1. Introduction of Abacavir
Abacavir is one kind of white powder. Its IUPAC name is called [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol. It belongs to classification codes which are Anti-HIV Agents, Anti-Infective Agents, Anti-Retroviral Agents, Antiviral Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors, Reverse Transcriptase Inhibitors. Besides, its Product Categories is Bases & Related Reagents;Inhibitors;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals. It should be store at refrigerator. Abacavir can be soluble in water. Its Classification Codes is Anti-HIV Agents; Anti-Infective Agents; Anti-Retroviral Agents; Antiviral Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors.

2. Properties of Abacavir
Physical properties about Abacavir are:
(1) ACD/LogP: -0.78 ; (2) # of Rule of 5 Violations: 0 ; (3) ACD/LogD (pH 7.4): 0.66 ; (4) ACD/BCF (pH 5.5): 1 ; (5) ACD/BCF (pH 7.4): 1.8 ; (6) ACD/KOC (pH 5.5): 4.47 ; (7) ACD/KOC (pH 7.4): 50.77 ; (8) #H bond acceptors: 7 ; (9) #H bond donors: 4 ; (10) #Freely Rotating Bonds: 4 ; (11) Polar Surface Area: 59.31 Å² ; (12) Index of Refraction: 1.864 ; (13) Molar Refractivity: 75.8 cm³ ; (14) Molar Volume: 167.6 cm³ ; (15) Surface Tension: 80.1 dyne/cm ; (16) Density: 1.7 g/cm³ ; (17) Flash Point: 338.4 °C ; (18) Enthalpy of Vaporization: 98.77 kJ/mol ; (19) Boiling Point: 636 °C at 760 mmHg ; (20) Vapour Pressure: 4.77E-17 mmHg at 25°C.

3. Structure Descriptors of Abacavir
(1) SMILES:n3c1c(ncn1[C@H]2/C=C\[C@@H](CO)C2)c(nc3N)NC4CC4;
(2) InChI:InChI=1/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1;
(3) InChIKey:MCGSCOLBFJQGHM-SCZZXKLOBP

4. Uses of Abacavir
Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. This compound has been used as a drug with the trade name of Ziagen. It is a kind of antiretroviral drugs approved by the Food and Drug Administration (FDA). It has tablets and oral solution. This drug is used to treat HIV and AIDS in combination with other antiretroviral agents. It can be used for research and manufacture Epzicom tablet.

5. Production of Abacavir
030-8 1.0g (0.0053mol), in the reaction flask was added cesium carbonate 1.75 g (0.0054 mol) and dry DMSO 50ml, stirred under N2 protection, the temperature was raised to 60 °C and stirred at this temperature for 2 h the mixture wascooled to room temperature, then add tetrakis (triphenylphosphine) combined palladium (TTP) [0.85 (0.00074mol)] and compound 030-5 [0.79g (0.0034 mol), DMSO (10 ml) solution was stirred and heated to 65 °C held 65 °C and stirred reaction 2.25h. The you can get the mixture containing compounds 030-9.

To the mixture was added methanol 100ml and K₂CO₃ is 2.10g, the mixture reaction was stirred for 45min at 40 °C, a solid precipitate which was filtered through a Celite layer and the filtrate was evaporated to a small volume under vacuum at 90 °C, and the remaining gum pounding mill was extracted with dichloromethane (100ml * 2) to give a brown solid residue was purified by silica gel (Merck 9385) column chromatography [eluent: dichloromethane / methanol (volume ratio 9:1)] to give a yellow foam was 030 0.26 g, yield 26.8.