CAS No.43210-67-9,Fenbendazole Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	43210-67-9
Name:	Fenbendazole
Article Data:	13

Formula:	C₁₅H₁₃N₃O₂S
Molecular Weight:	299.353
Synonyms:	Carbamicacid, [5-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (9CI);2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole;Axilur;Fenbendazol;Fenbion;HOE 881;Methyl5-(phenylthio)-2-benzimidazolecarbamate;Methyl[5-(phenylthio)-1H-benzimidazol-2-yl]carbamate;Panacur;Safe-Guard;
EINECS:	256-145-7
Density:	1.4 g/cm³
Melting Point:	233 °C
Solubility:	Insoluble in water
Appearance:	Off-white solid
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	92.31000
LogP:	3.96540

Synthetic route

: 43156-48-5
1,2-diamino-4-phenylthiobenzene

: 867-44-7
S-Methylisothiourea sulfate

: 79-22-1
methyl chloroformate

: 43210-67-9
Fenbendazole

Conditions

Conditions	Yield
Stage #1: S-Methylisothiourea sulfate; methyl chloroformate With sodium hydroxide In water at 3 - 6℃; for 0.666667h; Stage #2: 1,2-diamino-4-phenylthiobenzene With acetic acid In ethanol; water at 95℃; for 24h;	88%

...Expand

: 43156-47-4
2-nitro-5-phenylthioaniline

: 43210-67-9
Fenbendazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 2.1: NaOH / H2O / 0.67 h / 3 - 6 °C 2.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme

: 1635-61-6
5-chloro-2-nitroaniline

: 43210-67-9
Fenbendazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: K2CO3 / dimethylformamide / 6 h / Heating 2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 3.1: NaOH / H2O / 0.67 h / 3 - 6 °C 3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme

: 108-98-5
thiophenol

: 43210-67-9
Fenbendazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: K2CO3 / dimethylformamide / 6 h / Heating 2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 3.1: NaOH / H2O / 0.67 h / 3 - 6 °C 3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme

(5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of: (5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of

: 43210-67-9
Fenbendazole

Conditions

Conditions	Yield
With chicken alkaline phosphatase In water at 39℃; pH=6.5 - 9.0; Enzyme kinetics;
With porcine alkaline phosphatase In water at 37℃; pH=6.5 - 9.0; Enzyme kinetics;

: 43210-67-9
Fenbendazole

: 53716-50-0, 122063-22-3, 122063-23-4
oxfendazole

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium sulfite In methanol; water	98.8%
With urea hydrogen peroxide adduct In formic acid; water at 25 - 45℃; for 5.5h; Temperature; Concentration;	98%

: 43210-67-9
Fenbendazole

: 53065-28-4
5-(phenylthio)-1H-benzo[d]imidazol-2-amine

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water for 48h; Heating;	98%
In N,N-dimethyl-formamide for 12h; Heating;	50%

: 541-41-3
chloroformic acid ethyl ester

: 43210-67-9
Fenbendazole

A: 58521-88-3
2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester

B: 58522-05-7
2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane Ambient temperature;

...Expand

: 79-22-1
methyl chloroformate

: 43210-67-9
Fenbendazole

A: 58521-87-2
methyl 1-methoxycarbonyl-5-phenylthiobenzimidazole-2-carbamate

B: 58522-04-6
2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid methyl ester

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane for 20h; Ambient temperature;	A 12 g B 8 g

...Expand

: 43210-67-9
Fenbendazole

: 2941-64-2
Ethyl chlorothioformate

A: 104663-11-8
2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carbothioic acid S-ethyl ester

B: 104663-33-4
2-Oxo-5-phenylsulfanyl-benzoimidazole-1,3-dicarbothioic acid di-S-ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane Ambient temperature;

...Expand

Raw Materials

108-98-5

43156-47-4

1635-61-6

43156-48-5

79-22-1

867-44-7

Downstream Products

53716-50-0

Total:234 Page 1 of 7 1 2 3 4 5 6 …7 Next>>

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Chemistry

IUPAC:methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
CAS:43210-67-9
The Molecular formula of Fenbendazole(43210-67-9):C₁₅H₁₃N₃O₂S
The Molecular Weight of Fenbendazole(43210-67-9):299.35
Synonyms:[5-(PHENYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;HOE-881V;FENBENDAZOLE;METHYL 5-(PHENYLTHIO)-2-BENZIMIDAZOLECARBAMATE;SAFEGARD;PANACUR;(5-(phenylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester;5-(phenylthio)-2-benzimidazolecarbamicacimethylester
EINECS:256-145-7
Density:1.4g/cm³
Melting Point:233^oC
Appearance:white to yellowish powder
Product Categories:PHARMACEUTICALS;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries
Mol File:43210-67-9.mol
storage temp.:0-6^oC

Uses

Fenbendazole(43210-67-9) is known as a kind of benzimidazole anthelmintics. It is regularly used to eliminate numerous gastrointestinal parasites from animals,and it is quite effective against roundworms, hookworms, whipworms, certain tapeworms and parasites called strongyles and strongyloides.

Toxicity Data With Reference

1.		oth:hmn:lym 100 mg/L		ENMUDM Environmental Mutagenesis. 2 (1980),67.
2.		oth:hmn:leu 1 mg/L		THERAP Therapie. 31 (1976),505.

Safety Profile

Human mutation data reported. When heated to decomposition it emits toxic fumes of SO_x and NO_x.

Safty informations about Fenbendazole(43210-67-9):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38(Irritating to eyes, respiratory system and skin)
Safety Statements:26-36
26(In case of contact with eyes, rinse immediately with plenty of water and seek medical advice)
36(Wear suitable protective clothing)
WGK Germany:2
RTECS:DD6520500

Specification

Storage:Keep tightly closed.