20265-39-8

Basic information

• Product Name: 4-Amino-2-methoxypyridine
• Synonyms: 2-METHOXY-PYRIDIN-4-YLAMINE;4-AMINO-2-METHOXYPYRIDINE;2-METHOXY-4-AMINOPYRIDINE;2-Methoxypyridin-4-amine;2-Methoxy-pyridin-4-ylamine ,97%;2-Methoxy-4-pyridineamine;4-Amino-6-methoxypyridine;4-Amino-2-methoxypyridine ,97%
• CAS NO: 20265-39-8
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: -0
• Product Categories: Amines;blocks;Pyridines;Pyridine;Pyridine series;Boronic Acid
• Mol File: 20265-39-8.mol

Chemical Properties

• Melting Point: 87-88°C
• Boiling Point: 271.7 °C at 760 mmHg
• Flash Point: 118.1 °C
• Appearance: /
• Density: 1.139 g/cm³
• Vapor Pressure: 0.00635mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.29±0.30(Predicted)
• CAS DataBase Reference: 4-Amino-2-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-methoxypyridine(20265-39-8)
• EPA Substance Registry System: 4-Amino-2-methoxypyridine(20265-39-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 20265-39-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C6H8N2O/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3,(H2,7,8)

Upstream product

• 88511-26-6 2-iodo-pyridin-4-ylamine 
• 14395-39-2 2-methoxy-4-nitropyridine N-oxide 
• 14432-12-3 4-Amino-2-chloropyridine 
• 67-56-1 methanol 
• 1628-89-3 2-methoxypyridine 
• 20773-98-2 2-methoxypyridine N-oxide 
• 124-41-4 sodium methylate 

Downstream Products

• 96530-81-3 4-fluoro-2-methoxypyridine 
• 72716-86-0 4-cyano-2-methoxypyridine 
• 408502-23-8 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 96530-75-5 4-fluoro-1,2-dihydropyridin-2-one 
• 75279-35-5 N-(2-methoxy-pyridin-4-yl)-N'-phenylurea 
• 1428968-73-3 2-(4-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone 
• 1428968-74-4 2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone 
• 1580503-87-2 phenethyl 2-methoxypyridin-4-ylcarbamate 
• 1620846-76-5 5-chloro-2-(4-fluoro-2-methoxyphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)benzamide 
• 1620846-22-1 4-chloro-2-(4-fluoro-2-methoxyphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)benzamide 
• 1620847-19-9 4,5-dichloro-2-(4-fluoro-2-methoxyphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)benzamide 
• 1620846-46-9 2-(4-fluoro-2-methylphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-5-(trifluoromethoxy)benzamide 
• 1620847-16-6 2-(4-fluoro-2-methoxyphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(perfluoroethyl)benzamide 
• 1620846-28-7 4-cyano-2-(4-fluoro-2-methoxyphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)benzamide 

Relevant articles and documents

NICOTINIC RECEPTOR COMPOUNDS

Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.

SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS

Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.

We have introduced solubilizing functionality to a 3,6-disubstituted pyrazolo[1,5-a]pyrimidine series of KDR kinase inhibitors to improve the physical properties of these compounds. The addition of a basic side-chain to the 6-aryl ring, introduction of 3-pyridyl groups, and most significantly, incorporation of a 4-pyridinonyl substituent at the 6-position of the core are modifications that maintain and often enhance the intrinsic potency of this class of inhibitors. Moreover, the improvements in physical properties result in marked increases in cellular activity and more favorable pharmacokinetics in rats. The synthesis and SAR of these compounds are described.

Substituent Effects on the Isomer Ratios in the Rearrangement of Some 2- and 4-Nitraminopyridines

The preparation, and rearrangement in 92percent sulfuric acid, of 4-X-2-nitramino- (1), 2-X-4-nitramino- (2), and 6-X-2-nitramino-pyridines (3) is reported (X=H,Me,MeO,Br,Cl,CO2H).The product isomer ratios can be explained by differential electronic stabilization of the appropriate ? complexes for aromatic nitration and steric effects seem relatively unimportant.Deuteration had no effect on the product distribution