molar Refractivity: 42.06 cm3
Molar Volume: 130.3 cm3
Surface Tension: 44.6 dyne/cm
Density: 1.534 g/cm3
Flash Point: 109.4 °C
Enthalpy of Vaporization: 49.48 kJ/mol
Boiling Point: 257.2 °C at 760 mmHg
Vapour Pressure: 0.0147 mmHg at 25 °C
Structure of 2-Acetyl-5-bromopyridine (CAS NO.214701-49-2):
Product Category of 2-Acetyl-5-bromopyridine (CAS NO.214701-49-2): API intermediates;Pyridines
2-Acetyl-5-bromopyridine Specification
2-Acetyl-5-bromopyridine , its cas register number is 214701-49-2. It also can be called 1-(5-Brom-2-pyridinyl)ethanon ; 1-(5-Bromo-2-pyridinyl)ethanone ; and 5-Bromo-2-acetylpyridine .
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