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1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE

    Cas No: 226396-63-0

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  • 226396-63-0 Structure
  • Basic information

    1. Product Name: 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE
    2. Synonyms: 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE
    3. CAS NO:226396-63-0
    4. Molecular Formula: C19H26FNO6S
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 226396-63-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE(226396-63-0)
    11. EPA Substance Registry System: 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE(226396-63-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 226396-63-0(Hazardous Substances Data)

226396-63-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 226396-63-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,3,9 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 226396-63:
(8*2)+(7*2)+(6*6)+(5*3)+(4*9)+(3*6)+(2*6)+(1*3)=150
150 % 10 = 0
So 226396-63-0 is a valid CAS Registry Number.

226396-63-0Relevant articles and documents

CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE INHIBITORS AND AGENTS FOR BORON NEUTRON CAPTURE THERAPY

-

Paragraph 00116, (2020/01/24)

Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase ("MMP") inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In parti

Carborane-Containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron-Capture Therapy (BNCT)

Lutz, Marlon R.,Flieger, Sebastian,Colorina, Andre,Wozny, John,Hosmane, Narayan S.,Becker, Daniel P.

, p. 1897 - 1908 (2020/09/01)

Based on the previously reported potent and selective sulfone hydroxamate inhibitors SC-76276, SC-78080 (SD-2590), and SC-77964, potent MMP inhibitors have been designed and synthesized to append a boron-rich carborane cluster by employing click chemistry

An Efficient Oxidation of Sulfides to Sulfones with Urea-Hydrogen Peroxide in the Presence of Phthalic Anhydride in Ethyl Acetate

Lutz, Marlon,Wenzler, Marta,Likhotvorik, Igor

supporting information, p. 2231 - 2234 (2018/04/16)

A metal-free, environmentally benign oxidation of substituted sulfides directly to their corresponding sulfones is described. Using urea-hydrogen peroxide and phthalic anhydride in ethyl acetate clean conversion into the sulfone was achieved without observation of the possible sulfoxide oxidation product.

Synthesis and structure-activity relationships of β- and α-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy

Becker, Daniel P.,Villamil, Clara I.,Barta, Thomas E.,Bedell, Louis J.,Boehm, Terri L.,DeCrescenzo, Gary A.,Freskos, John N.,Getman, Daniel P.,Hockerman, Susan,Heintz, Robert,Howard, Susan Carol,Li, Madeleine H.,McDonald, Joseph J.,Carron, Chris P.,Funckes-Shippy, Chris L.,Mehta, Pramod P.,Munie, Grace E.,Swearingen, Craig A.

, p. 6713 - 6730 (2007/10/03)

α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the β-sulfones subsequently led to the discovery of hitherto unknown α-sulfone h

Aromatic sulfone hydroxamates and their use as protease inhibitors

-

Page 148, (2010/02/05)

This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.

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