58268-09-0Relevant articles and documents
Metal-free greener method for the synthesis of densely functionalized pyrroles via a one-pot three-component reaction
Fatahpour, Maryam,Hazeri, Nourallah,Maghsoodlou, Malek Taher,Lashkari, Mojtaba
, p. 111 - 116 (2019)
Abstract: A convenient and straightforward acid-promoted synthesis of a new series of polyfunctionalized pyrroles has been developed based on a one-pot three-component reaction of acetoacetanilide, benzoin, and ammonium acetate/diverse anilines in acetic
Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones
Wei, Xiao-Hong,Li, Zhen-Hua,Zhao, Lian-Biao,Zhang, Ping,Zhou, Han-Cheng,Wang, Yan-Bin
, p. 32081 - 32084 (2019)
A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T+BF4- as an oxidant has been developed. This transformation was achieved by direct C-H oxi
Catalyst-free facile and efficient one-pot synthesis of densely functionalized pyrroles and α-amino ketones
Vanga, Sivarama Krishna Reddy,Bollikolla, Hari Babu,Peruri, V. V. Satyanarayana
supporting information, p. 892 - 899 (2021/02/01)
An efficient catalyst-free one-pot three-component synthesis of penta-substituted pyrroles has been successfully developed. A variety of penta-substituted pyrroles were straightforwardly synthesized from good to excellent yields (78%–93%) by using easily
Preparation method of alpha-aryl alpha-aminoketone compounds
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Paragraph 0038-0039, (2020/01/25)
The invention discloses a preparation method of alpha-aryl alpha-aminoketone compounds. The method comprises the following steps: 1) putting an alpha-aminocarbonyl compound, arylboronic acid, a catalyst and an oxidant into a reaction container, introducin
Synthesis and lung cancer cell line study of pyrrolo[2,3-d]pyrimidine analogs
Dholakia, Sandip P.,Kanada, Kaushik B.,Sureja, Dipen K.,Patel, Jitendra S.
, p. 367 - 372 (2020/01/03)
Three series of new pyrrolo[2,3-d]pyrimidines having diverse groups at position C4 and N7 of the pyrrolo[2,3-d]pyrimidine core were synthesized and their cell line study on the National Cancer Institute (NCI) H1 299 lung cancer cell line was performed. The details of the synthetic methods and characterization data of the synthesized compounds have been presented in this study. Compounds 08a, 08h, 08j, 09h, 09i, 09j, 09m, 09n, and 09o showed excellent anticancer activity compared to standard doxorubicin half maximal inhibitory concentration value on NCI H1 299 (lung cancer cell line) which was nontoxic to normal Vero cell line.
SnCl2·2H2O-Catalyzed Solvent-Free Synthesis of α-Amino Ketones and Tetrasubstituted Pyrazines
Tamaddon, Fatemeh,Dehghani Tafti, Arefeh
, p. 2217 - 2220 (2016/10/11)
Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl2·2H2O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl2·2H2O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.
Design, synthesis, assessment, and molecular docking of novel pyrrolopyrimidine (7-deazapurine) derivatives as non-nucleoside hepatitis C virus NS5B polymerase inhibitors
Mohamed, Mosaad S.,Sayed, Amira I.,Khedr, Mohammed A.,Soror, Sameh H.
, p. 2146 - 2157 (2016/04/20)
Hepatitis C virus (HCV) infection is highly persistent and presents an unmet medical need requiring more effective treatment options. This has spurred intensive efforts to discover novel anti-HCV agents. The RNA-dependent RNA polymerase (RdRp), NS5B of HC
Highly stereoselective synthesis of β-amino ketones via a mannich reaction catalyzed by cellulose sulfuric acid as a biodegradable, efficient, and recyclable heterogeneous catalyst
Nemati, Firouzeh,Fakhaei, Amir Soheyl,Amoozadeh, Ali,Hayeniaz, Yaser Saeidi
experimental part, p. 3695 - 3702 (2011/10/09)
The efficient use of cellulose sulfuric acid as a heterogeneous catalyst promotes three-component, one-pot Mannich reaction of various ketones, aromatic aldehydes, and aromatic amines in ethanol to make the corresponding β-amino ketones with high stereose
Thiazolium-derived N-heterocyclic carbene-catalyzed cross-coupling of aldehydes with unactivated imines
Li, Gong-Qiang,Dai, Li-Xin,You, Shu-Li
, p. 852 - 854 (2007/10/03)
Cross-coupling of aromatic aldehydes or benzoins with unactivated imines catalyzed by an N-heterocyclic carbene (NHC) affords α-amino ketones smoothly. The Royal Society of Chemistry.
2-(4-chloroanilino)- and 2-(4-methoxyanilino)-1,2-diphenylethanone
Batsanov, Andrei S.,Goeta, Andres E.,Howard, Judith A.K.,Soto, Bernardino,Au-Alvarez, Oscar
, p. o304-o306 (2007/10/03)
The title compounds, C20H16ClNO and C 21H19NO2, adopt syn orientations of the C=O and N - H bonds but, like their analogues, form no strong intermolecular hydrogen bonds.