Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
4-Hydroxyindole |
EINECS | 219-177-2 |
CAS No. | 2380-94-1 | Density | 1.327 g/cm3 |
PSA | 36.02000 | LogP | 1.87350 |
Solubility | slightly soluble | Melting Point |
97-99 °C(lit.) |
Formula | C8H7NO | Boiling Point | 343.2 °C at 760 mmHg |
Molecular Weight | 133.15 | Flash Point | 161.4 °C |
Transport Information | N/A | Appearance | off-white cyrstalline solid |
Safety | 26-36/37/39 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
1,5-Dihydro-indol-4-one;1,5-dihydroindol-4-one;1H-Indol-4-ol;4-Hydroxy Indole (4-Indolol);4-hydroxy-1H-indole;4-Hydroxy Indole; |
Article Data | 40 |
3-nitro-2-vinylphenol
1H-indol-4-ol
Conditions | Yield |
---|---|
With carbon monoxide; triphenylphosphine; palladium diacetate In acetonitrile under 3040 Torr; Heating; | 96% |
With carbon monoxide; palladium diacetate; triphenylphosphine In acetonitrile at 90℃; under 3051.25 Torr; for 50h; | 96% |
(4-Hydroxy-indol-1-yl)-phenyl-methanone
1H-indol-4-ol
Conditions | Yield |
---|---|
With potassium hydroxide at 0 - 20℃; for 2h; | 96% |
1H-indol-4-ol
Conditions | Yield |
---|---|
With sodium hydroxide at 0℃; for 1h; | 95% |
4-benzyloxy-1H-indole
1H-indol-4-ol
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 775.743 Torr; for 12h; | 89.4% |
With methanol; magnesium hydrosilicate; palladium Hydrogenation; |
4-hydroxyindoline
1H-indol-4-ol
Conditions | Yield |
---|---|
With palladium on activated charcoal In o-xylene for 2.3h; Heating; | 88% |
Conditions | Yield |
---|---|
With hydrogen; 5% rhodium-on-charcoal; nickel(II) nitrate In tetrahydrofuran; water at 20℃; for 32h; | A 6% B 88% |
With hydrogen; 5% rhodium-on-charcoal; iron(II) acetate In tetrahydrofuran at 20℃; for 31h; | A 5% B 83% |
With hydrogen; 5% rhodium-on-charcoal; tris(acetylacetonato)cobalt In tetrahydrofuran at 20℃; for 38h; | A 3% B 80% |
4-acetoxy-N-tosylindole
1H-indol-4-ol
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 12h; Heating; | 83% |
2-(2-benzyloxy-6-nitrophenyl)acetonitrile
1H-indol-4-ol
Conditions | Yield |
---|---|
With hydrogen; acetic acid; 10% palladium on active carbon In ethanol under 2280 Torr; for 2h; Ambient temperature; | 81% |
With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol | 78% |
Conditions | Yield |
---|---|
With ethene; 5%-palladium/activated carbon; ammonium acetate In acetonitrile at 90℃; under 760.051 Torr; for 15h; Reagent/catalyst; Schlenk technique; | A 11% B 80% |
ethyl 4-hydroxy-1H-indole-1-carboxylate
1H-indol-4-ol
Conditions | Yield |
---|---|
palladium on activated charcoal | 75% |
IUPAC Name: 1H-indol-4-ol
Synonyms of 4-Hydroxyindole (CAS NO.2380-94-1): 4-Indolol
CAS NO: 2380-94-1
Molecular Formula: C8H7NO
Molecular Weight: 133.15
Molecular Structure:
EINECS: 219-177-2
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 14.16 Å2
Index of Refraction: 1.739
Molar Refractivity: 40.41 cm3
Molar Volume: 100.3 cm3
Surface Tension: 65.8 dyne/cm
Density: 1.327 g/cm3
Flash Point: 161.4 °C
Enthalpy of Vaporization: 61.03 kJ/mol
Boiling Point: 343.2 °C at 760 mmHg
Vapour Pressure: 3.61E-05 mmHg at 25°C
Melting Point: 97-99 °C(lit.)
Storage temp: 0-6°C
Water Solubility: slightly soluble
Sensitive: Air Sensitive
Appearance: Off-White Cyrstalline Solid
SMILES: c1cc2c(cc[nH]2)c(c1)O
InChI: InChI=1/C8H7NO/c10-8-3-1-2-7-6(8)4-5-9-7/h1-5,9-10H
InChIKey: NLMQHXUGJIAKTH-UHFFFAOYAU
Std. InChI: InChI=1S/C8H7NO/c10-8-3-1-2-7-6(8)4-5-9-7/h1-5,9-10H
Std. InChIKey: NLMQHXUGJIAKTH-UHFFFAOYSA-N
Product Categories of 4-Hydroxyindole (CAS NO.2380-94-1): blocks;IndolesOxindoles;Indoles and derivatives;pharmacetical;Heterocycles series;Pyrroles & Indoles;Indole;Indoles;Indole Derivatives;Simple Indoles;Chiral Compound;Pyrroles & Indoles
4-Hydroxyindole (CAS NO.2380-94-1) is used for pharmaceutical intermediates.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store 4-Hydroxyindole (CAS NO.2380-94-1) in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4°C/39°F.) Store under nitrogen.