957110-20-2Relevant academic research and scientific papers
An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: An ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent
Li, Linfeng,Abraham, Adedoyin D.,Zhou, Qiong,Ali, Hadi,O'Brien, Jeremy V.,Hamill, Brayden D.,Arcaroli, John J.,Messersmith, Wells A.,LaBarbera, Daniel V.
, p. 4833 - 4850 (2014)
Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a the
TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USE AS THERAPEUTIC AGENTS
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Page/Page column 23, (2013/05/23)
The invention provides methods of inhibiting the growth or metastasis of cancer in a mammal by inhibiting TopoIIa in the mammal. The invention also provides small molecule inhibitors of TopoIIa useful in the methods of the invention and pharmaceutical com
The total synthesis of neoamphimedine
LaBarbera, Daniel V.,Bugni, Tim S.,Ireland, Chris M.
, p. 8501 - 8505 (2008/02/13)
(Chemical Equation Presented) Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is
