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(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine is a specialty chemical compound that belongs to the family of Pyrrolidines. It is primarily used in scientific research facilities. The term "Boc" in its name indicates the presence of a 'tert-butoxycarbonyl' protecting group, which is crucial for safeguarding the reactive amino and hydroxy groups during chemical reactions. (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine, with its specific stereochemistry of 3S,4S, holds potential for applications in the pharmaceutical industry. For detailed physical properties and safety information, it is essential to refer to its Material Safety Data Sheet (MSDS).

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  • 190792-74-6 Structure
  • Basic information

    1. Product Name: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine
    2. Synonyms: (3s,4s)-n-boc-3-amino-4-hydroxypyrrolidine;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3S,4S)-(9CI);(3S,4S)-3-Amino-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester;(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate;1-Boc-(3S,4S)-3-aMino-4-hydroxypyrrolidine;(3S,4S)-4-aMino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine;Trans-(3S,4S)-1-Boc-3-aMino-4-hydroxypyrrolidine;tert-butyl (3S,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate
    3. CAS NO:190792-74-6
    4. Molecular Formula: C9H18N2O3
    5. Molecular Weight: 202.25
    6. EINECS: N/A
    7. Product Categories: AMINOACID
    8. Mol File: 190792-74-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 308.762 °C at 760 mmHg
    3. Flash Point: 140.535 °C
    4. Appearance: /
    5. Density: 1.179
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 14.36±0.40(Predicted)
    10. CAS DataBase Reference: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine(190792-74-6)
    12. EPA Substance Registry System: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine(190792-74-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 190792-74-6(Hazardous Substances Data)

190792-74-6 Usage

Uses

Used in Pharmaceutical Development:
(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine is used as an intermediate compound in the synthesis of various pharmaceuticals. Its unique stereochemistry and the presence of the Boc protecting group make it a valuable building block for the development of new drugs.
Used in Scientific Research:
In the field of scientific research, (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine serves as a key compound for studying the properties and reactivity of Pyrrolidine derivatives. Its use in research helps in understanding the potential applications and limitations of this class of compounds in various chemical and biological processes.
Used in Chemical Synthesis:
(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine is used as a protected amino alcohol in the synthesis of complex organic molecules. The Boc protecting group allows for selective reactions to occur at other sites on the molecule, while the amino and hydroxy groups remain protected from unwanted side reactions. This makes it a useful tool in the synthesis of a wide range of chemical products.

Check Digit Verification of cas no

The CAS Registry Mumber 190792-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,7,9 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 190792-74:
(8*1)+(7*9)+(6*0)+(5*7)+(4*9)+(3*2)+(2*7)+(1*4)=166
166 % 10 = 6
So 190792-74-6 is a valid CAS Registry Number.

190792-74-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine

1.2 Other means of identification

Product number -
Other names H-STA-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:190792-74-6 SDS

190792-74-6Relevant articles and documents

N -phosphonocarbonylpyrrolidine derivatives of guanine: A new class of Bi-substrate inhibitors of human purine nucleoside phosphorylase

Rejman, Dominik,Panova, Natalya,Klener, Pavel,Maswabi, Bokang,Pohl, Radek,Rosenberg, Ivan

, p. 1612 - 1621 (2012/05/05)

A complete series of pyrrolidine nucleotides, (3R)- and (3S)-3-(guanin-9-yl)pyrrolidin-1-N-ylcarbonylphosphonic acids and (3S,4R)-, (3R,4S)-, (3S,4S)-, and (3R,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N- ylcarbonylphosphonic acids, were synthesized and e

Highly active organocatalysts for asymmetric anti-mannich reactions

Martín-Rapún, Rafael,Fan, Xinyuan,Sayalero, Sonia,Bahramnejad, Mahboubeh,Cuevas, Félix,Pericàs, Miquel A.

, p. 8780 - 8783 (2011/09/15)

Lighten the load! A family of enantiopure 4-oxy-substituted 3-aminopyrrolidines arising from the enantioselective ring-opening of meso-3-pyrroline oxide have been developed as catalysts for the asymmetric, anti-selective Mannich reaction (see scheme; PMP=

THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS

-

Page/Page column 40, (2010/01/12)

A series of thieno[2,3-6]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fus

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit

Zbinden, Katrin Groebke,Anselm, Lilli,Banner, David W.,Benz, Joerg,Blasco, Francesca,Decoret, Guillaume,Himber, Jacques,Kuhn, Bernd,Panday, Narendra,Ricklin, Fabienne,Risch, Philippe,Schlatter, Daniel,Stahl, Martin,Thomi, Stefan,Unger, Robert,Haap, Wolfgang

body text, p. 2787 - 2795 (2009/10/17)

Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.

MINERALOCORTICOID RECEPTOR ANTAGONISTS AND METHODS OF USE

-

Page/Page column 25, (2009/07/10)

The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Cyclic amines

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Page/Page column 36, (2010/11/24)

The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1′, R1″ and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.

Cathepsin cysteine protease inhibitors

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Page 18, (2010/02/06)

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Treatment of parasitic diseases by inhibition of cysteine proteases of the papain superfamily

-

, (2008/06/13)

The present invention relates to compounds and pharmaceutical compositions which inhibit proteases, such as cysteine proteases. In particular, the present invention relates to compounds and pharmaceutical compositions which inhibit cysteine proteases of the papain superfamily. The compounds and pharmaceutical compositions of the present invention are useful for treating diseases, particularly parasitic diseases, which are mediated by such proteases. In particular, the present invention relates to a method of treating malaria by inhibiting the cysteine protease falcipain.

Practical synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine

Tsuzuki, Yasunori,Chiba, Katsumi,Mizuno, Kazuhiro,Tomita, Kyoji,Suzuki, Kenji

, p. 2989 - 2997 (2007/10/03)

Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumur agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (±)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene.

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