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L-Homophenylalanine hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 105382-09-0 Structure
  • Basic information

    1. Product Name: L-Homophenylalanine hydrochloride
    2. Synonyms: (S)-2-AMINO-4-PHENYLBUTYRIC ACID HYDROCHLORIDE;L-HOMOPHENYLALANINE HCL;L-HOMOPHENYLALANINE HCL SALT;L-HOMOPHENYLALANINE HYDROCHLORIDE;L-HOMOPHENYLALANINE HYDROCHLORIDE SALT;LHPA HCL SALT;HOMOPHENYLALANINE HYDROCHLORIDE;H-HOPHE-OH HCL
    3. CAS NO:105382-09-0
    4. Molecular Formula: C10H14ClNO2
    5. Molecular Weight: 215.68
    6. EINECS: N/A
    7. Product Categories: Amino hydrochloride
    8. Mol File: 105382-09-0.mol
  • Chemical Properties

    1. Melting Point: 262-265 °C (dec.)(lit.)
    2. Boiling Point: 324.8 °C at 760 mmHg
    3. Flash Point: 150.2 °C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 9.79E-05mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Store at RT.
    9. Solubility: N/A
    10. CAS DataBase Reference: L-Homophenylalanine hydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: L-Homophenylalanine hydrochloride(105382-09-0)
    12. EPA Substance Registry System: L-Homophenylalanine hydrochloride(105382-09-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 105382-09-0(Hazardous Substances Data)

105382-09-0 Usage

Chemical Properties

White powder

Uses

L-Homophenylalanine, HCl

Check Digit Verification of cas no

The CAS Registry Mumber 105382-09-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,8 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105382-09:
(8*1)+(7*0)+(6*5)+(5*3)+(4*8)+(3*2)+(2*0)+(1*9)=100
100 % 10 = 0
So 105382-09-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO2.ClH/c11-9(10(12)13)7-6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H,12,13);1H/t9-;/m0./s1

105382-09-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name L-Homophenylalanine hydrochloride

1.2 Other means of identification

Product number -
Other names L-HOMOPHENYLALANINE HYDROCHLORIDE SALT

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105382-09-0 SDS

105382-09-0Relevant articles and documents

An efficient asymmetric biomimetic transamination of α-keto esters to chiral α-amino esters

Xiao, Xiao,Liu, Mao,Rong, Chao,Xue, Fazhen,Li, Songlei,Xie, Ying,Shi, Yian

, p. 5270 - 5273 (2013/01/15)

An efficient asymmetric biomimetic transamination of α-keto esters with quinine derivatives as chiral bases was described. A wide variety of α-amino esters containing various functional groups can be synthesized in high yield and enantioselectivity.

New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R)

Pavan, Michela V.,Lassiani, Lucia,Berti, Federico,Stefancich, Giorgio,Ciogli, Alessia,Gasparrini, Francesco,Mennuni, Laura,Ferrari, Flora,Escrieut, Chantal,Marco, Esther,Makovec, Francesco,Fourmy, Daniel,Varnavas, Antonio

experimental part, p. 5769 - 5785 (2011/10/09)

The anthranilic acid diamides represent the most recent class of nonpeptide CCK1 receptor (CCK1-R) antagonists. Herein we describe the second phase of the anthranilic acid C-terminal optimization using nonproteinogenic amino acids containing a phenyl ring in their side chain. The Homo-Phe derivative 2 (VL-0797) enhanced 12-fold the affinity for the rat CCK1-R affinity and 15-fold for the human CCK1-R relative to the reference compound 12 (VL-0395). The eutomer of 2 (6) exhibited a nanomolar range affinity toward the human CCK1-R and was at least 400-fold selective for the CCK1-R over the CCK2-R. Molecular docking in the modeled CCK1-R and its validation by site-directed mutagenesis experiments showed that the 6 binding site overlaps that occupied by the C-terminal bioactive region of the natural agonist CCK. Owing to their interesting properties, new compounds provided by this study represent a solid basis for further advances aimed at synthesis of clinically valuable CCK1-R antagonists.

