78839-75-5

Basic information

• Product Name: N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE
• Synonyms: N-Boc 2-broMoaniline;tert-butyl (2-broMophenyl)carbaMate;2-Bromo-N-(tert-butoxycarbonyl) aniline;N-(tert-Butoxycarbonyl)-2-bromoaniline 97%;tert-Butyl (2-bromophenyl)
• CAS NO: 78839-75-5
• Molecular Formula: C₁₁H₁₄BrNO₂
• Molecular Weight: 272.14
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Protected Amines;amine|alkyl bromide| carboxylic ester
• Mol File: 78839-75-5.mol

Chemical Properties

• Boiling Point: 110 °C0.3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.342 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00408mmHg at 25°C
• Refractive Index: n20/D 1.54(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE(78839-75-5)
• EPA Substance Registry System: N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE(78839-75-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 78839-75-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE is used as a starting material for the synthesis of N-Boc-protected o-aryl anilines. The Boc group serves as a protecting agent for the aniline moiety, preventing unwanted reactions during the synthesis process.
Used in the Formation of Arene-Ynamides:
N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE undergoes coupling reactions with bromoacetylenes to form the corresponding arene-ynamides. These arene-ynamides are valuable intermediates in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds.

InChI:InChI=1/C11H14BrNO2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8(9)12/h4-7H,1-3H3,(H,13,14)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 615-36-1 2-bromoaniline 
• 50625-50-8 2-bromo-benzoyl azide 
• 75-65-0 tert-butyl alcohol 
• 3422-01-3 tert-butyl phenylcarbamate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 34619-03-9 tert-butyldicarbonate 
• 880384-47-4 di-tert-butyl (2-bromophenyl)carbamate 

Downstream Products

• 3422-01-3 tert-butyl phenylcarbamate 
• 78839-79-9 (4aS,9aR)-4a-Hydroxy-1,2,3,4,4a,9a-hexahydro-carbazole-9-carboxylic acid tert-butyl ester 
• 187099-49-6 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester 
• 159624-15-4 tert-butyl N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 
• 935742-36-2 (2-bromo-phenyl)-(2-methyl-allyl)-carbamic acid tert-butyl ester 
• 936641-28-0 cis-(2-styryl-phenyl)carbamic acid tert-butyl ester 
• 955123-21-4 [2-(1H-indol-5-yl)-phenyl]-carbamic acid tert-butyl ester 
• 936641-30-4 (Z)-2-(2-tert-butoxycarbonylamino-phenyl)-3-phenyl-acrylic acid 
• 51417-51-7 7-bromo-1H-indole 
• 70803-96-2 7-benzoylindole 
• 89976-15-8 7-iodo-1H-indole 
• 187099-50-9 (2-Bromo-6-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester 
• 187099-51-0 tert-butyl (2-iodo-6-((trimethylsilyl)ethynyl)phenyl)carbamate 
• 187099-52-1 [2-(3-Methyl-but-2-enyl)-6-trimethylsilanylethynyl-phenyl]-carbamic acid tert-butyl ester 

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