- Method for extracting 4-hydroxyisophthalic acid from waste slag for producing salicylic acid
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The invention discloses a method for extracting 4-hydroxyisophthalic acid from waste slag for producing salicylic acid, and belongs to the field of chemistry and chemical engineering. The waste slag for producing salicylic acid is used as raw materials; the steps of alkali dissolution, decoloring, acid separation and the like are performed to obtain a pure product of 4-hydroxyisophthalic acid. Thesteps in the operation process are simple; the use of complicated production equipment and process is avoided. Through the steps, the recovery and utilization of waste slag generated in the salicylicacid production process are realized.
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Paragraph 0025; 0026
(2018/06/15)
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- Method for extracting 4-hydroxy-m-phthalic acid from wintergreen oil production waste slag
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The invention discloses a method for extracting 4-hydroxy-m-phthalic acid from wintergreen oil production waste slag. The method comprises the following steps: 1. extraction of 4-hydroxy-dimethyl isophthalate crude product from wintergreen oil production waste slag: dissolving wintergreen oil production waste slag in an organic solvent, heating, filtering while the solution is hot, standing the filtrate to precipitate a solid, and drying the filter cake to obtain the 4-hydroxy-dimethyl isophthalate crude product; 2. hydrolysis of 4-hydroxy-dimethyl isophthalate crude product: adding the 4-hydroxy-dimethyl isophthalate crude product into an alkali solution, heating for hydrolysis, cooling to room temperature, adding a decolorant for decolorization, regulating the pH value of the filtrate to 1-4, precipitating a solid under acidic conditions, collecting the filter cake, and carrying out vacuum drying. By recycling the wintergreen oil production waste slag, the method enhances the resource utilization rate and lowers the 4-hydroxy-m-phthalic acid production cost. Besides, the method has the advantages of high yield, high purity, simple technique, mild conditions, no side reaction and the like.
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Paragraph 0026; 0027
(2017/01/17)
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- NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
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The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
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Paragraph 0141
(2014/03/25)
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- Inclusion complex containing epoxy resin composition for semiconductor encapsulation
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The invention is an epoxy resin composition for sealing a semiconductor, including (A) an epoxy resin and (B) a clathrate complex. The clathrate complex is one of (b1) an aromatic carboxylic acid compound, and (b2) at least one imidazole compound represented by formula (II): wherein R2 represents a hydrogen atom, C1-C10 alkyl group, phenyl group, benzyl group or cyanoethyl group, and R3 to R5 represent a hydrogen atom, nitro group, halogen atom, C1-C20 alkyl group, phenyl group, benzyl group, hydroxymethyl group or C1-C20 acyl group. The composition has improved storage stability, retains flowability when sealing, and achieves an effective curing rate applicable for sealing delicate semiconductors.
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- NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
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The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
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Page/Page column 44
(2012/10/23)
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- A recyclable nanoparticle-supported palladium catalyst for the hydroxycarbonylation of aryl halides in water
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Boomerang catalysis: A catalyst catchrelease system Is established by the noncovalent attachment of a Pd N-heterocyclic carbene complex to graphene-coated magnetic Co nanoparticles. The immobilization by pyrene tags (see scheme; blue) is reversible at elevated temperatures, releasing the homogeneous catalyst. The hydroxycarbonylation of aryl halides is performed in 16 iterative reactions with this highly active catalyst. (Figure Presented)
- Wittmann, Sebastian,Schaetz, Alexander,Grass, Robert N.,Stark, Wendelin J.,Reiser, Oliver
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supporting information; experimental part
p. 1867 - 1870
(2010/06/21)
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- Process for the synthesis of hydroxy aromatic acids
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Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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Page/Page column 21
(2008/06/13)
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- Regioselective Carboxylation of Phenols with Carbon Dioxide
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A few novel methods were developed for the regioselective preparation of p-hydroxybenzoic acid (pHBA) and its amino derivative by means of the Kolbe-Schmitt reaction. Thus, the carboxylation of tetraalkylammonium phenoxide at 125°C under the CO2 pressure of 5.0 MPa in the presence of K2CO3 gave pHBA in a maximum yield of 56% with the regioselectivity of 97-100%. The carboxylation of potassium phenoxide (PhOK) at 230°C under the CO2 pressure of 0.5 MPa also gave pHBA regioselectively in a 39% yield, together with unaltered phenol (61%) Under such conditions, the potassium salt of salicylic acid (SA) once formed was transformed into pHBA. Heat treatment of the dipotassium salt of 13C labeled SA indicated that the transformation occurs via two pathways, i.e., the intramolecular rearrangement of the salicylate (66%) and the decarboxylation of the salicylate followed by the recarboxylation of the resulting PhOK (34%). Furthermore, the carboxylation of cesium m-aminophenoxide and 5-amino-1-naphthoxide with CO2 gave regioselectively 4-hydroxyanthranilic and 8-amino-4-hydroxy-1-naphthoic acids, respectively, in good yields. This is a simple one-pot reaction giving these industrially useful acids with good yields.
