28902-82-1

Basic information

• Product Name: poly(acryloylmorpholine)
• Synonyms: poly(acryloylmorpholine);Morpholine,4-(1-oxo-2-propenyl)-, homopolymer;Morpholine,4-(1-oxo-2-propenyl)-,homopolymer
• CAS NO: 28902-82-1
• Molecular Formula: C7H11NO2
• Molecular Weight: 141.16774
• Mol File: 28902-82-1.mol

Chemical Properties

• Boiling Point: 296.8°Cat760mmHg
• Flash Point: 133.3°C
• Appearance: /
• Density: 1.074g/cm³
• CAS DataBase Reference: poly(acryloylmorpholine)(CAS DataBase Reference)
• NIST Chemistry Reference: poly(acryloylmorpholine)(28902-82-1)
• EPA Substance Registry System: poly(acryloylmorpholine)(28902-82-1)

Safety Data

• Hazardous Substances Data: 28902-82-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 814-68-6 acryloyl chloride 
• 860248-52-8 4-(3-methoxy-propionyl)-morpholine 
• 10024-89-2 morpholin hydrochloride 
• 74-86-2 acetylene 
• 79-10-7 acrylic acid 
• 71145-92-1 N-(propadienyloxy)morpholine 
• 71145-90-9 N-prop-2-ynylmorpholine N-oxide 
• 54022-76-3 2-chloro-1-(4-morpholino)propan-1-one 
• 2620-13-5 α-bromomorpholinopropanamide 
• 27097-66-1 2-hydroxy-1-(morpholin-4-yl)-1-propanone 
• 3773-84-0 β-morpholinyl-N,N-morpholinylpropionic acid amide 
• 100-39-0 benzyl bromide 
• 108-24-7 acetic anhydride 

Downstream Products

• 353476-50-3 C₇H₁₀BrNO₂ 
• 1442644-23-6 methyl (2R,4R,5S)-4-(morpholine-4-carbonyl)-5-phenylpyrrolidine-2-carboxylate 
• 1435912-84-7 (E)-1-morpholino-3-(4-phenoxyphenyl)prop-2-en-1-one 
• 1435912-83-6 (E)-3-(4-acetylphenyl)-1-morpholinoprop-2-en-1-one 
• 16619-19-5 N-morpholinocinnamide 
• 1510826-39-7 2-(9-benzyl-9H-purin-6-yl)-1-morpholino-4-phenylbutan-1-one 

Relevant articles and documents

Potassium Base-Catalyzed Michael Additions of Allylic Alcohols to α,β-Unsaturated Amides: Scope and Mechanistic Insights

We report herein the first KHMDS-catalyzed Michael additions of allylic alcohols to α,β-unsaturated amides through allylic isomerization. The reaction proceeds smoothly in the presence of only 5 mol% of KHMDS to afford a variety of 1,5-ketoamides in high yields. Mechanistic investigations, including experimental and computational studies, reveal that the KHMDS-catalyzed in-situ generation of the enolate from the allylic alcohol through a tunneling-assisted 1,2-hydride shift is the key to the success of this transformation. (Figure presented.).

Synthesis method of 4-acryloylmorpholine

The invention discloses a synthesis method of 4-acryloylmorpholine. The synthesis method mainly comprises the following two steps: 1) carrying out dehydration condensation on propionic acid and morpholine under the action of DCC to obtain an intermediate 4-propionylmorpholine; and 2) carrying out a Saegusa reaction on the 4-propionylmorpholine and oxygen under the catalysis of palladium acetate under the condition of a strong base to form the target product 4-acryloylmorpholine. The synthesis method of the 4-acryloylmorpholine can be implemented under normal pressure, reaction temperature is mild, byproducts are few, a reaction catalyst can be recycled, and the synthesis method has good industrialization prospects.

Method for catalytically synthesizing acrylamide compound by MOFs-derived zirconium-based ternary oxide solid acid

The invention provides a catalytic synthesis of acrylamide compounds with zirconium-based ternary oxide solid acid as a catalyst, and the low-temperature activity is good. In the synthesis process, the acid is small, the reaction conditions are mild and controllable, the byproducts are few, the reaction yield is effectively improved, the purity is high, the quality is good, and the method is suitable for large-scale production.

Iridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives

Transition-metal-catalyzed asymmetric hydroalkenylation of alkenes provides an atom-economical method to build molecular complexity from easily available materials. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of unconjugated alkenes with acrylamides and acrylates. The catalytic hydroalkenylation of norbornene derivatives occurred to form products with allylic stereocenters with high chemo-, regio-, and stereoselectivities. DFT calculations revealed that the migratory insertion is irreversible and the enantiodetermination step.

Copper-Catalyzed Propargylation of Nitroalkanes

Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient α-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these α-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered N-heterocycles such as pyrroles and 2-pyrrolines.

Process for Productions of Formamides and Acrylamides

This invention relates to performance chemicals field, it discloses a novel and green process for simultaneous productions of formamides as well as mono- and multi-functional acrylamides under very mild conditions and with high efficiency. These substances are widely useful as industrial solvents or raw materials, in particular acrylamides are important olefinically-unsaturated polymerizable monomers in photo-curing materials.

Preparation method of acryloylmorpholine

The invention provides a preparation method of acryloylmorpholine, which comprises the following steps: 1. adding morpholine, acrylic anhydride, a polymerization inhibitor and a catalyst into a deviceprovided with condensation reflux while stirring, and stirring for 2 hours to obtain a mixture A; and 2, filtering the mixture A obtained in the step 1 to obtain a filtrate, and distilling the filtrate to collect a fraction with a temperature range of 65-85 DEG C under 8-12 kPa to obtain the acryloylmorpholine. The yield of the acryloylmorpholine prepared by the method is extremely high and is greater than 90%; and the purity of the product measured by gas chromatography is higher and is greater than 98.0%, so that the technical problems of lower yields and more byproducts in the prior art are solved. Besides, the preparation method is simple and convenient in process and mild in preparation temperature, hardly generates three wastes, is an efficient and environment-friendly synthesis method, and is suitable for large-scale popularization and application.

Synthesis method for preparing acryloyl morpholine from acrylamide as raw material

The invention relates to a synthesis method for preparing acryloyl morpholine from acrylamide as a raw material and belongs to the field of chemical product synthesis methods. The synthesis method ofthe acryloyl morpholine (ACMO) comprises the following steps: 1) under a condition of 0-5 DEG C, performing a Diels-Alder reaction on acrylamide and furan so as to obtain an acrylamide addition intermediate; 2) performing refluxing on the addition intermediate, morpholine and a catalyst at 100-160 DEG C for 12-24 hours, and performing an amino exchange reaction so as to obtain a propionyl morpholine derivative intermediate; and 3) performing thermal cracking on a propionyl morpholine derivative with a lewis acid catalyst at 130-170 DEG C at 1-3kPa, performing rectification so as to obtain acryloyl morpholine, performing freeze recycling on furan, and circulating the furan for the process. By adopting the acryloyl morpholine synthesis method provided by the invention, the contents of toxicand harmful gases and VOCs (volatile organic compounds) in a production process can be effectively reduced, the reaction process is simple, products and recycled raw materials are easy to separate, the reaction condition is easy to control, the security is high, the reaction yield is high, the byproduct amount is small, the aftertreatment is simple, the product purity is high, and industrial production is easy.

Preparation method of N-acryloyl morpholine

The invention discloses a preparation method of N-acryloyl morpholine, and particularly relates to a method for preparing N-acryloyl morpholine by a condensation method; acrylic acid and morpholine are used as raw materials, and a dehydrating agent is used for dehydration. The preparation conditions are mild, and the purification process is simple; the product is easy to separate and not easy to polymerize; the preparation method has the advantages of high yield, high product purity and the like in product synthesis.

N, N - disubstituted α, β - unsaturated carboxylic acid amide of (by machine translation)

[Problem] to compounds derived from compounds containing chlorine atoms contained in the byproducts of the no possibility, stable compound to N, N - disubstituted α, β - unsaturated carboxylic acid amide manufacturing method. [Solution] N, N - di-substituted carboxylic acid amide phenols with formaldehyde, in the presence of a catalyst containing no chlorine atoms, in a nonaqueous liquid phase reaction, N, N - disubstituted α, β - unsaturated carboxylic acid amide having a process, wherein the formaldehyde, paraformaldehyde, trioxane is one selected from formaldehyde and anhydrous 1, 3, 5 - 1, and the catalyst, an acidic catalyst or a basic catalyst N, α N - disubstituted, with production of β - unsaturated carboxylic acid amide. [Drawing] no (by machine translation)