70291-67-7

Basic information

• Product Name: 4-(4-CHLOROPHENYL)MORPHOLINE
• Synonyms: 4-(4-CHLOROPHENYL)MORPHOLINE
• CAS NO: 70291-67-7
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66138
• EINECS: 200-110-4
• Product Categories: pharmacetical
• Mol File: 70291-67-7.mol

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 323.885°C at 760 mmHg
• Flash Point: 149.681°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.556
• Solubility: soluble in Toluene
• CAS DataBase Reference: 4-(4-CHLOROPHENYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-CHLOROPHENYL)MORPHOLINE(70291-67-7)
• EPA Substance Registry System: 4-(4-CHLOROPHENYL)MORPHOLINE(70291-67-7)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 70291-67-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-(4-CHLOROPHENYL)MORPHOLINE serves as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, facilitating the development of new drugs and pesticides to improve human and environmental health.
Used as a Corrosion Inhibitor:
In the materials protection industry, 4-(4-CHLOROPHENYL)MORPHOLINE functions as a corrosion inhibitor, helping to prevent the degradation of metals and extend the lifespan of industrial equipment and structures.
Used as a Reagent in Organic Synthesis:
4-(4-CHLOROPHENYL)MORPHOLINE acts as a reagent in organic synthesis, enabling the production of a wide range of chemical compounds for various applications.
Used as a Building Block in Chemical Production:
4-(4-CHLOROPHENYL)MORPHOLINE also operates as a building block in the creation of different chemical compounds, contributing to the advancement of chemical manufacturing processes.
Used in Pharmacological Research:
4-(4-CHLOROPHENYL)MORPHOLINE has been studied for its potential pharmacological properties, including its activity against certain diseases and biological targets, indicating its importance in the discovery and development of new therapeutic agents.
Overall, 4-(4-CHLOROPHENYL)MORPHOLINE is a versatile compound with significant roles in chemistry, pharmacology, and materials science, making it a valuable asset in the development of new products and technologies.

InChI:InChI=1/C10H12ClNO/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 106-46-7 para-dichlorobenzene 
• 106-47-8 4-chloro-aniline 
• 111-46-6 diethylene glycol 
• 698-69-1 4-chloro-N,N-dimethylaniline 
• 7460-82-4 diethylene glycol ditosylate 
• 106-39-8 bromochlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 110-89-4 piperidine 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 41605-52-1 4-chlorophenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 106-48-9 4-chloro-phenol 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 1070716-76-5 3-(1,3-benzodioxol-5-yl)-2-methyl-2-[4-(4-morpholinyl)phenyl]propanal 
• 10389-51-2 1-morpholino-4-nitrobenzene 
• 304675-41-0 N-(4-morpholinophenyl)-N'-phenylurea 
• 1316859-95-6 2-(4-morpholinobenzyl)aniline 
• 1316859-96-7 2-(4-morpholinobenzyl)phenol 
• 1316859-90-1 4-(4-(1-(2-nitrophenyl)-2-phenylethyl)phenyl)morpholine 
• 1316859-56-9 4-(4-(2-nitrobenzyl)phenyl)morpholine 
• 568577-88-8 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine 
• 6291-23-2 4-(4-morpholinyl)phenol 
• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 1451386-37-0 N-(4-morpholinophenyl)-8-pyrido[2,3-b]pyrazin-7-yl-[1,2,4]triazolo[1,5-a]pyrazin-2-amine 
• 1451386-40-5 [8-(3-fluoro-4-morpholin-4-ylmethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-(4-morpholin-4-yl-phenyl)amine 
• 92-53-5 4-Phenylmorpholine 
• 10282-31-2 4-morpholinobenzonitrile 

Relevant articles and documents

Effect of Precatalyst Oxidation State in C-N Cross-Couplings with 2-Phosphinoimidazole-Derived Bimetallic Pd(I) and Pd(II) Complexes

We report the catalytic activity of two phosphinoimidazole-derived bimetallic palladium complexes in Pd-catalyzed amination reactions. Our studies demonstrate that the starting oxidation state (Pd(I) or Pd(II)) of the dimeric complex has a significant effect on the efficiency of the catalytic reaction. The corresponding Pd(I) complex shows higher reactivity in Buchwald-Hartwig aminations, while the Pd(II) complex is much more reactive in carbonylative amination reactions. These new dimeric palladium complexes provide good to excellent reactivity and yields in the amination reactions tested.

