6283-81-4

Basic information

• Product Name: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER
• Synonyms: TIMTEC-BB SBB010886;ETHYL 3-OXO-3-(3-PYRIDYL)PROPIONATE;ETHYL-3-PYRIDOYL ACETATE;3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER;ethyl 3-oxo-3-pyridin-3-ylpropanoate(SALTDATA: FREE);Ethyl 3-oxo-3-(3-pyridinyl)propionate;3-keto-3-(3-pyridyl)propionic acid ethyl ester;3-oxo-3-(3-pyridyl)propanoic acid ethyl ester
• CAS NO: 6283-81-4
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Mol File: 6283-81-4.mol

Chemical Properties

• Boiling Point: 298 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER(6283-81-4)
• EPA Substance Registry System: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER(6283-81-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6283-81-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER is used as a key intermediate for the synthesis of a variety of drugs. Its ester functional group facilitates the formation of ester bonds in organic synthesis, which is crucial for creating new drug molecules with specific therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER is utilized as a building block for the development of new drugs that incorporate pyridine moieties. The presence of the pyridine ring in a drug molecule can impart unique pharmacological activities, making this compound an essential component in the design and synthesis of novel therapeutic agents.
Used in Organic Synthesis:
3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER is also used as a building block in the production of other organic compounds. Its ester functional group allows for various chemical reactions, enabling the synthesis of a wide range of organic molecules with diverse applications in different industries, including but not limited to pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C10H11NO3/c1-2-14-10(13)6-9(12)8-4-3-5-11-7-8/h3-5,7H,2,6H2,1H3

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 4013-72-3 nicotinoyl azide 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 59-67-6 nicotinic acid 
• 6148-64-7 ethyl potassium malonate 
• 59846-45-6 nicotinoyl imidazolide 
• 141-97-9 ethyl acetoacetate 
• 626-55-1 3-Bromopyridine 
• 15226-74-1 dicobalt octacarbonyl 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 37892-24-3 potassium diethyl malonate 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 94678-45-2 1,3,5-tris(3-pyridyl)pentane-1,5-dione 
• 54109-95-4 diethyl 3-pyridylcarbonylsuccinate 
• 350-03-8 methyl-3-pyridylketone 
• 6221-12-1 3-Bromoacetylpyridine 
• 109512-76-7 7-hydroxy-4-(pyridin-3-yl)coumarin 
• 86966-71-4 2,3-dihydro-6-hydroxy-3-oxo-2-phenyl-4-(β-pyridyl)-pyrazolo<3,4-b>pyridine 
• 89819-60-3 7-hydroxy-3-phenyl-5-(β-pyridyl)-pyrazolo<1,5-a>pyrimidine 
• 1026104-40-4 ethyl 3-(2-naphthylamino)-2-nicotinoyl-3-phenylpropanoate 
• 20856-18-2 1-(3-pyridyl)-3-phenylbenzoquinoline 
• 21683-61-4 3-(pyridin-3-yl)-1-phenyl-4,5-dihydropyrazol-5-one 
• 1404447-03-5 3-(4-fluorophenyl)-2-methyl-5-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1404447-04-6 3-(4-fluorophenyl)-5-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 136757-10-3 ethyl 3-amino-3-(pyridin-3-yl)acrylate 
• 1629162-14-6 (R)-benzyl 3-tert-butyl-4-oxo-1-(pyridin-3-yl)-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate 

Relevant articles and documents

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In order to solve the technical problems of complicated raw materials and flow, danger and low yield of a traditional 3-acetylpyridine synthesis method in the prior art, the invention provides a method for synthesizing 3-acetylpyridine by using a high-performance catalyst. The method comprises the concrete steps of carrying out transesterification: adopting niacin as a raw material, and carrying out transesterification on the niacin and ethyl acetate under the catalysis of the high-efficiency catalyst for transesterification, wherein the high-efficiency catalyst for transesterification is titanium dioxide and sodium ethoxide; carrying out condensation reaction: after completely carrying out transesterification, adding new ethyl acetate and a high-efficiency catalyst for condensation reaction so as to carry out condensation reaction, and obtaining a midbody I, wherein the high-efficiency catalyst for condensation reaction is sodium ethoxide or a mixture of the sodium ethoxide and titanium dioxide; hydrolyzing and refining: carrying out acid hydrolysis on the obtained midbody I so as to obtain a 3-acetylpyridine crude product, and refining to obtain a 3-acetylpyridine finished product. The synthesis method provided by the invention has the characteristics of short synthesis route, high yield, low cost, high product purity, simplicity in operation, suitability for large-scale industrial production and the like.

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