- 4-Thiazolecarboxylic acid
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- 4-Thiazolecarboxylicacid, 2-(4-bromophenyl)-, ethyl ester
- 4-Thiazolecarboxylicacid, 2-(4-fluorophenyl)-
- 4-Thiazolecarboxylicacid, 2-(4-methylphenyl)-
- 4-Thiazolecarboxylicacid, 2-(4-morpholinyl)-
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Cas Database |
| Name |
4-Thiazolecarboxylic acid |
EINECS | 628-056-7 |
| CAS No. | 3973-08-8 | Density | 1.525 g/cm3 |
| PSA | 78.43000 | LogP | 0.84130 |
| Solubility | N/A | Melting Point |
195-199 °C(lit.) |
| Formula | C4H3NO2S | Boiling Point | 319.2 °C at 760 mmHg |
| Molecular Weight | 129.139 | Flash Point | 146.9 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 36/37 | Risk Codes | 43 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
1,3-Thiazole-4-carboxylicacid;NSC 195467; |
Article Data | 25 |
4-Thiazolecarboxylic acid Synthetic route
- 59418-09-6
4-thiazolecarboxylate methyl ester
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 1h; Reflux; | 96.1% |
| Conditions | Yield |
|---|---|
| Stage #1: ethyl Bromopyruvate; thiourea In water at 40℃; for 5h; Stage #2: With hydrogenchloride; sodium nitrite In water for 2h; Temperature; Concentration; | 94% |
| Conditions | Yield |
|---|---|
| at 30℃; for 16h; Pseudomonas putida ATCC 33015; | 80% |
| With potassium permanganate In water at 55℃; for 22h; Reagent/catalyst; Temperature; | 70.2% |
- 1113-59-3
bromopyruvic acid
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: formamide With tetraphosphorus decasulfide In tetrahydrofuran at 30℃; for 3h; Stage #2: bromopyruvic acid In tetrahydrofuran at 40 - 50℃; for 3h; | 22% |
- 635-46-1
1,2,3,4-tetrahydroisoquinoline
- 22358-80-1
thiazole 2,5-dicarboxylic acid
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| at 153.9℃; Rate constant; sowie bei 164.7.Decarboxylation; |
- 100367-77-9
ethyl 2-bromothiazole-4-carboxylate
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With potassium hydroxide anschliessend Hydrieren an Raney-Nickel; |
- 89791-92-4
2-propionyl-thiazole-4-carboxylic acid
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With sulfuric acid at 180℃; |
- 89791-92-4
2-propionyl-thiazole-4-carboxylic acid
A
- 3973-08-8
Thiazole-4-carboxylic acid
B
- 89379-29-3
thiazole-2,4-dicarboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide; potassium permanganate |
- 89379-29-3
thiazole-2,4-dicarboxylic acid
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| at 140 - 144℃; Decarboxylation; |
4-Thiazolecarboxylic acid Chemical Properties
IUPAC Name: 1,3-thiazole-4-carboxylic acid (3973-08-8)
Synonyms: 1,3-Thiazole-4-carboxylic acid ; Akos bb-9161 ; 4-Carboxythiazole ; 4-Thiazolecarboxylic acid ; Timtec-bb sbb010166 ; Thiazole-4-carboxylic acid ; 4-Thiazolecarboxylic acid 3973-8-8 ; 1,3-Thiazole-4-carboxylic acid 3973-8-8
CAS: 3973-08-8
MF: C4H3NO2S
MW: 129.14
MS:
Product Categories: blocks ; Carboxes ; Thiazoles ; Sulphur Derivatives ; Carboxylic Acids ; Thiazoles, Isothiazoles &Benzothiazoles ; Carboxylic Acids ; Thiazoles, Isothiazoles & Benzothiazoles ; Building Blocks ; Heterocyclic Building Blocks
Mol File: 3973-08-8.mol
Surface Tension: 72 dyne/cm Density: 1.525 g/cm3
Flash Point: 146.9 °C Enthalpy of Vaporization: 59.21 kJ/mol
Boiling Point: 319.2 °C at 760 mmHg Vapour Pressure: 0.000143 mmHg at 25°C
MP:195-199 °C(lit.)
4-Thiazolecarboxylic acid Uses
1.4-Thiazolecarboxylic acid (93973-08-8) is an intermediate of fungicide thiabendazole.
2.4-Thiazolecarboxylic acid (93973-08-8) is used as a medicine, pesticide intermediates, organic synthesis reagents .
4-Thiazolecarboxylic acid Production
Its preparation method is to use formamide with P2S5 in ethylene glycol dimethyl ether (CH3OCH2CH2OCH3) reaction to obtain thiocarboxamide (HCSNH2), and then, halogenate with pyruvate for product.
4-Thiazolecarboxylic acid Safety Profile
Hazard Codes: Xi .gif){kind=small}
Risk Statements: 43
43: 4-Thiazolecarboxylic acid (93973-08-8) may cause sensitization by skin contact
Safety Statements : 36/37
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
4-Thiazolecarboxylic acid Specification
4-Thiazolecarboxylic acid (93973-08-8) is a colorless solid, not dissolve in water.
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