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4-Chloro-N-methylpiperidine
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  • Name 4-Chloro-N-methylpiperidine
  • EINECS226-942-4
  • CAS No. 5570-77-4
  • Density1.04 g/cm3
  • PSA3.24000
  • LogP1.25730
  • Solubility1.533g/L at 29℃
  • Melting Point160-165 °C
  • FormulaC6H12ClN
  • Boiling Point165.7 °C at 760 mmHg
  • Molecular Weight133.621
  • Flash Point54 °C
  • Transport InformationN/A
  • AppearanceN/A
  • Safety22-24/25
  • Risk Codes10-34-36/38
  • Molecular Structure
    Molecular Structure of 5570-77-4 (4-Chloro-N-methylpiperidine)
  • Hazard SymbolsIrritantXi
  • SynonymsIrritantXi
  • Article Data11

4-Chloro-N-methylpiperidine Synthetic route

106-52-5

N-methyl-4-hydroxypiperidine

5570-77-4

4-chloro-1-methylpiperidine

Conditions
ConditionsYield
With thionyl chloride; triethylamine In dichloromethane at 20 - 40℃; for 2h;80%
With thionyl chloride; benzene
With thionyl chloride
931-20-4

1-methylpiperidin-2-one

103057-10-9

4-chloromethyl-1-tritylimidazole

5570-77-4

4-chloro-1-methylpiperidine

Conditions
ConditionsYield
With n-butyllithium; ammonia; diisopropylamine In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate52%
With n-butyllithium; ammonia; diisopropylamine In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate52%
1445-73-4

1-Methyl-4-piperidone

5570-77-4

4-chloro-1-methylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel / 125 °C / 102971 Torr / Hydrogenation
2: benzene; thionyl chloride
View Scheme
25012-72-0

ethyl 1-methyl-4-oxo-piperidin-3-carboxylate

5570-77-4

4-chloro-1-methylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; hydrochloric acid
2: Raney nickel / 125 °C / 102971 Torr / Hydrogenation
3: benzene; thionyl chloride
View Scheme
6315-60-2

3,3'-methylimino-di-propionic acid diethyl ester

5570-77-4

4-chloro-1-methylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaH; benzene
2: water; hydrochloric acid
3: Raney nickel / 125 °C / 102971 Torr / Hydrogenation
4: benzene; thionyl chloride
View Scheme
5382-23-0

4-chloro-N-methyl-piperidine hydrochloride

5570-77-4

4-chloro-1-methylpiperidine

Conditions
ConditionsYield
With potassium hydroxide
With ammonia
With potassium carbonate In water14 g
5570-77-4

4-chloro-1-methylpiperidine

2222-33-5

dibenzosuberenon

3967-32-6

5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol

Conditions
ConditionsYield
Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran for 5h; Reflux; Inert atmosphere;
Stage #2: With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.75h; Inert atmosphere;
Stage #3: dibenzosuberenon In tetrahydrofuran; diethyl ether at 0℃; for 2h; Inert atmosphere;		99%
Stage #1: 4-chloro-1-methylpiperidine With magnesium In tetrahydrofuran at 60 - 65℃; for 1h; Inert atmosphere; Large scale;
Stage #2: dibenzosuberenon In tetrahydrofuran at 5 - 20℃; for 1h; Temperature; Inert atmosphere; Large scale;
5570-77-4

4-chloro-1-methylpiperidine

91759-32-9

2-Thiobarbituric acid

2-<(1-Methylpiperidin-4-yl)sulfanyl>pyrimidine-4,6-diol hydrochloride

Conditions
ConditionsYield
In acetone for 1h; Ambient temperature;94%
5570-77-4

4-chloro-1-methylpiperidine

4-chloro-1-formylpiperidine

Conditions
ConditionsYield
With [2,2]bipyridinyl; C10H16NO; copper(II) bis(trifluoromethanesulfonate); copper(l) chloride In acetonitrile at 20℃; for 2h;91%
5570-77-4

4-chloro-1-methylpiperidine

957199-68-7

C15H15N3O2

1182125-60-5

1-[2-(dimethylamino)ethyl]-4-hydroxy-4-(1-methylpiperidin-4-yl)-1H-pyrrolo[3,2-g]isoquinolin-9(4H)-one

Conditions
ConditionsYield
Stage #1: 4-chloro-1-methylpiperidine With magnesium In tetrahydrofuran for 1h; Inert atmosphere; Reflux;
Stage #2: C15H15N3O2 In tetrahydrofuran at 0℃; Inert atmosphere; Reflux;		85%

4-Chloro-N-methylpiperidine Chemical Properties


IUPAC Name: 4-Chloro-1-methylpiperidine
Canonical SMILES: CN1CCC(CC1)Cl
InChI: InChI=1S/C6H12ClN/c1-8-4-2-6(7)3-5-8/h6H,2-5H2,1H3
InChIKey: MYGXGCCFTPKWIH-UHFFFAOYSA-N
Molecular Weight: 133.61918 [g/mol]
Molecular Formula: C6H12ClN
XLogP3-AA: 1.4
H-Bond Donor: 0
H-Bond Acceptor: 1 
EINECS: 226-942-4
Melting Point: 160-165 °C
Index of Refraction: 1.482
Molar Refractivity: 36.47 cm3
Molar Volume: 127.8 cm3
Surface Tension: 31.9 dyne/cm
Density: 1.04 g/cm3
Flash Point: 54 °C
Enthalpy of Vaporization: 40.22 kJ/mol
Boiling Point: 165.7 °C at 760 mmHg
Vapour Pressure: 1.85 mmHg at 25 °C
Product Categories of 4-Chloro-N-methylpiperidine (CAS NO.5570-77-4): PHARMACEUTICAL INTERMEDIATES; Heterocyclic Compounds

4-Chloro-N-methylpiperidine Uses

  4-Chloro-N-methylpiperidine (CAS NO.5570-77-4) is an important Pharmaceutical intermediates, used  for the antihistamine.

4-Chloro-N-methylpiperidine Safety Profile

Safety Information of 4-Chloro-N-methylpiperidine (CAS NO.5570-77-4):
Hazard Codes : Xi
Safety Statements : 22-24/25
22:Do not breathe dust 
24/25:Avoid contact with skin and eyes 

4-Chloro-N-methylpiperidine Specification

 4-Chloro-N-methylpiperidine (CAS NO.5570-77-4), its Synonyms are 4-Chloro-N-methylpiperidine hydrochloride ; Piperidine, 4-chloro-1-methyl- ; 4-Chloro-1-methylpiperidine .

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