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7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

  • Name 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
  • EINECS429-400-7
  • CAS No. 199327-61-2
  • Density1.327 g/cm3
  • PSA76.68000
  • LogP0.97070
  • SolubilityN/A
  • Melting Point233-236 °C
  • FormulaC16H21N3O4
  • Boiling Point519.53 °C at 760 mmHg
  • Molecular Weight319.36
  • Flash Point268.002 °C
  • Transport InformationN/A
  • AppearanceN/A
  • Safety
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 199327-61-2 (7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one)
  • Hazard SymbolsN/A
  • SynonymsN/A
  • Article Data25

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Synthetic route

C9H6N2O3(2-)*2Na(1+)

125422-83-5

4 (3-bromopropyl)-morpholine

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 65 - 70℃; for 5h;93.8%
7357-67-7

4-(3-chloropropyl)morpholine

C9H6N2O3(2-)*2K(1+)

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 55 - 60℃; for 5h;93.7%
1417436-51-1

4-(3-iodopropyl)morpholine

C9H6N2O3(2-)*2K(1+)

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 75 - 80℃; for 5h;91.2%
3473-63-0

formamidine acetic acid

214472-41-0

methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In ethanol for 4h; Reflux;88%
In methanol at 50 - 60℃; for 6h;81.73%
In 2-methoxy-ethanol at 115℃; for 2h;78%
In methanol at 50 - 60℃; for 6h;
246512-44-7

2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

50-00-0

formaldehyd

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In water at 130℃; for 48h;88%
1208902-96-8

7-methoxy-6-(3'-N-morpholino)propoxyquinazoline

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: 7-methoxy-6-(3'-N-morpholino)propoxyquinazoline With ammonium cerium (IV) nitrate; acetic acid In water
Stage #2: With sodium hydroxide In water
87%
With peracetic acid; sulfuric acid In ethanol at 60℃; for 12h;85%
675126-26-8

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

64-18-6

formic acid

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Heating;
Stage #2: formic acid With hydrogenchloride In water at 90 - 130℃; Further stages.;
86%
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water at 80℃; for 3.5h;
Stage #2: formic acid With hydrogenchloride In water at 130℃; for 4h;
68.65%
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Reflux;
Stage #2: formic acid With hydrogenchloride In water at 130℃; for 3.5h;
58%

C16H20N2O6

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With formamidine acetic acid82%
246512-44-7

2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

64-18-6

formic acid

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid With formamide at 20 - 100℃;
Stage #2: at 100℃; for 7h;
78%
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid In dichloromethane at 100℃; for 5h; Acidic conditions;
Stage #2: With hydrogenchloride In water at 70℃; for 3h; Acidic aqueous solution;
Stage #3: With sodium hydroxide In water at 20 - 25℃; Alkaline aqueous solution;
With formamide at 20℃; for 8h; Reflux;3.3 g
214472-41-0

methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate

199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
at 170℃; for 3h;71.1%

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Chemical Properties

Molecular structure of 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one (CAS NO.199327-61-2) is:

Product Name: 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 
Empirical Formula: C16H21N3O4
Molecular Weight: 319.3556
CAS Registry Number: 199327-61-2
Index of Refraction: 1.611
Molar Refractivity: 83.535 cm3
Molar Volume: 240.745 cm3
Surface Tension: 49.021 dyne/cm
Density: 1.327 g/cm3
Flash Point: 268.002 °C
Enthalpy of Vaporization: 79.231 kJ/mol
Boiling Point: 519.53 °C at 760 mmHg
Product Categories: Heterocycles; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Uses

 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one (CAS NO.199327-61-2) can be used as Gefitinib intermediate.

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Specification

 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one , its cas register number is 199327-61-2. It also can be called 7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(1H)-one ; 7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one ; 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone .

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