430-71-7

Basic information

• Product Name: PROPIONYL FLUORIDE
• Synonyms: propanoylfluoride;Propanoyl-fluoride-;PROPIONYL FLUORIDE;Propionylfluoride97%;Propanoic acid fluoride;Propionic acid fluoride;Propanoyl fluoride 97%;Propanoylfluoride97%
• CAS NO: 430-71-7
• Molecular Formula: C₃H₅FO
• Molecular Weight: 76.07
• EINECS: 207-067-7
• Mol File: 430-71-7.mol

Chemical Properties

• Boiling Point: 43
• Flash Point: 3.2 °C
• Appearance: /
• Density: 0.9720
• Vapor Pressure: 369mmHg at 25°C
• Refractive Index: 1.3290
• CAS DataBase Reference: PROPIONYL FLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPIONYL FLUORIDE(430-71-7)
• EPA Substance Registry System: PROPIONYL FLUORIDE(430-71-7)

Safety Data

• Hazard Codes: C,F
• Statements: 11-34
• Safety Statements: 16-26-36/37/39
• RIDADR: 2924
• HazardClass: FLAMMABLE, CORROSIVE
• Hazardous Substances Data: 430-71-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Propionyl fluoride is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its ability to introduce the propionyl group into compounds makes it a valuable component in the development of new drugs and pesticides.
Used in Organic Chemistry Research:
As a reagent, propionyl fluoride is utilized for the introduction of the propionyl group into a wide range of organic compounds. This contributes to the advancement of organic chemistry by enabling the synthesis of new molecules with potential applications in various fields.
Used in Nucleophilic Substitution Reactions:
Due to its high reactivity, propionyl fluoride is employed in nucleophilic substitution reactions with various nucleophiles. This allows for the formation of new chemical bonds and the creation of novel compounds with specific properties and uses.

InChI:InChI=1/C3H5FO/c1-2-3(4)5/h2H2,1H3

Upstream product

• 357-83-5 N-(2-chloro-1,1,2-trifluoroethyl)diethylamine 
• 137-40-6 sodium proprionate 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 802294-64-0 propionic acid 
• 455-32-3 benzoyl fluoride 
• 400-54-4 propionyltrifluoroacetone 
• 7789-21-1 fluorosulphonic acid 

Downstream Products

• 5337-93-9 4'-methylpropiophenone 
• 349-43-9 ethyl 2-fluoropropionate 
• 352-23-8 ethyl 3,3,3-trifluoropropanoate 
• 399-92-8 2,3,3,3-tetrafluoropropionic acid ethyl ester 
• 10117-10-9 3-Fluor-propionsaeure-aethylester 
• 69750-34-1 2-methyl-6-propanoyl naphthalene 
• 14333-26-7 hydrogen fluoride 
• 108448-63-1 Co₂(CO)6HCCC₆H₉(OCH₂CHCH₂)(COC₂H₅) 
• 590-18-1 (Z)-2-Butene 
• 591-34-4 s-butyl propionate 
• 624-64-6 trans-2-Butene 
• 359-01-3 2-fluorobutane 
• 758-96-3 N,N-dimethyl-propanamide 
• 10264-12-7 N-benzylpropanamide 

Relevant articles and documents

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)

This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl fluorides can be formed from a range of acids under mild conditions. We also demonstrate that PFP can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides in yields of ≤94%.

Direct amidation of acid fluorides using germanium amides

Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method for their preparation is presented where germanium amides Ph3GeNR2convert acid fluorides directly to amides. These germanium amides serve to abstract the fluorine atom of the acid fluoride and transfer their amide group -NR2to the carbonyl carbon, and so function as amidation reagents.

METHOD FOR PRODUCING FLUORINATED HYDROCARBONS

Provided is a method for industrially advantageously producing a fluorinated hydrocarbon (3). The disclosed method for producing a fluorinated hydrocarbon represented by formula (3) includes bringing into contact, in a hydrocarbon-based solvent, a secondary or tertiary ether compound represented by formula (1) below with an acid fluoride represented by formula (2) in the presence of lithium salt or sodium salt (in the formulae, R1 and R2 each represent a C1-3 alkyl, and R1 and R2 may be bonded to each other to form a ring structure; R3 represents a hydrogen atom, methyl, or ethyl; and R4 and R5 each represent methyl or ethyl).

