1116-98-9Relevant articles and documents
Synthesis, photo-electrochemical properties and dye-sensitized solar cell performance of d-π-A structured porphyrins
Zhang, Hongxing,Zheng, Xiuwen,Li, Haiying,Jin, Bin,Wang, Chengyun,Shen, Yongjia,Hua, Jianli
, p. 58 - 64 (2013)
Two new dye sensitizers 5-(N,N-4-(diphenylamino)phenyl)-10-(4-(tert-butyl- 2-cyanoacrylate)phenyl)porphyrin (TP) and 5-(N, N-4-(bis(4-butylphenyl) amino) phenyl)-10-(4-(tert-butyl-2-cyanoacrylate)phenyl)porphyrin (BUTP) with cyanoacrylic acid as electron acceptor were synthesized and researched. BUTP has strong absorption in a wide range of 300-726 nm. DSSCs sensitized by BUTP displayed a power conversion efficiency (η) 5.33%, JSC 12.21 mA cm-2, Voc 0.68 V, FF 0.65, under the illumination of AM 1.5 G. Spectral properties, electrochemical properties, photovoltaic and electrochemical impedance properties of TP and BUTP were also investigated. Considering its simple synthesis, both TP and BUTP were qualified sensitizers for DSSCs.
Continuous flow preparation method of tert-butyl cyanoacetate
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Paragraph 0027-0038, (2021/04/14)
The invention belongs to the technical field of organic chemistry, and particularly relates to a continuous flow preparation method of tert-butyl cyanoacetate. A substrate solution containing cyanoacetic acid and Lewis acid and isobutene are simultaneously conveyed into a micro-reaction system comprising a micro-mixer and a micro-channel reactor which are sequentially communicated, and a continuous catalytic esterification reaction is performed to obtain tert-butyl cyanoacetate. Compared with the traditional batch kettle type synthesis method, the continuous flow preparation method has the advantages of short reaction time, high product yield, high automation degree, high process continuous efficiency, high space-time yield, low energy consumption and easiness in industrial amplification, and is easy for industrial application.
Synthesis method of tert-butyl cyanoacetate
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Paragraph 0021-0035, (2021/04/14)
The invention belongs to the technical field of organic chemistry, and particularly relates to a synthesis method of tert-butyl cyanoacetate. Cyanoacetic acid and isobutene are subjected to a catalytic esterification reaction in an organic solvent in the presence of Lewis acid to obtain tert-butyl cyanoacetate. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple operation, simple post-treatment, low cost, high product yield and high product purity, and is easy for industrial production.
Magnetically recoverable AlFe/Te nanocomposite as a new catalyst for the facile esterification reaction under neat conditions
Alavi, Seyed Jamal,Sadeghian, Hamid,Seyedi, Seyed Mohammad,Eshghi, Hossein,Salimi, Alireza
, (2017/11/23)
In this work, a new Fe3O4/AlFe/Te nanocomposite was synthesized by a one-step sol–gel method. The Fe3O4 magnetic nanoparticles (MNPs) were prepared and then mixed with aluminum telluride (Al2Te3) in an alkali medium to produce the desired catalyst. After characterization of the Fe3O4/AlFe/Te nanocomposite by SEM, TEM, EDS, XRD, and ICP analyses, it was used in the esterification reaction. This heterogeneous catalyst showed high catalytic activity in the esterification of commercially available carboxylic acids with various alcohols to produce the desired esters at high conversions under neat conditions. The Fe3O4/AlFe/Te nanocomposites were separated from the reaction mixture via an external magnet and re-used 8 times without significant loss of catalytic activity.
Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity
Vivier, Delphine,Soussia, Ismail Ben,Rodrigues, Nuno,Lolignier, Stéphane,Devilliers, Ma?ly,Chatelain, Franck C.,Prival, Laetitia,Chapuy, Eric,Bourdier, Geoffrey,Bennis, Khalil,Lesage, Florian,Eschalier, Alain,Busserolles, Jér?me,Ducki, Sylvie
, p. 1076 - 1088 (2017/02/19)
The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we report the synthesis of a series of substituted acrylic acids (1-54) based on our previous work with caffeate esters. The analogues were evaluated for their ability to modulate TREK-1 channel by electrophysiology and for their in vivo antinociceptive activity (acetic acid-induced writhing and hot plate assays), leading to the identification of a series of novel molecules able to activate TREK-1 and displaying potent antinociceptive activity in vivo. Furyl analogue 36 is the most promising of the series.
HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
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Page/Page column 182; 183; 184, (2016/10/08)
The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
PAIN RELIEF COMPOUNDS
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Paragraph 0500-0501, (2015/02/19)
The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.
Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel
Rodrigues, Nuno,Bennis, Khalil,Vivier, Delphine,Pereira, Vanessa,Chatelain, Franck C.,Chapuy, Eric,Deokar, Hemantkumar,Busserolles, Jér?me,Lesage, Florian,Eschalier, Alain,Ducki, Sylvie
supporting information, p. 391 - 402 (2014/03/21)
The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs. It has been reported that TREK-1 -/- mice were more sensitive than wild-type mice to painful stimuli, suggesting that activation of TREK-1 could result in pain inhibition. Here we report the synthesis of a series of substituted caffeate esters (12a-u) based on the hit compound CDC 2 (cinnamyl 3,4-dihydroxyl-α-cyanocinnamate). These analogs were evaluated for their ability to modulate TREK-1 channel by electrophysiology and for their in vivo antinociceptive activity (acetic acid induced-writhing assay) leading to the identification a series of novel molecules able to activate TREK-1 and displaying potent analgesic activity in vivo.
A practical system to synthesize the multiple-substituted 2,5-dihydrofuran by the intermolecular dipolar cycloaddition reactions involving acceptor/acceptor-substituted diazo reagents
Zhu, Shifa,Chen, Lijuan,Wang, Chao,Liang, Renxiao,Wang, Xiujun,Ren, Yanwei,Jiang, Huanfeng
experimental part, p. 5507 - 5515 (2011/08/06)
A practical system for synthesizing the multiple-substituted 2,5-dihydrofuran through intermolecular dipolar cycloaddition reactions of acceptor/acceptor diazo reagents, aldehydes, and acetylenedicarboxylate was developed. The reactions proceeded effectively under ambient temperature with low reactant ratios. The control reactions revealed that there are two competitive paths: one forms 1,3-dioxolane and the other forms 2,5-dihydrofuran. These two paths could be controlled by modifying the steric hindrance of the diazo reagents.
AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS
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Page/Page column 50, (2011/10/10)
Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).
