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| CAS No.: | 43210-67-9 |
|---|---|
| Name: | Fenbendazole |
| Article Data: | 13 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C15H13N3O2S |
| Molecular Weight: | 299.353 |
| Synonyms: | Carbamicacid, [5-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (9CI);2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole;Axilur;Fenbendazol;Fenbion;HOE 881;Methyl5-(phenylthio)-2-benzimidazolecarbamate;Methyl[5-(phenylthio)-1H-benzimidazol-2-yl]carbamate;Panacur;Safe-Guard; |
| EINECS: | 256-145-7 |
| Density: | 1.4 g/cm3 |
| Melting Point: | 233 °C |
| Solubility: | Insoluble in water |
| Appearance: | Off-white solid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 92.31000 |
| LogP: | 3.96540 |
- 43212-41-5Pyrimidine,2,4-dichloro-6-methoxy-
- 43216-12-22H-Pyran,tetrahydro-2-(iodomethyl)-
- 43216-72-41,3-Benzenediamine,4-chloro-6-methyl-
- 4321-69-12,7-Naphthalenedisulfonicacid, 5-(acetylamino)-3-[2-[4-(acetylamino)phenyl]diazenyl]-4-hydroxy-, sodiumsalt (1:2)
- 43217-07-8PK 4255
- 43217-28-3Anthracene,2-chloro-9,10-diphenyl-
- 43217-31-8Anthracene,9,10-bis(4-methylphenyl)-
- 43218-56-02-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide monohydrochloride
- 432-21-3Benzenamine,3-chloro-2-(trifluoromethyl)-
- 43222-48-6AVENGE
- 43156-48-5
1,2-diamino-4-phenylthiobenzene
- 867-44-7
S-Methylisothiourea sulfate
- 79-22-1
methyl chloroformate
- 43210-67-9
Fenbendazole
| Conditions | Yield |
|---|---|
| Stage #1: S-Methylisothiourea sulfate; methyl chloroformate With sodium hydroxide In water at 3 - 6℃; for 0.666667h; Stage #2: 1,2-diamino-4-phenylthiobenzene With acetic acid In ethanol; water at 95℃; for 24h; | 88% |
- 43156-47-4
2-nitro-5-phenylthioaniline
- 43210-67-9
Fenbendazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 2.1: NaOH / H2O / 0.67 h / 3 - 6 °C 2.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme |
- 1635-61-6
5-chloro-2-nitroaniline
- 43210-67-9
Fenbendazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: K2CO3 / dimethylformamide / 6 h / Heating 2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 3.1: NaOH / H2O / 0.67 h / 3 - 6 °C 3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme |
- 108-98-5
thiophenol
- 43210-67-9
Fenbendazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: K2CO3 / dimethylformamide / 6 h / Heating 2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 3.1: NaOH / H2O / 0.67 h / 3 - 6 °C 3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme |
- (5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of
(5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of
- 43210-67-9
Fenbendazole
| Conditions | Yield |
|---|---|
| With chicken alkaline phosphatase In water at 39℃; pH=6.5 - 9.0; Enzyme kinetics; | |
| With porcine alkaline phosphatase In water at 37℃; pH=6.5 - 9.0; Enzyme kinetics; |
- 43210-67-9
Fenbendazole
- 53716-50-0, 122063-22-3, 122063-23-4
oxfendazole
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide; sodium sulfite In methanol; water | 98.8% |
| With urea hydrogen peroxide adduct In formic acid; water at 25 - 45℃; for 5.5h; Temperature; Concentration; | 98% |
- 43210-67-9
Fenbendazole
- 53065-28-4
5-(phenylthio)-1H-benzo[d]imidazol-2-amine
| Conditions | Yield |
|---|---|
| With potassium hydroxide In methanol; water for 48h; Heating; | 98% |
| In N,N-dimethyl-formamide for 12h; Heating; | 50% |
- 541-41-3
chloroformic acid ethyl ester
- 43210-67-9
Fenbendazole
A
- 58521-88-3
2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester
B
- 58522-05-7
2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane Ambient temperature; |
- 79-22-1
methyl chloroformate
- 43210-67-9
Fenbendazole
A
- 58521-87-2
methyl 1-methoxycarbonyl-5-phenylthiobenzimidazole-2-carbamate
B
- 58522-04-6
2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid methyl ester
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane for 20h; Ambient temperature; | A 12 g B 8 g |
- 43210-67-9
Fenbendazole
- 2941-64-2
Ethyl chlorothioformate
A
- 104663-11-8
2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carbothioic acid S-ethyl ester
B
- 104663-33-4
2-Oxo-5-phenylsulfanyl-benzoimidazole-1,3-dicarbothioic acid di-S-ethyl ester
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane Ambient temperature; |
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Chemistry
IUPAC:methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
CAS:43210-67-9
The Molecular formula of Fenbendazole(43210-67-9):C15H13N3O2S
The Molecular Weight of Fenbendazole(43210-67-9):299.35
Synonyms:[5-(PHENYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;HOE-881V;FENBENDAZOLE;METHYL 5-(PHENYLTHIO)-2-BENZIMIDAZOLECARBAMATE;SAFEGARD;PANACUR;(5-(phenylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester;5-(phenylthio)-2-benzimidazolecarbamicacimethylester
EINECS:256-145-7
Density:1.4g/cm3
Melting Point:233oC
Appearance:white to yellowish powder
Product Categories:PHARMACEUTICALS;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries
Mol File:43210-67-9.mol
storage temp.:0-6oC
Uses
Fenbendazole(43210-67-9) is known as a kind of benzimidazole anthelmintics. It is regularly used to eliminate numerous gastrointestinal parasites from animals,and it is quite effective against roundworms, hookworms, whipworms, certain tapeworms and parasites called strongyles and strongyloides.
Toxicity Data With Reference
| 1. | oth:hmn:lym 100 mg/L | ENMUDM Environmental Mutagenesis. 2 (1980),67. | ||
| 2. | oth:hmn:leu 1 mg/L | THERAP Therapie. 31 (1976),505. |
Safety Profile
Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safty informations about Fenbendazole(43210-67-9):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38(Irritating to eyes, respiratory system and skin)
Safety Statements:26-36
26(In case of contact with eyes, rinse immediately with plenty of water and seek medical advice)
36(Wear suitable protective clothing)
WGK Germany:2
RTECS:DD6520500