MANUFACTURING METHOD OF FLUORINATED HYDROCARBON

PROBLEM TO BE SOLVED: To provide a method for industrially advantageously manufacturing fluorinated hydrocarbon (3). SOLUTION: There is provided a method for manufacturing fluorinated hydrocarbon represented by the formula (3), including contacting a secondary or tertiary ether compound represented by the formula (1) and acid fluoride represented by the formula (2) in the presence of a silver salt in a hydrocarbon solvent. R1 and R2 are each independently a C1 to 3 alkyl group, R1 and R2 may bind to form a ring structure, R3 is H, a methyl group or an ethyl group, R4 and R5 are each independently a methyl group or an ethyl group. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

METHOD FOR MANUFACTURING FLUORINATED HYDROCARBON

The present invention is a method for producing a fluorinated hydrocarbon represented by a structural formula (3), wherein an ether compound represented by a structural formula (1) and an acid fluoride represented by a structural formula (2) are brought into contact with each other in a hydrocarbon-based solvent, in the presence of a catalyst in which boron trifluoride is supported on a metal oxide: wherein R1 and R2 represent an alkyl group having 1 to 3 carbon atoms, R3 represents a hydrogen atom, a methyl group or an ethyl group, and R4 and R5 represent a methyl group or an ethyl group; and R4 and R2 may be bonded to each other to form a cyclic structure. Through the present invention, a method for industrially advantageously producing 2-fluorobutane is provided.

METHOD FOR PRODUCING FLUORINATED HYDROCARBON

The present invention is a method for producing a fluorohydrocarbon represented by a structural formula (3) comprising bringing a secondary or tertiary ether compound represented by a structural formula (1) into contact with an acid fluoride represented by a structural formula (2) in a hydrocarbon-based solvent in the presence of a boron trifluoride complex. (In structural formulae (1) to (3), each of R1 and R2 represents an alkyl group having 1 to 3 carbon atoms, R3 represents a hydrogen atom, a methyl group, or an ethyl group, and each of R4 and R5 represents a methyl group or an ethyl group, provided that R1 and R2 are optionally bonded to each other to form a ring structure.)

The fluorinated hydrocarbon production (by machine translation)

2 - fluorobutane industrially advantageous production method [a]. (1) the ether compound represented by the formula [a], equation (2) as shown in the di-acid, a hydrocarbon-based solvent, in the presence of boron trifluoride catalyst is carried on a polyvinylpyrrolidone, contacting, formula (3) represented by the production of fluorinated hydrocarbons. (R1 And R2 The alkyl groups are independently C1 a-3; R1 And R2 The coupling may form a ring structure; R3 Is H, a methyl group or an ethyl group; R4 Is a methyl group or an ethyl group; R5 Is a methyl group or ethyl group)[Drawing] no (by machine translation)

METHOD FOR PRODUCING FLUORINATED HYDROCARBON

PROBLEM TO BE SOLVED: To provide an industrially advantageous method for producing a fluorinated hydrocarbon such as 2-fluorobutane useful as etching gas for a dry etching process. SOLUTION: There is provided a method for producing a fluorinated hydrocarbon represented by formula (3) by bringing an ether compound represented by formula (1) into contact with an acid fluoride represented by formula (2) in a halogenated hydrocarbon solvent in the presence of a metal halide represented by formula (4): MX3 (M represents a metal atom; X represents a chlorine atom or a bromine atom) (R1 and R2 each independently represent an alkyl group having 1-3 carbon atoms; R1 and R2 may be bonded to form a ring structure; R3 represents H, a methyl group or an ethyl group; R4 and R5 each independently represent a methyl group or an ethyl group.) SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

METHOD FOR PRODUCING FLUORINATED HYDROCARBON

PROBLEM TO BE SOLVED: To provide a method for industrially advantageously producing a fluorinated hydrocarbon. SOLUTION: The method for producing a fluorinated hydrocarbon represented by formula (3) comprises bringing a secondary or tertiary ether compound represented by formula (1) into contact with an acid fluoride represented by formula (2) in the presence of a compound having an N-X bond (X is a halogen atom selected from a chlorine atom, a bromine atom, and an iodine atom) in a halogenated hydrocarbon-based solvent. (R1 and R2 are each independently a C1-C3 alkyl group; R3 is H, a methyl group, or an ethyl group; R4 and R5 are each a methyl group or an ethyl group; and R1 and R2 may be bonded together to form a ring structure.) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT