616-29-5

Basic information

• Product Name: 1,3-Diamino-2-propanol
• Synonyms: 1,3-diamino-2-propano;1,3-DIAMINO-2-HYDROXYPROPAN;1,3-DIAMINO-2-HYDROXYPROPANE;1,3-DIAMINO-2-PROPANOL;1,3-DIAMINOPROPAN-2-OL;2-HYDROXY-1,3-DIAMINOPROPANE;1,3-Diamino-2-hydroxypropane, tech;2-hydroxy-1,3-propylenediamine
• CAS NO: 616-29-5
• Molecular Formula: C₃H₁₀N₂O
• Molecular Weight: 90.12
• EINECS: 210-474-2
• Product Categories: Aliphatics;Amines
• Mol File: 616-29-5.mol

Chemical Properties

• Melting Point: 40-44 °C(lit.)
• Boiling Point: 235°C
• Flash Point: >230 °F
• Appearance: White to yellow/Low Melting Solid
• Density: 1.0352 (rough estimate)
• Vapor Pressure: 0.00844mmHg at 25°C
• Refractive Index: 1.4610 (estimate)
• Storage Temp.: 2-8°C
• Solubility: water: soluble1g/10 mL
• PKA: 9.69, 7.93(at 20℃)
• Water Solubility: Very soluble in water.
• BRN: 741859
• CAS DataBase Reference: 1,3-Diamino-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diamino-2-propanol(616-29-5)
• EPA Substance Registry System: 1,3-Diamino-2-propanol(616-29-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: 3259
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 616-29-5(Hazardous Substances Data)

Usage

Uses

1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.It is a precursor to synthesize the fluorogenic dsDNA binder, N1,N3-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).It can also be used as a branching unit in the synthesis of peptide dendrimers.

Purification Methods

Dissolve it in an equal amount of water, shake it with charcoal and distil it at 68o/0.1mm. The distillate solidifies. It is too viscous to be distilled through a packed column. [Beilstein 4 IV 1694.]

InChI:InChI=1/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2/p+2

Upstream product

• 96-23-1 1,3-Dichloro-2-propanol 
• 57011-48-0 1,3-diazido 2-propanol 
• 106-89-8 epichlorohydrin 
• 5455-98-1 2-oxiranylmethylisoindole-1,3-dione 
• 73825-95-3 N,N'-(2-hydroxy-propanediyl)-bis-phthalimide 
• 7647-01-0 hydrogenchloride 
• 10035-10-6 hydrogen bromide 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 

Downstream Products

• 73825-95-3 N,N'-(2-hydroxy-propanediyl)-bis-phthalimide 
• 6285-24-1 NSC5485 
• 124052-98-8 2-benzyl-1,4,5,6-tetrahydro-pyrimidin-5-ol 
• 58708-63-7 3-Amino-2-hydroxypropan-1-dithiocarbaminsaeure 
• 39654-32-5 N,N'-bisbenzylidene-1,3-diamino-2-propanol 
• 133345-52-5 N,N′-bis-(salicylidene)(propylene-2-ol)-1,3-diamine 
• 119244-91-6 (3-benzyloxycarbonylamino-2-hydroxypropyl)-carbamic acid benzyl ester 
• 64049-31-6 2-Chloro-N-[3-(2-chloro-acetylamino)-2-hydroxy-propyl]-acetamide 
• 119244-96-1 N,N',O-tris(p-tolylsulfonyl)-1,3-diamino-2-hydroxypropane 
• 88635-66-9 5-methoxysalicylaldehyde-2-hydroxy-1,3-propanediamine 
• 54622-43-4 2-hydroxypropylene-1,3-diamino-N,N,N',N'-tetramethylenephosphonic acid 
• 155168-37-9 3-[{3-[Bis-(2-phenoxycarbonyl-ethyl)-amino]-2-hydroxy-propyl}-(2-phenoxycarbonyl-ethyl)-amino]-propionic acid phenyl ester 
• 80239-63-0 N-(3-amino-2-hydroxypropyl)-2-(tritylamino)acetamide 
• 122413-32-5 N,N,N',N'-tetrakis(2-pyridylmethyl)-1,3-diamino-2-propanol 

Relevant articles and documents

Method for preparing polyamine by direct ammoniation of polyhydroxy compound

A method for preparing polyamine by direct ammoniation of a polyhydroxy compound is disclosed. By using a polyhydroxy compound, ammonia gas or liquefied ammonia as a raw material and using a carrier-loaded liquid-phase reduced transition metal as a catalyst, an ammoniation reaction of the polyhydroxy compound under mild conditions is realized. The catalyst has high selectivity of polyamine. The catalyst can be recovered and recycled.

Hydrogels from biopolymers

Methods are disclosed for preparing linear or/and partial precross-linked poly-g-glutamic acid nanoparticle products, their reaction with compounds which contain vinyl groups, and the polymerization by chemical initiation or photopolymerization of these by light of predetermined wavelength. The final products of the present invention are useful as local drug delivery systems, dental surgery, and for inhibition of post-surgical adhesion. The hydrogels made from the biopolymers of the present invention may also be used in controlled release devices, superabsorbent materials and biomaterials like enzyme immobilization.

A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines

N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.

Synthesis and antifungal activity of novel bisdithiocarbamate derivatives of carbohydrates against Fusarium oxysporum f. sp. lini

Novel carbamic esters possessing a carbohydrate moiety derived from glycerol or D-glucose with two N,N-diethyldithiocarbamoyl groups and a series of bisdithiocarbamic esters having a ketone or an alkyl ester have been synthesized. The in vitro activity of these new compounds was evaluated against Fusarium oxysporum f. sp. lini. Some of the compounds [bis[1,3-S-(N,N-diethyldithiocarbamoyl)]-1,3-dideoxyglycerol) and diethyl N,N'-(1,3-dideoxyglycer-1,3-diyl)bis(dithiocarbamate)] were more active for inhibiting vegetative mycelium growth than, respectively, the commercial N,N-diethyldithiocarbamic acid sodium salt and Maneb. The structure activity of these new compounds is discussed.

Cytokine potentiator and pharmaceutical formulation for cytokine administration

A cytokine activity enhancer comprising an ethanolamine derivative of the following general formula (I) or a salt thereof, or comprising it along with cytokine or a cytokine production promoter; and also a medicine for diseases with lowered cytokine activity, comprising, as the active ingredient, the cytokine activity enhancer: STR1 wherein R1 is H, --CH3, --CH2 CH(CH3)OH or --CH2 CH2 OH; R2 is H, --CH3, --CH2 CH3 or --COOH; and R3 is H, --CH3, --CH2 CH3 or --CH2 NH2.