108321-66-0Relevant articles and documents
Reactions of perfluoroalkanesulfonyl chlorides with silyl enol ethers catalyzed by a ruthenium(II) phosphine complex
Kamigata, Nobumasa,Udodaira, Kumiko,Shimizu, Toshio
, p. 155 - 168 (1997)
Reactions of trifluoromethane- and tridecafluorohexanesulfonyl chlorides with silyl enol ethers have been investigated in the presence of a ruthenium(II) phosphine complex. Perfluoroalkylation and chlorination occurred depending on the substituent of silyl enol ether; i.e. perfluoroalkylated compound was selectively obtained in the reactions with silyl enol ether possessing an electron-withdrawing group, on the other hand, chlorinated compounds selectively formed in the reaction with a silyl enol ether possessing electron-donating group.
Reactions of alkynylselenonium salts with tetrabutylammonium halides: Apparent umpolung of alkynyl moiety
Kataoka, Tadashi,Watanabe, Shin-ichi,Yamamoto, Keiichirou
, p. 931 - 934 (1999)
The reactions of alkynylselenonium salts with n-Bu4NX (X = I, Br, Cl) in CH2Cl2 gave 1-halo-1-alkynes or phenacyl halide derivatives and selenide, while the reaction with F afforded a terminal alkyne and a selenoxide. Seemingly, the selenonium salts acted as alkynyl cations in the former case and as alkynyl anions in the latter case.
New, efficient synthesis of α-chloroketones using SiCl 4/urea-hydrogen peroxide or SiCl4/iodosylbenzene reagent systems
El-Ahl, Abdel Aziz S.,Elbeheery, Akram H.,Amer, Fathy A.
, p. 1508 - 1513 (2011)
Alkyl aryl ketones on treatment with SiCl4/urea-hydrogen peroxide (UHP) or SiCl4/iodosylbenzne reagent systems afforded -chloroketones in excllent yields, while ketones with higher enol content provide exclusively,-dichloroketones under exceedingly mild conditions. The reaction proceeds via the initial formation of silyl enol ethers. A polarized chlorine intermediate that resulted from the coordination of SiCl4 with the in situ formed trichlorosilyl hypochlorite Cl3SiOCl is thought to be the active chlorinating agent.
Design, synthesis, & biological activity of new triazole & nitro-triazole derivatives as antifungal agents
Sadeghpour, Hossein,Khabnadideh, Soghra,Zomorodian, Kamiar,Pakshir, Keyvan,Hoseinpour, Khadijeh,Javid, Nabiollah,Faghih-Mirzaei, Ehsan,Rezaei, Zahra
, (2017)
In this study two series of fluconazole derivatives bearing nitrotriazole (series A) or piperazine ethanol (series B) side chain were designed and synthesized and then docked in the active site of lanosterol 14α-demethylase enzyme (1EA1) using the Autodock 4.2 program (The scripps research institute, La Jolla, CA, USA). The structures of synthesized compound were confirmed by various methods including elemental and spectral (NMR, CHN, and Mass) analyses. Then antifungal activities of the synthesized compound were tested against several natural and clinical strains of fungi using a broth microdilution assay against several standard and clinical fungi. Nitrotriazole derivatives showed excellent and desirable antifungal activity against most of the tested fungi. Among the synthesized compounds, 5a-d and 5g, possessing nitrotriazole moiety, showed maximum antifungal activity, in particular against several fluconazole-resistant fungi.
MONOHALOMETHYLLITHIUM XCH2Li : STABILIZATION OF A POTENTIAL SYNTHETIC REAGENT
Tarhouni, R.,Kirschleger, B.,Rambaud, M.,Villieras, J.
, p. 835 - 838 (1984)
The preparation of monohalomethyllithium XCH2Li is achieved by Bromine-lithium exchange from the corresponding Bromohalomethane in the presence of one equivalent of lithium bromide at -110 degC in THF-Ether-Pentane solutions.This reagent, on coupling with various carbonyl compounds leads to halohydrins, epoxides and α-halomethyl ketones with high yields.
AgF/TFA-promoted highly efficient synthesis of α-haloketones from haloalkynes
Chen, Zheng-Wang,Ye, Dong-Nai,Ye, Min,Zhou, Zhong-Gao,Li, Shen-Huan,Liu, Liang-Xian
, p. 1373 - 1375 (2014)
A AgF/TFA-promoted highly efficient synthesis of a wide range of α-haloketones from haloalkynes is described. The reactions are conducted under convenient conditions and provide products in moderate to excellent yields, with broad substrate scope, including a variety of aromatic chloroalkynes and bromoalkynes.
α-chlorination of acetophenones using 1,3-dichloro-5,5- dimethylhydantoin
Xu, Zijin,Zhang, Deyan,Zou, Xinzhuo
, p. 255 - 258 (2006)
A novel method for the synthesis of α-chloroacetophenones using 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) and p-toluenesulfonic acid in methanol at 30-35°C is described. Substituted acetophenones at the para position or meta position of aromatic ring give α-chloroacetophenones in high yield. However, reaction of o-nitroacetophenone does not take place under the same condition. Copyright Taylor & Francis LLC.
Indium(I) bromide-mediated reductive coupling of α,α- dichloroketones to 1-aryl-butane-1,4-diones
Peppe, Clovis,Pav?o Das Chagas, Rafael
, p. 1187 - 1190 (2004)
Indium(I) bromide promotes the reductive coupling of α,α- dichloroketones to the corresponding 1,4-butanediones in moderate to good yields.
Water-controlled selective preparation of α-mono or α,α′-dihalo ketones: Via catalytic cascade reaction of unactivated alkynes with 1,3-dihalo-5,5-dimethylhydantoin
Wu, Chao,Xin, Xiu,Fu, Zhi-Min,Xie, Long-Yong,Liu, Kai-Jian,Wang, Zheng,Li, Wenyi,Yuan, Zhi-Hui,He, Wei-Min
, p. 1983 - 1989 (2017)
The control of a reaction that can produce multiple products from the same starting material is a highly attractive and challenging concept in organic synthesis. An efficient protocol for the selective synthesis of α-mono or α,α′-dihalo ketones via a water-controlled three-component thiourea-catalyzed cascade reaction of unactivated alkynes, 1,3-dihalo-5,5-dimethylhydantoin and water has been developed. α-Monohaloketones were obtained in aqueous acetone at 45 °C; conversely, α,α′-dihalo ketones were formed with pure water as the sole solvent at room temperature.
Chlorination of Organic Compounds by Means of Polymer-supported Chlorine
Bongini, Alessandro,Cainelli, Gianfranco,Contento, Michele,Manescalchi, Francesco
, p. 1278 - 1279 (1980)
Chlorination of organic compounds is achieved, under mild conditions, using chlorine incorporated into an anion-exchange resin.
