101251-09-6Relevant articles and documents
Susceptibility to hydrolysis of phenylboronic pinacol esters at physiological pH
Achilli, Cesare,Ciana, Annarita,Fagnoni, Maurizio,Balduini, Cesare,Minetti, Giampaolo
, p. 137 - 139 (2013)
Boronic acids and their esters are highly considered compounds for the design of new drugs and drug delivery devices, particularly as boron-carriers suitable for neutron capture therapy. However, these compounds are only marginally stable in water. Hydrol
A method of preparing 4-aminophenylboronic acid derivatives
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Paragraph 0017; 0018; 0020, (2017/09/01)
The invention belongs to the technical field of medicine intermediates, and particularly relates to a method of preparing 4-aminophenylboronic acid derivatives. According to the method, 4-nitrophenylboronic acid is adopted as a raw material and subjected
Synthesis and biological activity of new 4-(Pyridin-4-yl)-(3-methoxy-5- methylphenyl)- 1H-pyrazoles derivatives as ROS Receptor tyrosine kinase inhibitors
Park, Byung Sun,El-deeb, Ibrahim M.,Yoo, Kyung Ho,Han, Dong Keun,Tae, Jin Sung,Lee, So Ha
, p. 3629 - 3634 (2013/01/16)
A series of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles (6a-k & 7a-l) has been rationally designed based on the structure of the lead compound KIST301080, a selective ROS receptor tyrosine kinase inhibitor, in order to study the activity of ROS of this new class of inhibitors. The compounds were synthesized and screened against ROS kinase, where compound 6h showed moderate inhibitory activity with an IC50 value of 6.25 μM. The study emphasized the importance of the acetonitrile group at the pyrazole ring and also the importance of having a hydrogen bond donor on the distal phenyl ring linked to the pyridine moiety.