10450-60-9

Basic information

• Product Name: Periodic(VII) acid
• Synonyms: UNII-AK1D44L87G;Orthoperiodic acid;Periodic acid (H5IO6)
• CAS NO: 10450-60-9
• Molecular Formula: H₅IO₆
• Molecular Weight: 227.94
• EINECS: 233-937-0
• Mol File: 10450-60-9.mol

Chemical Properties

• Melting Point: 122℃
• Boiling Point: 140°C
• Flash Point: 140°C
• Appearance: colourless crystals
• CAS DataBase Reference: Periodic(VII) acid(CAS DataBase Reference)
• NIST Chemistry Reference: Periodic(VII) acid(10450-60-9)
• EPA Substance Registry System: Periodic(VII) acid(10450-60-9)

Safety Data

• Hazard Codes: O:Oxidizing agent
• Statements: R8:; R34:
• Safety Statements: S17:; S26:; S36/37/39:; S45:
• Hazardous Substances Data: 10450-60-9(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Periodic(VII) acid is used as an oxidizing agent for the oxidation of various organic compounds. Its strong oxidizing properties allow it to effectively convert organic substrates into their corresponding oxidized forms, making it a valuable tool in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
Periodic(VII) acid is used as a precursor to other iodine compounds, which are often employed in the development of pharmaceuticals. Its ability to form a wide range of iodine-containing compounds makes it an essential component in the synthesis of certain drugs.
Used in Analytical Chemistry:
Periodic(VII) acid is used as a titrant in analytical chemistry for the determination of certain elements and compounds. Its strong oxidizing nature allows for accurate and precise measurements in various analytical techniques.
Used in Research and Development:
Due to its unique properties, Periodic(VII) acid is used in research and development settings to explore new chemical reactions and investigate its potential applications in various fields. Its instability and explosive nature under certain conditions make it an interesting subject for studying the behavior of strong oxidizing agents.
Note: When handling Periodic(VII) acid, extreme caution must be exercised due to its instability and potential to decompose explosively. Proper safety measures and protocols should be followed to ensure the safe use of this powerful oxidizing agent.

InChI:InChI:1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

Synthetic route

iodic acid (7782-68-5) → periodic acid (10450-60-9)

Conditions	Yield
In water Electrolysis; special apparatus with Pt wire net covered with PbO2 as anode and current intensity of 12 - 15A; 24h;; evapn. of anode soln. in vac. at 40 - 60°C not to dryness, addn. of some HNO3, further evapn.; crystn.; decantation of mother lye; dissolving H5IO6 in hot concd. HNO3 soln., filtration, recrystn., heating in desiccator over KOH to 40°C;;	98%
In water Electrolysis; special apparatus with Pt wire net covered with PbO2 as anode and current intensity of 12 - 15A; 24h;; evapn. of anode soln. in purified air stream at 70 - 85°C; loss by partial formation of HIO3;;
In sulfuric acid Electrolysis; 50% HIO3 soln.; anode region: clay cell with MnO2 anode; cathode region: filled with 2n H2SO4 soln., Pt cathode; current yield: 0.39%;;

calcium dimesoperiodate + ammonia (7664-41-7) → 8CaO*3I2O7 + periodic acid (10450-60-9)

Conditions	Yield
In ammonia pptn. of a solution of Ca2I2O9 with aq. NH3-solution under formation of product and H5IO6;;
In ammonia aq. ammonia=NH3; pptn. of a solution of Ca2I2O9 with aq. NH3-solution under formation of product and H5IO6;;

sodium periodate (7790-28-5) → periodic acid (10450-60-9) + sodium hydroxide (1310-73-2)

Conditions	Yield
With water
With H2O

bariumparaperiodate + nitric acid (7697-37-2) → barium(II) nitrate + periodic acid (10450-60-9)

Conditions	Yield
In nitric acid reaction of concd. HNO3 with Ba3H4(IO6)2 forms H5IO6 and Ba(NO3)2;;
In nitric acid aq. HNO3; reaction of concd. HNO3 with Ba3H4(IO6)2 forms H5IO6 and Ba(NO3)2;;

Cs(1+)*H4IO6(1-)*H5IO6=CsH4IO6*H5IO6 → cesium periodate (13478-04-1) + periodic acid (10450-60-9)

Conditions	Yield
In neat (no solvent) at room temp. in vac.;

Cs(1+)*H4IO6(1-)*H5IO6*0.5H2O=CsH4IO6*H5IO6*0.5H2O → cesium periodate (13478-04-1) + periodic acid (10450-60-9)

Conditions	Yield
In neat (no solvent) at room temp. in vac.;

chromium(III) nitrate nonahydrate + thorium(IV) nitrate hydrate + periodic acid (10450-60-9) → Th(4+)*2IO3(1-)*CrO4(2-)=Th(IO3)2(CrO4)

Conditions	Yield
In water High Pressure; loading of Th(NO3)4*nH2O (0.435 mmol), H5IO6 (0.451 mmol), Cr(NO3)3*9H2O(0.451 mmol) and water in PTFE-lined autoclave; sealing, placing in pre heated furnace for 3 d at 2o0°C; cooling at 9°C/h to 23°C; crystn., washing with MeOH and drying;	99%

erbium + periodic acid (10450-60-9) → erbium(III) iodate

Conditions	Yield
In water High Pressure; Er and H5IO6 mixed with H2O, placed in vessel, heated at 180°C for 70 h, cooled to 20°C;	99%

gadolinium + periodic acid (10450-60-9) → gadolinium(III) iodate

Conditions	Yield
In water High Pressure; Gd and H5IO6 mixed with H2O, placed in vessel, heated at 180°C for 70 h, cooled to 20°C;	99%

Tl(3+)*3ClO4(1-)*6H2O=Tl(ClO4)3*6H2O + periodic acid (10450-60-9) → thallium(III) periodate

Conditions	Yield
In perchloric acid mixed, stirred (30 min); filtered, washed (dilute HClO4, H2O), dried (40°C in air); elem.anal.;	98%

potassium fluoride + hydrogen fluoride (7664-39-3) + bismuth(III) oxide (1304-76-3) + periodic acid (10450-60-9) → KBi2(IO3)2F5

Conditions	Yield
In water at 210℃; for 96h;	97%

Upstream product

• 7697-37-2 nitric acid 
• 7782-68-5 iodic acid 
• 7790-28-5 sodium periodate 
• 7664-41-7 ammonia 

Downstream Products

• 25402-50-0 (IO₂F₃)2 
• 151721-79-8 1,3,5-trichloro-2,4,6-triiodo-benzene 
• 7553-56-2 iodine 
• 5408-56-0 2-iododibenzofuran 
• 13446-76-9 rubidium iodate 
• 7803-68-1 orhtotelluric acid 
• 7790-38-7 palladium(II) iodide 
• 12029-98-0 iodine pentoxide 
• 13444-71-8 periodic acid 
• 7782-68-5 iodic acid 
• 7664-93-9 sulfuric acid 
• 7704-34-9 sulfur 
• 7790-99-0 Iodine monochloride 
• 7732-18-5 water 

Relevant articles and documents

Complexing between orthoperiodic acid and periodate ion in nitric acid solutions

Preparative synthesis techniques have been developed for four complex salts (Rb[H4IO6 ? H5IO6], Cs[H 4IO6 ? H5IO6], Cs[H 4IO6 ? H5IOs