- Rahim, Mohammad Abdur,Matsui, Yoshihisa,Matsuyama, Takanori,Kosugi, Yoshio
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p. 2191 - 2195
(2007/10/03)
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- Naaladase inhibitors for treating retinal disorders and glaucoma
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The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
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- Effects of alkali and alkaline earth metals on the Kolbe-Schmitt reaction
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It was found that the carboxylations of magnesium, calcium, and barium phenoxides with carbon dioxide at 260 °C produced salicylic acid and dicarboxylic acids (4-hydroxyisophthalic acid and 2-hydroxyisophthalic acid) in very high yields (80-100%), exceeding that of the ordinary Kolbe-Schmitt reaction. The orientation (ortho/para ratio) was controlled not only by chelations of the intermediate with alkaline earth metal (Mg, Ca, Ba) ions, resulting in salicylic acid, but also by the sizes of metal ions (Rb, Cs), giving p-hydroxybenzoic acid in a much higher ratio than the widely used method with potassium or sodium phenoxide. These alkaline earth metals worked to produce 3-hydroxy-2-naphthoic acid by the reaction of 2-naphthoxide with carbon dioxide, but the yield of 6-hydroxy-2-naphthoic acid was comparable to that of 3-hydroxy-2-naphthoic acid when cesium or rubidium 2 naphthoxide was employed. Considerably high yields (～60%) of 6-hydroxy-2-naphthoic acid, a monomer of one of the best liquid-crystal polymers, was attained by the carboxylation of cesium or rubidium 2-naphthoxide in the presence of potassium or sodium carbonate, where the alkali metal ion was supposed to increase the reactivity of the substrate. The formation of "binol" was observed in the preparation of 2-naphthoxides with metal hydroxides, especially with copper(II) ion.
- Rahim, Mohammad Abdur,Matsui, Yoshihisa,Kosugi, Yoshio
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p. 619 - 622
(2007/10/03)
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- Naaladase inhibitors for treating amyotrophic lateral sclerosis
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The present invention relates to pharmaceutical compositions and methods for treating amyotrophic lateral sclerosis using NAALADase inhibitors.
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- Benzenedicarboxylic acid derivatives
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New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neutopathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
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- Crystalline cepham acid addition salts and processes for their preparation
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Novel crystalline cephem acid addition salts and processes for their preparation Compounds of the formula I STR1 in which n is equal to 1 or 2 and m is 0.4-2.6, and where X is the anion of a carboxylic acid, have antibacterial activity.
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- Chemistry of furans: Part VII - Diels Alder reaction on substituted furanamides
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The scope of cycloaddition reaction of various dienophiles with 5-amino-2-furanamides has been studied.Acrylonitrile reacts with 5-piperidino-2-furanamides (4b-g) to yield the expected cycloaddition products (5).Several other dienophiles have been found to be unreactive.
- Rai, Usha Kumari,Shanker, Birja,Singh, Sujan,Rao, R. Balaji
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p. 870 - 871
(2007/10/02)
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- REDUCTION OF CARBON-CARBON DOUBLE BONDS AND HYDROGENOLYSIS BY SODIUM HYPOPHOSPHITE
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Sodium hypophosphite plus palladium-charcoal is a mild, economical, selective system for the reduction of carbon-carbon double bonds and hydrogenolysis of benzyl ethers and benzyl carbonates.
- Sala, Roberto,Doria, Gianfederico,Passarotti, Carlo
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p. 4565 - 4568
(2007/10/02)
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- Preparation of cyanophenols
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A process for the preparation of a cyanophenol of formula (I) SPC1 wherein Z is a substituent in the 4- or 6-position with respect to the hydroxy group, characterized in that cyanide ions are reacted in a dipolar aprotic solvent with a nitrobenzene of formula (II) SPC2 wherein Z has the same value as in formula (I) and is a group, other than a nitro group, known to withdraw electrons in substitution reactions and which does not contain a proton capable of ionizing under the defined reaction conditions if such ionization would inhibit the electron-withdrawing effect of the group Z. In formula (I) and (II) the benzene ring is optionally substituted by one or more non electron-withdrawing groups, or by one or more electron-withdrawing groups provided that such electron-withdrawing groups are in positions other than the 4- and 6-positions with respect to the hydroxy group. The compounds of formula (I) are of value in being readily hydrolysed to the corresponding salicylic acids of formula (III) SPC3 certain of which have been described in the literature as possessing a variety of pharmacological properties.
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