3410-94-4Relevant articles and documents
Total synthesis of lavendamycin by a [2+2+2] cycloaddition
Nissen, Felix,Detert, Heiner
experimental part, p. 2845 - 2853 (2011/06/26)
The total synthesis of the bacterial-derived, pentacyclic, antitumor antibiotic lavendamycin has been achieved through a highly convergent strategy. The key step of this synthesis is a ruthenium-catalyzed [2+2+2] cycloaddition of an electron-deficient nit
Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds
Dantas De Araujo, Aline,Christensen, Caspar,Buchardt, Jens,Kent, Stephen B. H.,Alewood, Paul F.
supporting information; experimental part, p. 13983 - 13986 (2012/01/06)
In the image: The design and synthesis of peptidomimetics that maintain the configuration of the triad Asp-Thr-Gly found in the catalytic site of the HIV-1 protease (see scheme) are described. By using regioselective nitration and reductive lactamisation,
PEG-N2O4: An efficient nitrating agent for the selective mono- and dinitration of phenols under mild conditions
Zolfigol, Mohammad Ali,Madrakian, Elaheh,Ghaemi, Ezat,Niknam, Khodabakhsh
, p. 3366 - 3374 (2008/12/22)
N2O4 was easily impregnated on polyethyleneglycol to give a stable reagent. The polyethyleneglycol-N2O4 (PEG-N2O4) system was used as an effective nitrating agent for the nitration of phenols. Mono- and dinitrophenols can be obtained via direct nitration of phenols in the presence of PEG-N2O4 at room temperature in moderate to high yields. Copyright Taylor & Francis Group, LLC.
The total synthesis of neoamphimedine
LaBarbera, Daniel V.,Bugni, Tim S.,Ireland, Chris M.
, p. 8501 - 8505 (2008/02/13)
(Chemical Equation Presented) Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is
Highly efficient catalytic nitration of phenolic compounds by nitric acid with a recoverable and reusable Zr or Hf oxychloride complex and KSF
Shi, Min,Cui, Shi-Cong,Yin, Wan-Po
, p. 2379 - 2384 (2007/10/03)
Phenolic compounds can be nitrated with 60% nitric acid (1.2 equiv.) in the presence of catalytic amounts of a Zr or Hf oxychloride complex and montmorillonite KSF to give the corresponding nitrated products in good yields in a heterogeneous catalytic system. The co-catalyst and montmorillon ite can be easily recovered and reused in the next batch of nitration. This is a practical process for the nitration of phenolic compounds in a clean way. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
Nitration of phenolic compounds by metal-modified montmorillonite KSF
Yin, Wan-Po,Shi, Min
, p. 10861 - 10867 (2007/10/03)
The nitration of phenolic compounds with 60% nitric acid (1.2 equiv) has been carried out in the presence of metal-modified montmorillonite KSF, prepared from different metals (V, Mo, W; Sc, La, Yb, Eu, In, Bi, Ti, Zr, Hf) and KSF or nitric acid treated HKSF, as catalysts. These catalysts showed good stabilities and high catalytic activities in nitration process. In addition, these catalysts can be recovered easily and reused for many times in nitration. This process is an eco-safer and environment-benign way for clean synthesis of nitrated phenolic compounds.
Regioselective preparation of 5-amino- and 6-amino-1,3-benzoxazole-4,7- diones from symmetrical diaminophenol and aminoresorcinol
Bréhu, Laetitia,Fernandes, Anne-Cécile,Lavergne, Olivier
, p. 1437 - 1440 (2007/10/03)
Regioisomeric 5-amino- and 6-amino- 1,3-benzoxazole-4,7-diones were prepared from 2,6-diamino-4-methoxyphenol and 2-amino-5-methoxyresorcinol, respectively. These symmetrical precursors have the property to be antisymmetrical to each other with respect to
Trichloroisocyanuric Acid/NaNO2/wet SiO2 as an Efficient System for the Selective Dinitration of Phenols under Solvent-free Conditions
Zolfigol, Mohammad Ali,Madrakian, Elaheh,Ghaemi, Ezat
, p. 2222 - 2224 (2007/10/03)
Dinitrophenols can be obtained via direct nitration of phenols with trichloroisocyanuric acid, NaNO2 and wet SiO2 at room temperature under solvent-free conditions with moderate to high yields.
A New Method for Nitration of Phenolic Compounds
Shi, Min,Cui, Shi-Cong
, p. 1197 - 1202 (2007/10/03)
Phenolic compounds can be nitrated by 65% nitric acid in the presence of catalytic amounts of montmorillonite KSF and bismuth(III) nitrate to give the corresponding nitrated products in good yields in a heterogeneous phase. The co-catalyst of KSF and Bi(NO3)3 can be easily recovered and reused in the next batch of nitration.
Nitrodecarboxylation and nitrodeformylation of some electron-rich benzoic acids and benzaldehydes
Cotelle, Philippe,Catteau, Jeanpierre
, p. 4105 - 4112 (2007/10/03)
The nitration ipso to a carboxylic or formyl group of disubstituted and trisubstituted benzoic acids and benzaldehydes using nitric acid in acetic acid is described.
