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| CAS No.: | 3973-08-8 |
|---|---|
| Name: | 4-Thiazolecarboxylic acid |
| Article Data: | 25 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H3NO2S |
| Molecular Weight: | 129.139 |
| Synonyms: | 1,3-Thiazole-4-carboxylicacid;NSC 195467; |
| EINECS: | 628-056-7 |
| Density: | 1.525 g/cm3 |
| Melting Point: | 195-199 °C(lit.) |
| Boiling Point: | 319.2 °C at 760 mmHg |
| Flash Point: | 146.9 °C |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 43 |
| Safety: | 36/37 |
| PSA: | 78.43000 |
| LogP: | 0.84130 |
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- 59418-09-6
4-thiazolecarboxylate methyl ester
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 1h; Reflux; | 96.1% |
| Conditions | Yield |
|---|---|
| Stage #1: ethyl Bromopyruvate; thiourea In water at 40℃; for 5h; Stage #2: With hydrogenchloride; sodium nitrite In water for 2h; Temperature; Concentration; | 94% |
| Conditions | Yield |
|---|---|
| at 30℃; for 16h; Pseudomonas putida ATCC 33015; | 80% |
| With potassium permanganate In water at 55℃; for 22h; Reagent/catalyst; Temperature; | 70.2% |
- 1113-59-3
bromopyruvic acid
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: formamide With tetraphosphorus decasulfide In tetrahydrofuran at 30℃; for 3h; Stage #2: bromopyruvic acid In tetrahydrofuran at 40 - 50℃; for 3h; | 22% |
- 635-46-1
1,2,3,4-tetrahydroisoquinoline
- 22358-80-1
thiazole 2,5-dicarboxylic acid
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| at 153.9℃; Rate constant; sowie bei 164.7.Decarboxylation; |
- 100367-77-9
ethyl 2-bromothiazole-4-carboxylate
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With potassium hydroxide anschliessend Hydrieren an Raney-Nickel; |
- 89791-92-4
2-propionyl-thiazole-4-carboxylic acid
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| With sulfuric acid at 180℃; |
- 89791-92-4
2-propionyl-thiazole-4-carboxylic acid
A
- 3973-08-8
Thiazole-4-carboxylic acid
B
- 89379-29-3
thiazole-2,4-dicarboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide; potassium permanganate |
- 89379-29-3
thiazole-2,4-dicarboxylic acid
- 3973-08-8
Thiazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
| at 140 - 144℃; Decarboxylation; |
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Chemistry
IUPAC Name: 1,3-thiazole-4-carboxylic acid (3973-08-8)
Synonyms: 1,3-Thiazole-4-carboxylic acid ; Akos bb-9161 ; 4-Carboxythiazole ; 4-Thiazolecarboxylic acid ; Timtec-bb sbb010166 ; Thiazole-4-carboxylic acid ; 4-Thiazolecarboxylic acid 3973-8-8 ; 1,3-Thiazole-4-carboxylic acid 3973-8-8
CAS: 3973-08-8
MF: C4H3NO2S
MW: 129.14
MS:
Product Categories: blocks ; Carboxes ; Thiazoles ; Sulphur Derivatives ; Carboxylic Acids ; Thiazoles, Isothiazoles &Benzothiazoles ; Carboxylic Acids ; Thiazoles, Isothiazoles & Benzothiazoles ; Building Blocks ; Heterocyclic Building Blocks
Mol File: 3973-08-8.mol
Surface Tension: 72 dyne/cm Density: 1.525 g/cm3
Flash Point: 146.9 °C Enthalpy of Vaporization: 59.21 kJ/mol
Boiling Point: 319.2 °C at 760 mmHg Vapour Pressure: 0.000143 mmHg at 25°C
MP:195-199 °C(lit.)
Uses
1.4-Thiazolecarboxylic acid (93973-08-8) is an intermediate of fungicide thiabendazole.
2.4-Thiazolecarboxylic acid (93973-08-8) is used as a medicine, pesticide intermediates, organic synthesis reagents .
Production
Its preparation method is to use formamide with P2S5 in ethylene glycol dimethyl ether (CH3OCH2CH2OCH3) reaction to obtain thiocarboxamide (HCSNH2), and then, halogenate with pyruvate for product.
Safety Profile
Hazard Codes: Xi .gif){kind=small}
Risk Statements: 43
43: 4-Thiazolecarboxylic acid (93973-08-8) may cause sensitization by skin contact
Safety Statements : 36/37
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
Specification
4-Thiazolecarboxylic acid (93973-08-8) is a colorless solid, not dissolve in water.