99586-65-9

Basic information

• Product Name: 4-Chloropyridine-2-carboxamide
• Synonyms: 4-Chloro-2-picolinamide;4-Chloropyridine-2-carboxamide ,95%;4-Chloropyridine-2-c;2-PyridinecarboxaMide,4-chloro;4-Chloropicolinamide, 2-Carbamoyl-4-chloropyridine;IFLAB-BB F2108-0034;4-CHLOROPICOLINAMIDE;4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID AMIDE
• CAS NO: 99586-65-9
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.57
• Product Categories: NULL;blocks;Carboxes;Pyridines;Pyridine series;Pyridine
• Mol File: 99586-65-9.mol

Chemical Properties

• Melting Point: 148-152
• Boiling Point: 298.1 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: Off-white/Solid
• Density: 1.381 g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.49±0.50(Predicted)
• CAS DataBase Reference: 4-Chloropyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-2-carboxamide(99586-65-9)
• EPA Substance Registry System: 4-Chloropyridine-2-carboxamide(99586-65-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 99586-65-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloropyridine-2-carboxamide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form diverse chemical structures, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-Chloropyridine-2-carboxamide is utilized as a precursor in the production of agrochemicals, specifically in the synthesis of pesticides and herbicides, due to its reactivity and potential to create effective active ingredients.
Used in Dye and Pigment Industry:
4-Chloropyridine-2-carboxamide is employed as a starting material in the synthesis of dyes and pigments, where its chemical properties allow for the creation of a variety of colorants used in different industries such as textiles, plastics, and printing inks.
Used in Research and Development:
4-Chloropyridine-2-carboxamide is used as a research chemical in academic and industrial laboratories, where it is studied and manipulated to understand its properties and explore its potential applications in various fields, including materials science and medicinal chemistry.

InChI:InChI=1/C6H5ClN2O/c7-4-1-2-9-5(3-4)6(8)10/h1-3H,(H2,8,10)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 7664-41-7 ammonia 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 1121-76-2 4-chloropyridine N-oxide 
• 176977-85-8 methyl 4-chloropyridine-2-carboxylate hydrochloride 
• 75-44-5 phosgene 
• 284462-78-8 4-(3-aminophenoxy)-N-methylpicolinamide 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 349-65-5 2-Methoxy-5-trifluoromethyl-aniline 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 
• 284462-80-2 4-(4-aminophenoxy)-2-pyridinecarboxamide 
• 150009-83-9 3-Amino-2-methoxyquinoline 

Downstream Products

• 19798-80-2 2-Amino-4-chloropyridine 
• 757251-54-0 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide 
• 928038-30-6 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide 
• 868736-13-4 4-(4-amino-2,5-difluorophenoxy)picolinamide 
• 868735-84-6 4-(4-amino-2,3-difluorophenoxy)picolinamide 
• 868735-85-7 4-(6-amino-2,3-diflurophenoxy)pyridine-2-carboxamide 
• 952490-94-7 4-(4-benzyloxy-phenoxy)-pyridine-2-carboxylic acid amide 
• 284462-79-9 4-(3-aminophenoxy)pyridine-2-carboxamide 
• 868733-71-5 4-(4-amino-2-fluorophenoxy)pyridin-2-carboxamide 
• 757251-55-1 4-(4-amino-2-chlorophenoxy)picolinamide 
• 284462-80-2 4-(4-aminophenoxy)-2-pyridinecarboxamide 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 930576-23-1 4-(2-carbamoylpyridin-4-yloxy)-3-fluorobenzoic acid 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 

Relevant articles and documents

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The invention discloses a preparation method of 2-cyano-4-fluoropyridine, which comprises the steps of by using 4-chloropyridine-2-methyl formate as a raw material, carrying out ester ammonolysis reaction, amide dehydration reaction and halogen exchange reaction to prepare the 2-cyano-4-fluoropyridine. The method is simple in synthesis process, mild in reaction condition, high in yield and good inproduct purity; the used raw materials are easy to obtain and low in cost, and the preparation method is suitable for industrial production.

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The invention discloses a preparation method of 2-amino-4-fluoropyridine, comprising the synthetic steps of 1, subjecting 2-pyridinecarboxylic acid as a raw material to reaction in the presence of thionyl chloride and a salt to obtain 4-chloropyridine-2-acyl chloride, and subjecting 4-chloropyridine-2-acyl chloride the presence of ammonia to obtain 4-chloropyridine-2-amide; 2, subjecting 4-chloropyridine-2-amide to Hofmann rearrangement reaction to obtain 2-amino-4-chloropyridine; 3, subjecting 2-amino-4-chloropyridine to halogen exchange to obtain 2-amino-4-fluoropyridine. The problems of theexisting preparation method, such as long synthetic path, operational complexity, high pollution of three wastes, poor atomic economy, low yield and high manufacture cost, are solved.

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