141113-36-2

Basic information

• Product Name: 2-(2,4-Difluorophenyl)-2-propen-1-ol
• Synonyms: 2-(2,4-Difluorophenyl)-2-propen-1-ol;2,4-Difluoro-β-Methylene-benzeneethanol
• CAS NO: 141113-36-2
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.1560264
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 141113-36-2.mol

Chemical Properties

• Boiling Point: 229℃
• Flash Point: 92℃
• Appearance: /
• Density: 1.205
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
• PKA: 14.07±0.10(Predicted)
• CAS DataBase Reference: 2-(2,4-Difluorophenyl)-2-propen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Difluorophenyl)-2-propen-1-ol(141113-36-2)
• EPA Substance Registry System: 2-(2,4-Difluorophenyl)-2-propen-1-ol(141113-36-2)

Safety Data

• Hazardous Substances Data: 141113-36-2(Hazardous Substances Data)

Usage

Uses

Intermediate in the preparation of antifungal agents.

Upstream product

• 149809-34-7 1-[2-(2,4-Difluorophenyl)]-2-propenol Acetate 
• 60-29-7 diethyl ether 
• 7440-44-0 pyrographite 
• 348-57-2 2,4-difluorobromobenzene 
• 164347-62-0 1,2-epoxy-3-chloro-2-(2,4-difluorophenyl)-propane 
• 86386-74-5 1,3-(dichloro)-2-(2,4-difluorophenyl)propan-2-ol 

Downstream Products

• 159276-58-1 1-(1-Bromomethyl-vinyl)-2,4-difluoro-benzene 
• 141113-39-5 (S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol 
• 141113-37-3 (S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol 
• 149882-16-6 (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 141113-42-0 (S)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole 
• 141113-41-9 (R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol 
• 165115-73-1 2-[2-(2,4-difluorophenyl)-2-propene-1-yl]-1, 3-propanediol 
• 159276-62-7 diethyl 2-[2-(2,4-difluorophenyl)-2-propen-1-yl]-1,3-propanedioate 
• 156570-10-4 1-(1-chloromethylethenyl)-2,4-difluorobenzene 
• 182009-45-6 (R)-4-benzyl-3-((S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-enoyl)oxazolidin-2-one 
• 165115-74-2 (R)-4-benzyl-3-(4-(2,4-difluorophenyl)pent-4-enoyl)oxazolidin-2-one 
• 165115-70-8 4-(2,4-difluorophenyl)-pent-4-enoic acid 

Relevant articles and documents

Asymmetric synthesis, antifungal activity and molecular modeling of iodiconazole isomers

Iodiconazole is a novel antifungal agent that was developed in its racemic form. In order to investigate the effects of the chiral center on the antifungal activity, R- and S-isomers of iodiconazole were prepared on the basis of the asymmetric Sharpless epoxidation. (S)-Iodiconazole was proved to have better antifungal activity than the (R)-isomer. The binding modes of the two isomers with lanosterol 14α-demethylase were clarified by molecular docking. Two isomers of iodiconazole, a novel antifungal agent, were prepared by asymmetric synthesis. Their antifungal activity and binding modes were investigated. Copyright

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two groups convertible in vivo into hydroxy moieties, (e.g., a polyether ester, amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two amino acid ester groups (e.g., an amino acid ester group convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two polyetyher ester groups (e.g., a polyether ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Hydroxy-substituted antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester, heterocyclic ester amino acid ester or phosphate ester) thereof and the carbon with the asterisk (*) has the R or S absolute configuration or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two phosphate ester groups (e.g., a phosphate ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether ester (e.g., a polyetherester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Tri-substituted tetrahydrofuran antifungals

An antifungal compound represented by formula [I]: wherein X is independently both F or both Cl or one X is F and the other is Cl; Y=R'= (C1-C10) alkyl; (C2-C10)alkenyl; (C2-C10)alkynyl; (C3-C8)cycloalky or CH2R2; R2= (C1-C3)perhaloalkyl; CO2R3 *CH(OR4)CH2OR4 or CH2N(R5) R3= lower alkyl or H R4= R3 or (CH2)2OR3 R5= lower alkyl Z=H, or (C1-C5) alkanoyl and the carbons with the asterisks (*) have the R or S absolute configuration; or a pharmaceutically acceptable salt thereof as well as pharmacetical compositions containing them and a methods of treating or preventing fungal infections in mammals using them are disclosed.