cas 103475-41-8, Tepoxalin | Articles data

Articles about 103475-41-8Total 6 be found

Article title
Article abstract
Author
Journal number and time
Download

Process for preparing 1,5-diaryl-3-substituted pyrazoles
A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
-
(2008/06/13)

A Facile Synthesis of Tepoxalin, 5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide
-
Murray, William V.,Hadden, Susan K.
p. 6662 - 6663
(2007/10/02)

N-hydroxy, N-methyl propanamides
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.
-
(2008/06/13)

The regioselective synthesis of tepoxalin, 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-me thylpropanamide and related 1,5-diarylpyrazole anti-inflammatory agents
Tepoxalin, a potent anti-inflammatory agent, and its analogs can be synthesized by condensing an appropriate arylhydrazine hydrochloride and a 6-aryl-4,6-dioxohexanoic acid in alcohol with a base catalyst. These diarylpyrazolylpropanoic acids can be converted to their N-methylhydroxamic acids by generating the requisite acid chloride, and allowing it to react with N-methylhydroxylamine.
Murray,Wachter,Barton,Forero-Kelly
p. 18 - 20
(2007/10/02)

Regioselective synthesis of a 1,5-disubstituted pyrazole
A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a β-dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): STR1
-
(2008/06/13)

1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.
-
(2008/06/13)

Chemical Properties

Melting Point: 124-126°
Boiling Point: 572.991 °C at 760 mmHg
Flash Point:300.334 °C
Density: 1.27 g/cm³
Solubility:DMSO (Sparingly), Methanol (Slightly)
Storage Temp.:Hygroscopic, Refrigerator, Under Inert Atmosphere
Vapor Pressure: 5.72E-14mmHg at 25°C
Refractive Index: 1.61
PSA: 67.59000
LogP: 3.98150

Global suppliers and manufacturers of 103475-41-8total 47 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:994
Country:

Simagchem Corporation
Business Type:Manufacturers
Min Order:1 Metric Ton
FOB Price:No Data
Main Products:110
Country:

Ality Chemical Corporation
Business Type:Other
Min Order:1
FOB Price:No Data
Main Products:165
Country:

Xi'an Xszo Chem Co., Ltd.
Business Type:Manufacturers
Min Order:1 Gram
FOB Price:USD $ 0.1-0.1 / Gram
Main Products:108
Country:

LIDE PHARMACEUTICALS LIMITED
Business Type:Lab/Research institutions
Min Order:1 Milligram
FOB Price:No Data
Main Products:56
Country:

Hebei Nengqian Chemical Import and Export Co., LTD
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 9.0-99.0 / Kilogram
Main Products:165
Country:

Hangzhou Sartort Biopharma Co., Ltd
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 1.0-1.0 / Kilogram
Main Products:80
Country:

Qingdao Beluga Import and Export Co., LTD
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:117
Country:

Shandong Hanjiang Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:No Data
Main Products:78
Country:

Afine Chemicals Limited
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:95
Country:

Zibo Hangyu Biotechnology Development Co., Ltd
Business Type:Lab/Research institutions
Min Order:10 Gram
FOB Price:No Data
Main Products:313
Country:

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 2.0-2.0 / Kilogram
Main Products:90
Country:

SAGECHEM LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:33
Country:

Suzhou Health Chemicals Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:9
Country:

Kono Chem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:86
Country:

Aecochem Corp.
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:70
Country:

Xi`an Eastling Biotech Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:21
Country:

Hangzhou Huarong Pharm Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:65
Country:

Xiamen AmoyChem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:54
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 103475-41-8

Article Database

103475-41-8

Articles about 103475-41-8Total 6 be found

More Articles about upstream products of 103475-41-8

More Articles about downstream products of 103475-41-8

Chemical Properties

Melting Point: 124-126°

Boiling Point: 572.991 °C at 760 mmHg

Flash Point:300.334 °C

Density: 1.27 g/cm³

Solubility:DMSO (Sparingly), Methanol (Slightly)

Storage Temp.:Hygroscopic, Refrigerator, Under Inert Atmosphere

Vapor Pressure: 5.72E-14mmHg at 25°C

Refractive Index: 1.61

PSA: 67.59000

LogP: 3.98150

Global suppliers and manufacturers of 103475-41-8total 47 suppliers on LookChem

Article Database

103475-41-8

Articles about 103475-41-8Total 6 be found

More Articles about upstream products of 103475-41-8

More Articles about downstream products of 103475-41-8

Chemical Properties

Melting Point: 124-126°

Boiling Point: 572.991 °C at 760 mmHg

Flash Point:300.334 °C

Density: 1.27 g/cm3

Solubility:DMSO (Sparingly), Methanol (Slightly)

Storage Temp.:Hygroscopic, Refrigerator, Under Inert Atmosphere

Vapor Pressure: 5.72E-14mmHg at 25°C

Refractive Index: 1.61

PSA: 67.59000

LogP: 3.98150

Global suppliers and manufacturers of 103475-41-8total 47 suppliers on LookChem

Density: 1.27 g/cm³