N-heterocyclic carbene-Pd(II)-2-methyl-4,5-dihydrooxazole complex-catalyzed highly chemoselective mono-amination of dichlorobenzenes

The palladium-catalyzed chemoselective mono-amination of dichlorobenzenes was reported in this paper. Under the suitable conditions, all reactions involving the three isomers of dichlorobenzenes with various secondary and primary amines in the presence of

Photo-induced dealdehyding method

The invention provides a photo-induced dealdehyding method, and belongs to the technical field of organic synthesis. The photo-induced dealdehyding method comprises the following steps that a mixtureof a compound shown in the formula I and a solvent are reacted under an inert gas atmosphere and visible light irradiation, a dealdehyding product is obtained, and no photocatalyst is used in the whole process; wherein the structural formula of the formula I shown in the specification, R is a functional group and is selected from hydrogen, methyl, methoxyl, cyano, chlorine, bromine or fluorine. According to the photo-induced dealdehyding method, in the inert gas atmosphere, the compound shown in the formula (I) can be excited to generate carbon-oxygen bond homogeneous cracking through visiblelight irradiation, then free radical migration and double bond displacement are conducted, finally carbon monoxide is removed, aldehyde group removal is completed, no photocatalyst is needed in the whole process, operation is easy and convenient, and conditions are mild.

Copper-Catalyzed Electrophilic Amination of Alkoxyarylsilanes

We report a copper-catalyzed amination reaction between simple alkoxyarylsilanes and N-benzoyloxyamines. Silver fluoride serves as a stoichiometric base as well as an indispensable activator that allows the catalytic process to proceed. Multiply alkoxylated arylsilanes, such as trialkoxyarylsilanes and dialkoxyarylsilanes were transformed into the corresponding tertiary anilines under mild reaction conditions.

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

Buchwald-Hartwig amination using Pd(i) dimer precatalysts supported by biaryl phosphine ligands

We report the synthesis of air-stable Pd(i) dimer complexes featuring biaryl phosphine ligands. Catalytic experiments suggest that these complexes are competent precatalysts that can mediate cross-coupling amination reactions between aryl halides with bot

Copper-Mediated monochlorination of anilines and nitrogen-containing heterocycles

A simple and selective copper(II) chloride-mediated monochlorination of anilines and nitrogen-containing heterocycles has been developed. Stirring a mixture of aniline, copper(II) chloride, lithium chloride in EtOH under reflux condition produced 4-chloroaniline with high yield. Eighteen substrates including substituted anilines, N-substituted anilines, N,N-disubstituted anilines, 5-nitroindole and carbazole were all reactive and afforded desired products in moderate to excellent yields (52%–98%).

Three-Component Reactions of Arynes, Amines, and Nucleophiles via a One-Pot Process

An unprecedented three-component reaction of arynes, tertiary amines, and nucleophiles has been demonstrated through ammonium salt intermediates. This protocol allows access to tertiary aniline derivatives containing the piperazine motif in good-to-excell

Mechanism and Scope of Base-Controlled Catalyst-Free N-Arylation of Amines with Unactivated Fluorobenzenes

A general method for transition metal-free N-arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two-step synthesis of the antidepressant Vortioxetine.

ARYLATION OF ALIPHATIC AMINES

The invention relates to a method for arylation of amines, such as aliphatic amines by reaction of aryl-halogens, e.g. chloro- or fluorobenzene derivatives without strongly electron withdrawing substituents in the presence of a strong base.