Asymmetric and efficient synthesis of homophenylalanine derivatives via Friedel-Crafts reaction with trifluoromethanesulfonic acid

Murashige, Ryo,Hayashi, Yuka,Hashimoto, Makoto

supporting information; scheme or table, p. 6566 - 6568 (2009/04/05)

An efficient Friedel-Crafts reaction of TFA-Asp(Cl)-OMe and stoichiometric amounts of benzene was established by using neat trifluoromethanesulfonic acid (TfOH) as solvent and catalyst under a mild condition. This methodology has been applied to many arom

Asymmetric petasis reactions catalyzed by chiral biphenols

Lou, Sha,Schaus, Scott E.

, p. 6922 - 6923 (2008/09/21)

Chiral biphenols catalyze the enantioselective Petasis reaction of alkenyl boronates, secondary amines, and ethyl glyoxylate. The reaction requires the use of 15 mol % of (S)-VAPOL as the catalyst, alkenyl boronates as nucleophiles, ethyl glyoxylate as the aldehyde component, and 3 A molecular sieves as an additive. The chiral α-amino ester products are obtained in good yields (71-92%) and high enantiomeric ratios (89:11-98:2). Mechanistic investigations indicate single ligand exchange of acyclic boronate with VAPOL and tetracoordinate boronate intermediates. Copyright

Total synthesis of amiclenomycin, an inhibitor of biotin biosynthesis.

Mann, Stephane,Carillon, Sophie,Breyne, Olivier,Marquet, Andree

, p. 439 - 450 (2007/10/03)

We describe the first synthesis of amiclenomycin, a natural product that has been found to inhibit biotin biosynthesis and, as a consequence, to exhibit antibiotic properties. Structure 1, with a trans relationship between the ring substituents. had previously been proposed for amiclenomycin on the basis of its 1H NMR spectrum. We have prepared the trans and cis isomers 1 and 2 by unequivocal routes and we conclude that the natural product is in fact the cis isomer 2. The properly substituted cyclohexadienyl rings were constructed first. A cycloaddition reaction between 1,2-di(phenylsulfonyl)ethylene and the N-allyloxycarbonyl diene 13, followed by reductive elimination of the phenylsulfinyl groups, gave the cis isomer 15. To obtain the trans isomer, the O-trimethylsilyl diene was used to give the cis hydroxylated Diels-Alder adduct 33, which was transformed into the corresponding trans amino derivative by means of a Mitsunobu reaction. The L-alpha-amino acid functionality was introduced by means of a Strecker reaction on the aldehydes 16 and 42, followed by enzymatic hydrolysis with immobilised pronase.

Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

Zhao, Hua,Luo, Robert G.,Wei, Dean,Malhotra, Sanjay V.

, p. 1 - 3 (2007/10/03)

The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other

The synthesis of L-(+)-homophenylalanine hydrochloride

Xu, Qianyong,Wang, Guoxin,Wang, Xuechao,Wu, Tongxing,Pan, Xinfu,Chan, Albert S.C.,Yang, Teng-Kuei

, p. 2309 - 2314 (2007/10/03)

L-(+)-Homophenylalanine hydrochloride was synthesized from N-phthaloyl-L-(-)-asparitc anhydride 2 in three steps in 55% overall yield with 99% ee. Copyright (C) 2000 Elsevier Science Ltd.

Asymmetric amino acid synthesis: Mitsunobu reaction on chiral cyanohydrins

Decicco, Carl P.,Grover, Paul

, p. 529 - 530 (2007/10/03)

BOC(SES)NH was reacted with chiral cyanohydrins using the Mitsunobu reaction to give good yields of protected α-aminonitriles, which were converted to chiral amino and imino acids.

Hexa- and heptapeptide anaphylatoxin-receptor ligands

-

, (2008/06/13)

Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.Also disclosed are anaphylatoxin receptor ligand compositi

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