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2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride is a chemical compound that serves as a reagent in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a tetrahydropyrido[4,3-d]pyrimidine ring with two chlorine atoms at the 2nd and 4th positions, and a hydrochloride group.

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  • 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1:1)

    Cas No: 1208901-69-2

  • USD $ 1.9-2.9 / Gram

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  • 1208901-69-2 Structure
  • Basic information

    1. Product Name: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
    2. Synonyms: 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE HCL
    3. CAS NO:1208901-69-2
    4. Molecular Formula: C7H7Cl2N3*ClH
    5. Molecular Weight: 240.51752
    6. EINECS: N/A
    7. Product Categories: Heterocycle-Pyrimidine series
    8. Mol File: 1208901-69-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride(1208901-69-2)
    11. EPA Substance Registry System: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride(1208901-69-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1208901-69-2(Hazardous Substances Data)

1208901-69-2 Usage

Uses

Used in Pharmaceutical Industry:
2,4-dichloro-5,6,7,8-tetrahydropyrimidine hydrochloride is used as a reagent for the preparation of fused aminopyrimidines. These fused aminopyrimidines act as glucose uptake inhibitors, which are essential in the treatment of parasitic and viral infections. The compound's role in the synthesis process is crucial, as it contributes to the development of effective therapeutic agents against these infections.

Check Digit Verification of cas no

The CAS Registry Mumber 1208901-69-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,9,0 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1208901-69:
(9*1)+(8*2)+(7*0)+(6*8)+(5*9)+(4*0)+(3*1)+(2*6)+(1*9)=142
142 % 10 = 2
So 1208901-69-2 is a valid CAS Registry Number.

1208901-69-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

1.2 Other means of identification

Product number -
Other names 2,4-Dichloro-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1208901-69-2 SDS

1208901-69-2Relevant articles and documents

TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS

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Paragraph 0337; 0338, (2017/01/09)

Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity

Koehler, Michael F. T.,Bergeron, Philippe,Blackwood, Elizabeth,Bowman, Krista K.,Chen, Yung-Hsiang,Deshmukh, Gauri,Ding, Xiao,Epler, Jennifer,Lau, Kevin,Lee, Leslie,Liu, Lichuan,Ly, Cuong,Malek, Shiva,Nonomiya, Jim,Oeh, Jason,Ortwine, Daniel F.,Sampath, Deepak,Sideris, Steve,Trinh, Lan,Truong, Tom,Wu, Jiansheng,Pei, Zhonghua,Lyssikatos, Joseph P.

, p. 10958 - 10971 (2013/02/25)

Selective inhibitors of mammalian target of rapamycin (mTOR) kinase based upon saturated heterocycles fused to a pyrimidine core were designed and synthesized. Each series produced compounds with Ki 500-fold sel

BICYCLIC PYRIMIDINE DERIVATIVES

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, (2008/06/13)

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m + n is 4 or less; R1 represents NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, -C(=O)-, -SO2-, -OC(=O)- or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]ψBicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH

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, (2010/02/12)

The present invention provides an agent for prevention and/or treatment of itching comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents substituted or unsubstituted lower alkyl, etc.; R2 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, etc.; n represents 0 or 1; X represents -(CH2)2-, etc.; and Y represents the formula (II); (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, substituted or unsubstituted lower alkyl, etc.; and Z3 represents hydrogen, substituted or unsubstituted lower alkyl, etc.)]

PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA

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Page/Page column 61-62, (2010/02/11)

The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides an agent for prevention and/or treatment of asthma which comprises a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents a substituted or unsubstituted lower alkyl, or the like; R2 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, or the like; n represents 0 or 1; X represents -(CH2)2-, or the like; and Y represents the formula (II) (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; and Z3 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like)] as an active ingredient.

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