106928-72-7

Basic information

• Product Name: TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE;(1S,9S)-9-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)octahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester
• CAS NO: 106928-72-7
• Molecular Formula: C₂₂H₂₅N₃O₆
• Molecular Weight: 427.45
• Mol File: 106928-72-7.mol

Chemical Properties

• Appearance: /
• Density: 1.39
• CAS DataBase Reference: TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE(106928-72-7)
• EPA Substance Registry System: TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE(106928-72-7)

Safety Data

• Hazardous Substances Data: 106928-72-7(Hazardous Substances Data)

Upstream product

• 88784-33-2 (2S)-4-benzyloxicarbonyl-2-phthalimidobutanoic acid 
• 65632-62-4 (3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester 
• 156699-38-6 (4S)-3-<(3S)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone 
• 156699-39-7 (3S)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid 
• 156699-37-5 (S)-4-benzyl-3-(5-bromopentanoyl)oxazolidine-2-one 
• 72064-51-8 (3S)-N¹-benzyloxycarbonyl-piperazic acid tert-butyl ester 
• 106860-13-3 (S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 88767-16-2 (S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 4509-90-4 5-bromovaleroyl chloride 
• 88767-18-4 (S,S)-5-(6-(tert-butoxycarbonyl)tetrahydropyridazin-1(2H)-yl)-4-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid 

Downstream Products

• 106927-97-3 (1S,9S)-t-butyl octahydro-10-oxo-9-phthalimido-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 625415-56-7 (1S,9S)-9-(benzylidene-amino)-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester 
• 192753-57-4 (1S,9S)-9-Benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 
• 192753-53-0 9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester 
• 192755-43-4 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester 
• 234752-71-7 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-N-methoxy-N-methyl-succinamic acid tert-butyl ester 
• 88768-40-5 cilazapril 
• 106860-20-2 9-amino-octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-(S)carboxylic acid t-butyl ester 
• 106860-19-9 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-10-oxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88767-97-9 (1S,9S)-t-butyl 9-<(1R)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88824-62-8 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 1399845-58-9 methyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate 
• 1399845-59-0 methyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate 
• 1399845-60-3 methyl (4S,7S)-6,10-dioxo-4-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)octahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF CILAZAPRIL

The present invention relates to a process for the preparation of optically pure (S,S)-6-t-butoxycarbonyl-hexahydro-1-pyridazinylcarbonyl-1,3-dioxo-2-isoindolebutyric acid, an intermediate for the preparation of cilazapril.

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9- (benzoylamino)octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1- yl]-carbonyl]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

The title compound 1 is a potent interleukin-1β-converting enzyme (ICE) inhibitor. Recently, an efficient chiral synthesis of compound 1 has been accomplished in our labs. The overall yield of this 18-step stereoselective synthesis was 9.8%.

The Design and Synthesis of the Angiotensin Converting Enzyme Inhibitor Cilazapril and Related Bicyclic Compounds

The postulated binding functions for the active site of Angiotensin Converting Enzyme (A.C.E.), derived in an earlier study, have made possible the design of improved inhibitors.Consequently, (1S,9S)-9-octahydro-10-oxo-6H-pyridazodiazepine-1-carboxylic acid (Cilazapril), and related compounds, have been synthesized.They are very active inhibitors of A.C.E. and are highly potent antihypertensives in vivo.