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10009-20-8

10009-20-8

Identification

Synonyms:L-Lysine,N6-(trifluoroacetyl)- (9CI);Lysine, N6-(trifluoroacetyl)-, L- (8CI);(S)-6-(Trifluoroacetylamino)-2-aminohexanoic acid;N6-(Trifluoroacetyl)-L-lysine;N6-(Trifluoroacetyl)lysine;Ne-Trifluoroacetyl-L-lysine;Nw-(Trifluoroacetyl)-L-lysine;H-Lys(Tfa)-OH;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:N6-Trifluoroacetyl-L-lysine
  • Packaging:2.5g
  • Price:$ 403
  • Delivery:In stock
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  • Manufacture/Brand:Usbiological
  • Product Description:Ne-Trifluoroacetyl-L-lysine
  • Packaging:10g
  • Price:$ 333
  • Delivery:In stock
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  • Manufacture/Brand:Usbiological
  • Product Description:Ne-Trifluoroacetyl-L-lysine
  • Packaging:5g
  • Price:$ 179
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:N6-Trifluoroacetyl-L-lysine
  • Packaging:25g
  • Price:$ 85
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Nε-Trifluoroacetyl-L-lysine >98.0%(T)
  • Packaging:5g
  • Price:$ 19
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Nε-Trifluoroacetyl-L-lysine >98.0%(T)
  • Packaging:25g
  • Price:$ 51
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:N-6-Trifluoroacetyl-L-lysine 98%
  • Packaging:1 g
  • Price:$ 15
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:N-6-Trifluoroacetyl-L-lysine 98%
  • Packaging:5 g
  • Price:$ 25
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:N-6-Trifluoroacetyl-L-lysine 98%
  • Packaging:25 g
  • Price:$ 60
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Nε-Trifluoroacetyl-L-lysine ≥96.0% (TLC)
  • Packaging:5 g
  • Price:$ 58.4
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Relevant articles and documentsAll total 4 Articles be found

N-trifluoroacyl lysine derivatives in the synthesis of L-lysyl-L-glutamic acid

Cherevin,Gulevich,Popova,Zubreichuk,Knizhnikov

, p. 1427 - 1431 (2007)

Conditions were developed for simultaneous preparation of N a-trifluoroacetyl-L-lysine and N α,N a-bis(trifluoroacetyl)-L-lysine at overall conversion of initial lysine monohydrochloride up to 82%. By reaction of dimethyl L-glutamate with N α,N a-bis(trifluoroacetyl)-L-lysyl chloride in the presence of triethylamine or with N α- carboxyanhydride of N a-trifluoroacetyl-L-lysine with subsequent removing protecting groups in the formed dipeptides by treating with water-ethanol solution of sodium hydroxide we obtained L-lysyl-L-glutamic acid. Physicochemical characteristics of samples obtained coincided with characteristics of L-lysyl-L-glutamic acid described in the literature thus suggesting that no racemization occurred either at the stage of peptide bond formation or at deprotection.

THERAPIES FOR CANCER USING ISOTOPICALLY SUBSTITUTED LYSINE

-

Page/Page column 7, (2009/10/22)

Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.

Process route upstream and downstream products

Process route

S-ethyl trifluoroacetate
383-64-2

S-ethyl trifluoroacetate

L-Lysine hydrochloride
657-27-2,10098-89-2,26124-78-7

L-Lysine hydrochloride

(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

Conditions
Conditions Yield
With sodium hydroxide;
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

L-Lysine hydrochloride
657-27-2,10098-89-2,26124-78-7

L-Lysine hydrochloride

(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

Conditions
Conditions Yield
With sodium; In ethanol; at 5 - 20 ℃;
62%
L-Lysine hydrochloride; With ethanol; sodium;
ethyl trifluoroacetate,; In ethanol; at 20 ℃; Cooling with ice;
With acetic acid; In ethanol;
62%
L-Lysine hydrochloride; With sodium; In ethanol; for 1h;
ethyl trifluoroacetate,; at 5 - 20 ℃; for 3h;
With acetic acid; for 0.166667h;
56%
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

