17431-97-9

Basic information

• Product Name: AKOS B013937
• Synonyms: 2-Methyl-2-(4-nitrophenoxy)propanoic acid;2-methyl-2-(4-nitrophenoxy)propanoic acid(SALTDATA: FREE);Propanoic acid, 2-Methyl-2-(4-nitrophenoxy)-;CHEMBRDG-BB 3013937;ART-CHEM-BB B013937;AKOS B013937
• CAS NO: 17431-97-9
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.2
• Mol File: 17431-97-9.mol

Chemical Properties

• Boiling Point: 394.3°Cat760mmHg
• Flash Point: 192.3°C
• Appearance: /
• Density: 1.328g/cm³
• Vapor Pressure: 6.34E-07mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AKOS B013937(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS B013937(17431-97-9)
• EPA Substance Registry System: AKOS B013937(17431-97-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 17431-97-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO5/c1-10(2,9(12)13)16-8-5-3-7(4-6-8)11(14)15/h3-6H,1-2H3,(H,12,13)

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 100-02-7 4-nitro-phenol 
• 824-78-2 4-nitrophenol sodium salt 
• 540-38-5 p-Iodophenol 
• 67-66-3 chloroform 
• 67-64-1 acetone 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 7472-69-7 2-(4-bromophenoxy)-2-methylpropanoic acid 
• 37404-23-2 2-(4-iodophenoxy)-2-methylpropanoic acid 
• 23501-39-5 ethyl 2‐methyl‐2‐(4‐nitrophenoxy)propanoate 

Downstream Products

• 23501-39-5 ethyl 2‐methyl‐2‐(4‐nitrophenoxy)propanoate 
• 28048-87-5 ethyl 2-(4-aminophenoxy)-2-methylpropionate 
• 62100-54-3 2-hydroxy-4'-nitroisobutyranilide 
• 17413-84-2 2-(4-acetaminophenoxy)-2-methylpropionic acid 
• 62100-50-9 2,N-Dimethyl-2-(4-nitro-phenoxy)-propionamide 
• 62100-49-6 2-(4-Nitrophenyloxy)-2-methylpropionsaeureamid 
• 117011-70-8 2-(4-aminophenoxy)-2-methyl propionic acid 

Relevant articles and documents

Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives

Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study

Four isobutyric acids (two nitro and two acetamido derivatives) were prepared in two steps and characterized using spectral analysis. The mRNA concentrations of PPARγ and GLUT-4 (two proteins documented as key diabetes targets) were increased by 3T3-L1 ad

ipso Nitration in p-halophenyl ethers

Addition of nitronium ion ipso to halogen occurs on nitration of the p-haloanisoles in acetic anhydride at -60 deg C.In the cases of p-fluoro- and p-chloro-anisole, addition of the nitronium ion is reversible and only small amounts of ipso products are obtained.With p-bromoanisole nitrodebromination occurs.When p-halophenyl ethers containing a trapping substituent, e.g., 2-(4-chlorophenoxy)-2-methylpropanoic acid, are used as substrates, substantial amounts of the spiro diene with nitro ipso to halogen, e.g., 3,3-dimethyl-8-chloro-8-nitro-1,4-dioxaspirodeca-6,9-dien-2-one, can be isolated.The results demonstrate that extensive ipso attack at the halogen-substituted position is general in the nitration of p-halophenyl ethers.Key words: ipso nitration, ether, diene, p-haloanisole.