20193-20-8

Basic information

• Product Name: N-Ethylpropylamine
• Synonyms: N-ETHYLPROPYLAMINE;1-propanamine,N-ethyl;1-Propanamine,N-ethyl-;Ethylpropylamine;ethyl-propyl-amine;N,N-Ethylpropylamine;n-ethyl-1-propanamin;N-Ethyl-1-propanamine
• CAS NO: 20193-20-8
• Molecular Formula: C₅H₁₃N
• Molecular Weight: 87.16
• EINECS: 243-573-4
• Product Categories: Amines and Anilines;Polyamines
• Mol File: 20193-20-8.mol

Chemical Properties

• Melting Point: -75°C (estimate)
• Boiling Point: 80-85°C
• Flash Point: 80-85°C
• Appearance: /Liquid
• Density: 0,72 g/cm3
• Vapor Pressure: 185mmHg at 25°C
• Refractive Index: 1.3950-1.3980
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate
• PKA: 10.76±0.19(Predicted)
• CAS DataBase Reference: N-Ethylpropylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethylpropylamine(20193-20-8)
• EPA Substance Registry System: N-Ethylpropylamine(20193-20-8)

Safety Data

• Hazard Codes: F,T,C
• Statements: 34-11-37-35-24-20/22
• Safety Statements: 26-36/37/39-45-20
• RIDADR: 2735
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 20193-20-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Ethylpropylamine is used as a synthetic intermediate for the production of neuraminidase inhibitors, which are important antiviral agents used to treat influenza infections. It is also used in the synthesis of non-peptide CRF-1 antagonists, which have potential applications in the treatment of stress-related disorders and anxiety.

Flammability and Explosibility

Highlyflammable

InChI:InChI=1/C5H13N/c1-3-5-6-4-2/h6H,3-5H2,1-2H3/p+1

Upstream product

• 5339-67-3 N-ethylbenzenesulfonamide 
• 107-08-4 1-iodo-propane 
• 1946-09-4 diethyl N-ethylphosphoramidate 
• 106-94-5 propyl bromide 
• 20577-33-7 ethylidene-propyl-amine 
• 5331-48-6 n-propylacetamide 
• 5129-72-6 N-ethylpropionamide 
• 71-23-8 propan-1-ol 
• 75-04-7 ethylamine 
• 40548-47-8 N-ethyl-N-propyl-hydroxylamine 
• 7664-93-9 sulfuric acid 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 123-38-6 propionaldehyde 

Downstream Products

• 6288-97-7 ethyl-propyl-(1⁽²⁾H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine 
• 778592-09-9 N-ethyl-N-propyl-benzenesulfonamide 
• 4682-26-2 2-(Ethyl-propyl-amino)-1-phenyl-propan-1-one 
• 64122-74-3 (1-ethylpropyl)-3-(methoxymethyl)-4-methyl-2,6-dinitroaniline 
• 1638-86-4 diethyl phenylphosphonite 
• 1029437-27-1 [4-[[ethyl(propyl)amino]methyl]phenyl]methanol 
• 25413-61-0 ethyl-nitroso-propyl-amine 
• 148807-79-8 N-benzyl-N-ethylpropan-1-amine 
• 1218904-24-5 2-{5-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-3-yl}-N-(3-fluorophenyl)acetamide 
• 1519060-43-5 3-{[(16β,17β)-3-[(ethyl(propyl)amino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide 

Relevant articles and documents

PROCESS FOR PREPARING AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION IN THE PRESENCE OF A COMPLEX CATALYST COMPRISING IRIDIUM AND AN AMINO ACID

The invention relates to a process for preparing amines (A) by alcohol amination of alcohols (Al) by means of an aminating agent (Am) with elimination of water, wherein the alcohol amination is carried out in the presence of a complex catalyst comprising iridium and an amino acid.

Catalytic hydrogenation of amides to amines under mild conditions

Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd-Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines. Copyright

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

METHOD FOR THE CONTINUOUS PRODUCTION OF AN AMINE

The invention relates to a method for the continuous production of an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group containing ammonia and primary and secondary amines, at a temperature that ranges between 60 and 300 °C in the presence of a catalyst containing copper. According to the invention, the catalytically active mass of the catalyst contains the following prior to its reduction with hydrogen: 20 to 85 wt. % aluminium oxide (Al2O3), zirconium dioxide (ZrO2), titanium dioxide (TiO2) and/or silicon dioxide (SiO2); 1 to 70 wt. % copper compounds containing oxygen, calculated as CuO; 0 to 50 wt. % magnesium compounds containing oxygen, calculated as MgO; chromium compounds containing oxygen, calculated as Cr2O3; zinc compounds containing oxygen, calculated as ZnO; barium compounds containing oxygen, calculated as BaO; and/or calcium compounds containing oxygen, calculated as CaO; and less than 30 wt. % nickel compounds containing oxygen, calculated as NiO, in relation to the copper compounds containing oxygen, calculated as CuO. The reaction in the gas phase takes place isothermally in a tubular reactor.

Preparation process of aminoacetamide derivative

Disclosed herein are novel processes for preparing aminoacetamide derivatives, wherein: (1) a secondary amine is reacted with a 2-haloacetamide in the presence or absence of at least one solvent selected from water, lower alcohols, aromatic solvents and acetic acid esters; (2) an N-benzylideneamine derivative is reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is then reacted with a 2-haloacetamide; and (3) a primary amine is reacted with benzaldehyde to form an N-benzylideneamine derivative, this product is then reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is further reacted with a 2-haloacetamide. The 2-aminoacetamide derivatives are useful as intermediates for the preparation of novel antibiotics.

ELECTROCHEMICAL REDUCTIVE AMINATION. II. AMINATION OF ALIPHATIC ALDEHYDES WITH PRIMARY AMINES

The formation of a secondary amine by the electrolysis of an aqueous solution containing an aldehyde and a primary amine was studied.The formation of the secondary amines passes through the intermediate stage of an aldimine.The highest yield of secondary amine is attained at a molar ratio of primary amine to aldehyde of 1.2:1.As electrode material lead, cadmium, zinc, and copper may be used.As supporting electrolyte a phosphate buffer with a pH close to the pKa of the primary amine is recommended.By the method developed 32 amines with various structures were synthesized.

PHOSPHONIUM DIAZA-DIYLIDS AND AZA-YLDIID AS NEW AND EFFICIENT REAGENTS FOR PRIMARY AND SECONDARY AMINES SYNTHESIS

Metallated aminophosphonium ylids, diaza-diylids and aza-yldiid, are investigated as reagents for primary and secondary amines synthesis.

Titanium Induced Coupling of Imines to Symmetrical Vicinal (R*,R*)-Diamines

Symmetrical vicinal (R*,R*) -d,l-diamines were prepared from the corresponding imines and low valent titanium species generated by the action of titanium tetrachloride on amalgamated magnesium.

ZINC SULFIDE-CATALYZED PHOTOCHEMICAL CONVERSION OF PRIMARY AMINES TO SECONDARY AMINES

Nonmetallized ZnS catalizes efficiently the photochemical conversion of primary amines to secondary amines with liberation of ammonia under irradiation of the UV light of λ>290 nm.The conversion is interpreted as due to the two-hole-oxidation of primary amines to Schiff bases and their two-electron-reduction to secondary amines by the photogenerated electrons in ZnS.