sodium salt of L-lysine
16079-52-0

sodium salt of L-lysine

(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

N<sup>α</sup>,N<sup>ε</sup>-bis(trifluoroacetyl)-L-lysine
329-53-3

Nα,Nε-bis(trifluoroacetyl)-L-lysine

Conditions
Conditions Yield
In ethanol; at 5 - 20 ℃;
25%
56%
phosgene
75-44-5

phosgene

(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

N<sup>ε</sup>-trifluoroacetyl-L-lysine N<sup>α</sup>-carboxanhydride
42267-27-6

Nε-trifluoroacetyl-L-lysine Nα-carboxanhydride

Conditions
Conditions Yield
In tetrahydrofuran; at 20 - 30 ℃; for 4.33333h; Inert atmosphere;
86.5%
In 1,4-dioxane; at 45 ℃; for 2h;
70%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

N<sup>ε</sup>-trifluoroacetyl-L-lysine N<sup>α</sup>-carboxanhydride
42267-27-6

Nε-trifluoroacetyl-L-lysine Nα-carboxanhydride

Conditions
Conditions Yield
With sodium hydroxide; In tetrahydrofuran; at 50 ℃; Inert atmosphere;
75%
With Pinene; In ethyl acetate; at 105 - 110 ℃;
(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

N<sup>ε</sup>-trifluoroacetyl-L-lysine N<sup>α</sup>-carboxanhydride
42267-27-6

Nε-trifluoroacetyl-L-lysine Nα-carboxanhydride

Conditions
Conditions Yield
In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;
75%
With sodium hydroxide; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;
75%
In ethyl acetate; at 70 ℃; for 4h;
63%
phosgene
75-44-5

phosgene

(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

N<sup>ε</sup>-trifluoroacetyl-L-lysine N<sup>α</sup>-carboxanhydride
42267-27-6

Nε-trifluoroacetyl-L-lysine Nα-carboxanhydride

C<sub>9</sub>H<sub>11</sub>Cl<sub>2</sub>F<sub>3</sub>N<sub>2</sub>O<sub>3</sub>
112139-30-7

C9H11Cl2F3N2O3

Conditions
Conditions Yield
In tetrahydrofuran; N,N-dimethyl-formamide; at 30 ℃; for 2.5h; Title compound not separated from byproducts;
(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

N<sup>ε</sup>-trifluoroacetyl-L-lysine N<sup>α</sup>-carboxanhydride
42267-27-6

Nε-trifluoroacetyl-L-lysine Nα-carboxanhydride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 2.5 h / 30 °C
2: 88 percent / tetrahydrofuran / 4 h / 25 °C
In tetrahydrofuran;
(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

N-phenyl-1H-benzo[d][1,2,3]triazole-1-carboxamide
86298-24-0

N-phenyl-1H-benzo[d][1,2,3]triazole-1-carboxamide

C<sub>15</sub>H<sub>18</sub>F<sub>3</sub>N<sub>3</sub>O<sub>4</sub>

C15H18F3N3O4

Conditions
Conditions Yield
With triethylamine; In water; acetonitrile; at 20 ℃; for 0.5h; chemoselective reaction;
92%
(S)-6-trifluoroacetylamino-2-aminohexanoic acid
10009-20-8,96193-68-9

(S)-6-trifluoroacetylamino-2-aminohexanoic acid

ethyl (E)-4-oxo-4-phenyl-2-butenoate
15121-89-8

ethyl (E)-4-oxo-4-phenyl-2-butenoate

N<sub>2</sub>-(1-ethoxycarbonyl-3-phenyl-propyl)-N<sub>6</sub>-trifluoroacetyl-L-lysine

N2-(1-ethoxycarbonyl-3-phenyl-propyl)-N6-trifluoroacetyl-L-lysine

Conditions
Conditions Yield
(S)-6-trifluoroacetylamino-2-aminohexanoic acid; ethyl (E)-4-oxo-4-phenyl-2-butenoate; With lithium hydroxide; In ethanol; water; at -5 ℃; for 0.5h;
With palladium 10% on activated carbon; In ethanol; at 40 ℃;

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