51366-39-3Relevant articles and documents
Structural investigations of 3-acetamido-4-nitrobenzal derivatives
Rusek,Bryndal,Picur,Lis,Brzostowska
, p. 241 - 257 (2001)
N-(p-dimethylaminophenyl)-α-(3acetamido-4-nitrophenyl)nitrone (I) and 3-acetamido-4-nitrobenzylpyridinium bromide (II) were synthesized and their crystal structures were determined by X-ray diffraction methods. The geometry of carbon-nitrogen bond in nitrone is trans. In I the acetamido moiety slightly deviates from plane to the rest of molecule. The intramolecular N-H···O and C-H···O as well as intermolecular C-H···O hydrogen bonds stabilize the crystal structures of both the compounds. NMR investigations of II have given spectra with extra signals in comparison to the number of expected that suggests that dominating structure of this compound observed in crystal state coexists in solution with comparable amount of the additional form due to an interaction with solvent and increasing conformational freedom. For II duplication of signal number is observed for the 3-acetamido-4-nitrobenzyl substituent due to formation only of two different edge to face structures of this compound in DMSO and D2O solution. For I in DMSO solution the major form has perpendiculair orientation of N,N-dimethylaniline substituent on nitrone bond against the plane containing the rest of the molecule.
Transition-metal-free mono- or dinitration of protected anilines
Dai, Enrui,Dong, Ying,Dong, Yongrui,Kong, Rui,Liang, Deqiang,Liu, Guangzhang,Ma, Yinhai,Wu, Qiong
, (2020/04/27)
An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity.
COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF
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Paragraph 364-366, (2019/08/29)
The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
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, (2015/11/16)
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride
Lu, Yang,Li, Yaming,Zhang, Rong,Jin, Kun,Duan, Chunying
supporting information, p. 9422 - 9427 (2013/10/08)
An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions.
Nitric acid in the presence of P2O5 supported on silica gel - A useful reagent for nitration of aromatic compounds under solvent-free conditions
Hajipour, Abdol Reza,Ruoho, Arnold E.
, p. 8307 - 8310 (2007/10/03)
A variety of aromatic compounds are nitrated to parent nitro aromatic compounds under solvent-free conditions using 65% nitric acid in the presence of P2O5 supported on silica gel is described. This methodology is useful for nitration of activated and deactivated aromatic rings.
A fast and mild method for nitration of aromatic rings
Hajipour, Abdol R.,Ruoho, Arnold E.
, p. 221 - 226 (2007/10/03)
The use of benzyltriphenylphosphonium nitrate (PhCH2Ph 3P+NO3-) (BTPPN) as a useful reagent for nitration aromatic compounds in the presence of methanesulfonic anhydride under solvent-free conditions is described. This methodology is useful for nitration of activated aromatic rings.
Diaminopuridine-containing thiourea inhibitors of herpes viruses
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, (2008/06/13)
Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications
Suzuki, Hitomi,Tatsumi, Atsuo,Ishibashi, Taro,Mori, Tadashi
, p. 339 - 344 (2007/10/02)
In the presence of ozone, anilides 1 can be nitrated rapidly with nitrogen dioxide in chloroform at 0 deg C to give a high proportion of ortho-nitro derivatives (ortho:para = 1.2-4.4) in good yields.The phenyl esters 15 can be similarly nitrated on the aromatic ring without significant cleavage of the ester bond, giving a mixture of isomeric nitro derivatives in which the ortho-isomer predominantes (ortho:para = 1.1-1.5).The oridin of the enhanced ortho reactivity is discussed in terms of an electron-transfer process involving the nitrogen trioxide as initial electrophile.
Ortho-Selective Nitration of Acetanilides with Nitrogen Dioxide in the Presence of Ozone
Suzuki, Hitomi,Ishibashi, Taro,Murashima, Takashi,Tsukamoto, Kenkichi
, p. 6591 - 6594 (2007/10/02)
In the presence of ozone, nitrogen dioxide rapidly reacts with acetanilides ortho-selectively at low temperatures, giving a high proportion of ortho-nitro derivatives in good yields.
